Go to: Main R2: R2 Citations in PubMed
Online Tutorial
Publications that made use of/cited the R2 platform

R210.8177 citations
Explore the R2 Author Network

2021 (n=300)
1805Mugoni V et.al. (2021). Circulating RNAs in prostate cancer patients. Cancer Lett :.
1804Kim J et.al. (2021). Single-cell RNA sequencing for the identification of early-stage lung cancer biomarkers from circulating blood. NPJ Genom Med 6:87.
1803Schmidt O et.al. (2021). Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis. J Exp Clin Cancer Res 40:322.
1802Li W et.al. (2021). TRIP4 transcriptionally activates DDIT4 and subsequent mTOR signaling to promote glioma progression. Free Radic Biol Med :.
1801Chuang HY et.al. (2021). The E3 Ubiquitin Ligase NEDD4-1 Mediates Temozolomide-Resistant Glioblastoma through PTEN Attenuation and Redox Imbalance in Nrf2-HO-1 Axis. Int J Mol Sci 22:.
1800Jimenez C et.al. (2021). Neuronal Differentiation-Related Epigenetic Regulator ZRF1 Has Independent Prognostic Value in Neuroblastoma but Is Functionally Dispensable In Vitro. Cancers (Basel) 13:.
1799De Wyn J et.al. (2021). MEIS2 Is an Adrenergic Core Regulatory Transcription Factor Involved in Early Initiation of TH-MYCN-Driven Neuroblastoma Formation. Cancers (Basel) 13:.
1798Allen TA et.al. (2021). A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation. Front Oncol 11:641187.
1797Zhan F et.al. (2021). RhoA enhances osteosarcoma resistance to MPPa-PDT via the Hippo/YAP signaling pathway. Cell Biosci 11:179.
1796Anantha J et.al. (2021). NME1 Protects Against Neurotoxin-, alpha-Synuclein Mol Neurobiol :.
1795Khan MT et.al. (2021). Identification of Gender-Specific Molecular Differences in Glioblastoma (GBM) and Low-Grade Glioma (LGG) by the Analysis of Large Transcriptomic and Epigenomic Datasets. Front Oncol 11:699594.
1794Daub JT et.al. (2021). A systematic analysis of genetic interactions and their underlying biology in childhood cancer. Commun Biol 4:1139.
1793Prieto-Garcia C et.al. (2021). Inhibition of USP28 overcomes Cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway. Cell Death Differ :.
1792Tu R et.al. (2021). USP29 coordinates MYC and HIF1alpha stabilization to promote tumor metabolism and progression. Oncogene :.
1791van der Meer JHM et.al. (2021). Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis. Cell Death Dis 12:897.
1790Kinoshita H et.al. (2021). The Thioredoxin Reductase Inhibitor Auranofin Suppresses Pulmonary Metastasis of Osteosarcoma, But Not Local Progression. Anticancer Res 41:4947-4955.
1789Kisling SG et.al. (2021). Implications of prognosis-associated genes in pancreatic tumor metastasis: lessons from global studies in bioinformatics. Cancer Metastasis Rev :.
1788Karachaliou N et.al. (2021). BRCA1 Expression and Outcome in Patients With EGFR-Mutant NSCLC Treated With Gefitinib Alone or in Combination With Olaparib. JTO Clin Res Rep 2:100113.
1787Hupfer A et.al. (2021). Matrix stiffness drives stromal autophagy and promotes formation of a protumorigenic niche. Proc Natl Acad Sci U S A 118:.
1786Veronez LC et.al. (2021). MSI2 expression in adrenocortical carcinoma: Association with unfavorable prognosis and correlation with steroid and immune-related pathways. J Cell Biochem :.
1785Maklad A et.al. (2021). Calcium Signalling in Medulloblastoma: An In Silico Analysis of the Expression of Calcium Regulating Genes in Patient Samples. Genes (Basel) 12:.
1784Bamodu OA et.al. (2021). Concomitant High Apoptosis Inhibitor of Macrophage (AIM) and Low Prostate-Specific Antigen (PSA) Indicates Activated T Cell-Mediated Anticancer Immunity, Enhance Sensitivity to Pembrolizumab, and Elicit Good Prognosis in Prostate Cancer. Biomedicines 9:.
1783Lavaud M et.al. (2021). Overexpression of the Ubiquitin Specific Proteases USP43, USP41, USP27x and USP6 in Osteosarcoma Cell Lines: Inhibition of Osteosarcoma Tumor Growth and Lung Metastasis Development by the USP Antagonist PR619. Cells 10:.
