age: 9.1 gender: female location: cortex, right frontal diagnosis: pnet pre-treatment: radiation and chemotherapy source: recurrent, surgery stage: m0 treatment_follow_up: efs_(months): 14.9 from diagnosis os_(months): 24.4 from diagnosis consent:
pathology_of_human_tumor:at original diagnosis: high grade neoplastic population of cells. these have small, moderately pleomorphic round to oval and often angulated dark blue nuclei with small blue nucleoli. the cells have a small amount of pink cytoplasm. there is a background of pink neuropil, and in areas the nuclei palisade in a striped pattern along the pink neuropil. there are individual apoptotic cells as well as field necrosis, and mitoses are plentiful. the neoplastic cells infiltrate adjacent brain tissue. at recurrence: predominant features of a glioblastoma multiforme with pseudo-palisading necrosis, vascular proliferation and immunoreactivity for gfap supporting glial astrocytic differentiation.
mouse_strain: cell line site_of_transplantation: - protocol: olson lab tissue culture protocol days_to_p0_p1_p2: - pi: james m. olson contact: http://www.btrl.org/product/pnet-109fhtc/
entity: high-grade glioma subgroup: mycn curated_lesions: mycn (amplification), id2 (amplification), egfr (amplification), (no mutation data for cell line)