1782Spek CA et.al. (2021). CEBPD Potentiates the Macrophage Inflammatory Response but CEBPD Knock-Out Macrophages Fail to Identify CEBPD-Dependent Pro-Inflammatory Transcriptional Programs. Cells 10:.
1781Spirin P et.al. (2021). Cytotoxic Marine Alkaloid 3,10-Dibromofascaplysin Induces Apoptosis and Synergizes with Cytarabine Resulting in Leukemia Cell Death. Mar Drugs 19:.
1780Gkikas D et.al. (2021). Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignancies. Proc Natl Acad Sci U S A 118:.
1779Lebedev T et.al. (2021). Growth factor signaling predicts therapy resistance mechanisms and defines neuroblastoma subtypes. Oncogene :.
1778Li X et.al. (2021). ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction. Cell Rep 36:109706.
1777Wang J et.al. (2021). Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity. PLoS Biol 19:e3001394.
1776Magne N et.al. (2021). PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth. Cell Oncol (Dordr) :.
1775Kim JH et.al. (2021). SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity. Nat Commun 12:5551.
1774Deng MY et.al. (2021). Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B. Nat Commun 12:5530.
1773Xu YQ et.al. (2021). A Novel Microfluidic Chip for Fast, Sensitive Quantification of Plasma Extracellular Vesicles as Biomarkers in Patients With Osteosarcoma. Front Oncol 11:709255.
1772Park SY et.al. (2021). Aberrant activation of the CD45-Wnt signaling axis promotes stemness and therapy resistance in colorectal cancer cells. Theranostics 11:8755-8770.
1771Di Giulio S et.al. (2021). A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors. Oncogene :.
1770Muller M et.al. (2021). Combining APR-246 and HDAC-Inhibitors: A Novel Targeted Treatment Option for Neuroblastoma. Cancers (Basel) 13:.
1769Langenberg KPS et.al. (2021). The Landscape of Pediatric Precision Oncology: Program Design, Actionable Alterations, and Clinical Trial Development. Cancers (Basel) 13:.
1768Martinez-Sanz P et.al. (2021). CD47-SIRPalpha Checkpoint Inhibition Enhances Neutrophil-Mediated Killing of Dinutuximab-Opsonized Neuroblastoma Cells. Cancers (Basel) 13:.
1767Roig-Carles D et.al. (2021). The Long Non-Coding RNA H19 Drives the Proliferation of Diffuse Intrinsic Pontine Glioma with H3K27 Mutation. Int J Mol Sci 22:.
1766Bedoya-Reina OC et.al. (2021). Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors. Nat Commun 12:5309.
1765Moriconi C et.al. (2021). Caveolin-1, a Key Mediator Across Multiple Pathways in Glioblastoma and an Independent Negative Biomarker of Patient Survival. Front Oncol 11:701933.
1764Belpaire M et.al. (2021). HOXA1 Is an Antagonist of ERalpha in Breast Cancer. Front Oncol 11:609521.
1763Feng H et.al. (2021). FOXK2 transcriptionally activating VEGFA induces apatinib resistance in anaplastic thyroid cancer through VEGFA/VEGFR1 pathway. Oncogene :.
1762Zhang Y et.al. (2021). Hypermethylation and Downregulation of UTP6 Are Associated With Stemness Properties, Chemoradiotherapy Resistance, and Prognosis in Rectal Cancer: A Co-expression Network Analysis. Front Cell Dev Biol 9:607782.
1761van den Boogaard ML et.al. (2021). Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma. Proc Natl Acad Sci U S A 118:.
1760Peng G et.al. (2021). LINC00152 acts as a potential marker in gliomas and promotes tumor proliferation and invasion through the LINC00152/miR-107/RAB10 axis. J Neurooncol :.
1759Pan LJ et.al. (2021). Exportin-T: A Novel Prognostic Predictor and Potential Therapeutic Target for Neuroblastoma. Technol Cancer Res Treat 20:15330338211039132.
1758Yu Y et.al. (2021). Therapeutic targeting of both dihydroorotate dehydrogenase and nucleoside transport in MYCN-amplified neuroblastoma. Cell Death Dis 12:821.
1757Truong DQ et.al. (2021). Collagen XI Alpha 1 (COL11A1) Expression in the Tumor Microenvironment Drives Neuroblastoma Dissemination. Pediatr Dev Pathol :10935266211039200.
1756Vivarelli S et.al. (2021). YY1 Silencing Induces 5-Fluorouracil-Resistance and BCL2L15 Downregulation in Colorectal Cancer Cells: Diagnostic and Prognostic Relevance. Int J Mol Sci 22:.
1755Aykul S et.al. (2021). Smad2/3 Activation Regulates Smad1/5/8 Signaling via a Negative Feedback Loop to Inhibit 3T3-L1 Adipogenesis. Int J Mol Sci 22:.
1754Seok J et.al. (2021). Multi-Omics Analysis of SOX4, SOX11, and SOX12 Expression and the Associated Pathways in Human Cancers. J Pers Med 11:.
1753Duitman J et.al. (2021). Non-Tumor CCAAT/Enhancer-Binding Protein Delta Potentiates Tumor Cell Extravasation and Pancreatic Cancer Metastasis Formation. Biomolecules 11:.
1752Paumann-Page M et.al. (2021). Peroxidasin protein expression and enzymatic activity in metastatic melanoma cell lines are associated with invasive potential. Redox Biol 46:102090.
1751Romiani A et.al. (2021). Neuroblastoma xenograft models demonstrate the therapeutic potential of (177)Lu-octreotate. BMC Cancer 21:950.
1750Sales-Gil R et.al. (2021). Non-redundant functions of H2A.Z.1 and H2A.Z.2 in chromosome segregation and cell cycle progression. EMBO Rep :e52061.
1749Alhalabi KT et.al. (2021). PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum. Acta Neuropathol :.
1748Jin TY et.al. (2021). LEP as a potential biomarker in prognosis of breast cancer: Systemic review and meta analyses (PRISMA). Medicine (Baltimore) 100:e26896.
1747Di Franco S et.al. (2021). Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery. Nat Commun 12:5006.
1746Shi M et.al. (2021). HMGA1 promotes hepatocellular carcinoma proliferation, migration, and regulates cell cycle via miR-195-5p. Anticancer Drugs :.
1745Smit WL et.al. (2021). Translation initiation factor eIF2Bepsilon promotes Wnt-mediated clonogenicity and global translation in intestinal epithelial cells. Stem Cell Res 55:102499.
1744Gong C et.al. (2021). Over-expression of vitronectin correlates with impaired survival in gastric cancers. Medicine (Baltimore) 100:e26766.
1743Li M et.al. (2021). Fat1 suppresses the tumor-initiating ability of nonsmall cell lung cancer cells by promoting Yes-associated protein 1 nuclear-cytoplasmic translocation. Environ Toxicol :.
1742Mori Y et.al. (2021). Deep learning-based gene selection in comprehensive gene analysis in pancreatic cancer. Sci Rep 11:16521.
1741Yang G et.al. (2021). NDRG1 enhances the sensitivity of cetuximab by modulating EGFR trafficking in colorectal cancer. Oncogene :.
1740Yang T et.al. (2021). Decoding DNA methylation in epigenetics of multiple myeloma. Blood Rev :100872.
1739Shen A et.al. (2021). Targeting NUFIP1 Suppresses Growth and Induces Senescence of Colorectal Cancer Cells. Front Oncol 11:681425.
1738Poli E et.al. (2021). Autoantibody profiling of alveolar rhabdomyosarcoma patients unveils tumor-associated antigens with diagnostic and prognostic significance. Oncoimmunology 10:1954765.
1737Jimenez-Garcia MP et.al. (2021). Empty spiracles homeobox genes EMX1 and EMX2 regulate WNT pathway activation in sarcomagenesis. J Exp Clin Cancer Res 40:247.
1736Meyer S et.al. (2021). Distinct Molecular Mechanisms of Altered HLA Class II Expression in Malignant Melanoma. Cancers (Basel) 13:.
1735Rea J et.al. (2021). Identification and Functional Characterization of Novel MYC-Regulated Long Noncoding RNAs in Group 3 Medulloblastoma. Cancers (Basel) 13:.
1734Bai X et.al. (2021). Kruppel-like factor 9 upregulates E-cadherin transcription and represses breast cancer invasion and metastasis. Am J Cancer Res 11:3660-3673.
1733Subramanian C et.al. (2021). Identification of novel lipid metabolic biomarkers associated with poor adrenocortical carcinoma prognosis using integrated bioinformatics. Surgery :.
1732Li M et.al. (2021). TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and proliferation of osteosarcoma by promoting KANK1 degradation. Cell Death Dis 12:767.
1731Xiong F et.al. (2021). Plastin-3 is a diagnostic and prognostic marker for pancreatic adenocarcinoma and distinguishes from diffuse large B-cell lymphoma. Cancer Cell Int 21:411.
1730Raman S et.al. (2021). A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope. Cell Rep Med 2:100344.
1729Suresh R et.al. (2021). Expression of cell type incongruent alpha-cardiac actin 1 subunit in medulloblastoma reveals a novel mechanism for cancer cell survival and control of migration. Neurooncol Adv 3:vdab064.
1728Feng C et.al. (2021). A Deep-Learning Model With the Attention Mechanism Could Rigorously Predict Survivals in Neuroblastoma. Front Oncol 11:653863.
1727Medeiros M et.al. (2021). The multifaceted NF-kB: are there still prospects of its inhibition for clinical intervention in pediatric central nervous system tumors? Cell Mol Life Sci :.
1726Rugolo F et.al. (2021). The expression of ELOVL4, repressed by MYCN, defines neuroblastoma patients with good outcome. Oncogene :.
1725Nowak JK et.al. (2021). Expression profiling of ileal mucosa in asthma reveals upregulation of innate immunity and genes characteristic of Paneth and goblet cells. Allergy Asthma Clin Immunol 17:82.
1724Adolphe C et.al. (2021). SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation. Mol Cancer Res :.
1723Heisey DAR et.al. (2021). Pharmaceutical interference of the EWS-FLI1-driven transcriptome by co-targeting H3K27ac and RNA polymerase activity in Ewing Sarcoma. Mol Cancer Ther :.
1722Chao CH et.al. (2021). Mutant p53 Attenuates Oxidative Phosphorylation and Facilitates Cancer Stemness through Downregulating miR-200c-PCK2 Axis in Basal-Like Breast Cancer. Mol Cancer Res :.
1721Miyamoto R et.al. (2021). HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways. Elife 10:.
1720Nazio F et.al. (2021). Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling. Acta Neuropathol :.
1719Klonou A et.al. (2021). Histone Mark Profiling in Pediatric Astrocytomas Reveals Prognostic Significance of H3K9 Trimethylation and Histone Methyltransferase SUV39H1. Neurotherapeutics :.
1718Mulvey B et.al. (2021). Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays. Transl Psychiatry 11:403.
1717Lak NSM et.al. (2021). Improving risk stratification for pediatric patients with rhabdomyosarcoma by molecular detection of disseminated disease. Clin Cancer Res :.
1716Slapak EJ et.al. (2021). ADAM9-Responsive Mesoporous Silica Nanoparticles for Targeted Drug Delivery in Pancreatic Cancer. Cancers (Basel) 13:.
1715Shi D et.al. (2021). Development of a Novel Immune Infiltration-Related ceRNA Network and Prognostic Model for Sarcoma. Front Cell Dev Biol 9:652300.
1714Uckun E et.al. (2021). BioID-Screening Identifies PEAK1 and SHP2 as Components of the ALK Proximitome in Neuroblastoma Cells. J Mol Biol 433:167158.
1713van Duijn A et.al. (2021). A secondary role for hypoxia and HIF1 in the regulation of (IFNgamma-induced) PD-L1 expression in melanoma. Cancer Immunol Immunother :.
1712Yankaskas CL et.al. (2021). The fluid shear stress sensor TRPM7 regulates tumor cell intravasation. Sci Adv 7:.
1711Anderson NM et.al. (2021). Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma. Cancer Res :.
1710Gu Y et.al. (2021). MCM6 indicates adverse tumor features and poor outcomes and promotes G1/S cell cycle progression in neuroblastoma. BMC Cancer 21:784.
1709Eleveld TF et.al. (2021). Engineering large-scale chromosomal deletions by CRISPR-Cas9. Nucleic Acids Res :.
1708Villasante A et.al. (2021). Horizontal transfer of the stemness-related markers EZH2 and GLI1 by neuroblastoma-derived extracellular vesicles in stromal cells. Transl Res :.
1707Wang Q et.al. (2021). DNMT1-mediated methylation of BEX1 regulates stemness and tumorigenicity in liver cancer. J Hepatol :.
1706Dang TT et.al. (2021). Loss of CENP-I Impairs Homologous Recombination and Sensitizes Cells to PARP1 Inhibition. Cancers (Basel) 13:.
1705Uva P et.al. (2021). Connectivity Map Analysis Indicates PI3K/Akt/mTOR Inhibitors as Potential Anti-Hypoxia Drugs in Neuroblastoma. Cancers (Basel) 13:.
1704Martirosian V et.al. (2021). Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Rep 35:109302.
1703Novita Sari I et.al. (2021). Metabolism and function of polyamines in cancer progression. Cancer Lett :.
1702Frenkel N et.al. (2021). Long-Lived Human Lymphatic Endothelial Cells to Study Lymphatic Biology and Lymphatic Vessel/Tumor Coculture in a 3D Microfluidic Model. ACS Biomater Sci Eng :.
1701Burgess D et.al. (2021). A comprehensive view of human RNAs. Nat Rev Genet :.
1700Moreno-Smith M et.al. (2021). Restoration of the molecular clock is tumor suppressive in neuroblastoma. Nat Commun 12:4006.
1699Burns JE et.al. (2021). The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets. Cancer Sci :.
1698Kapoor A et.al. (2021). MUCIN 1 in Prostate Cancer :.
1697Chen Q et.al. (2021). ADHFE1 is a correlative factor of patient survival in cancer. Open Life Sci 16:571-582.
1696Nie K et.al. (2021). SNAT2/SLC38A2 Confers the Stemness of Gastric Cancer Cells via Regulating Glutamine Level. Dig Dis Sci :.
1695Ivanova E et.al. (2021). DYRK3 contributes to differentiation and hypoxic control in neuroblastoma. Biochem Biophys Res Commun 567:215-221.
1694Willemsen M et.al. (2021). Immunophenotypic analysis reveals differences in circulating immune cells in peripheral blood of segmental and non-segmental vitiligo patients. J Invest Dermatol :.
1693Ballabio C et.al. (2021). Notch1 switches progenitor competence in inducing medulloblastoma. Sci Adv 7:.
1692Tang Y et.al. (2021). Upregulation of HOXC9 generates interferon-gamma resistance in gastric cancer by inhibiting the DAPK1/RIG1/STAT1 axis. Cancer Sci 112:3455-3468.
1691Genovesi LA et.al. (2021). Systems pharmacogenomics identifies novel targets and clinically actionable therapeutics for medulloblastoma. Genome Med 13:103.
1690Laine A et.al. (2021). CIP2A interacts with TopBP1 and drives basal-like breast cancer tumorigenesis. Cancer Res :.
1689Luu K et.al. (2021). B7-H7 Is Inducible on T Cells to Regulate Their Immune Response and Serves as a Marker for Exhaustion. Front Immunol 12:682627.
1688Lorenzi L et.al. (2021). The RNA Atlas expands the catalog of human non-coding RNAs. Nat Biotechnol :.
1687Li M et.al. (2021). ISL1 promoted tumorigenesis and EMT via Aurora kinase A-induced activation of PI3K/AKT signaling pathway in neuroblastoma. Cell Death Dis 12:620.
1686Minderman M et.al. (2021). Immune evasion in primary testicular and central nervous system lymphomas: HLA loss rather than 9p24.1/PD-L1/PD-L2 alterations. Blood 138:1194-1197.
1685Wang WH et.al. (2021). Proteomic Analysis Reveals That Metformin Suppresses PSMD2, STIP1, and CAP1 for Preventing Gastric Cancer AGS Cell Proliferation and Migration. ACS Omega 6:14208-14219.
1684Mazzocchi M et.al. (2021). LMK235, a small molecule inhibitor of HDAC4/5, protects dopaminergic neurons against neurotoxin Mol Cell Neurosci :103642.
1683Clemente-Olivo MP et.al. (2021). Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression marks human obesity. Metabolism :154815.
1682Radke K et.al. (2021). Anti-tumor effects of rigosertib in high-risk neuroblastoma. Transl Oncol 14:101149.
1681Kimura H et.al. (2021). The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers. Oncogene :.
1680Mazor G et.al. (2021). TP73-AS1 is induced by YY1 during TMZ treatment and highly expressed in the aging brain. Aging (Albany NY) 13:.
1679Schmitt-Hoffner F et.al. (2021). FOXR2 Stabilizes MYCN Protein and Identifies Non-MYCN-Amplified Neuroblastoma Patients With Unfavorable Outcome. J Clin Oncol :JCO2002540.
1678Vassal G et.al. (2021). International consensus on minimum preclinical testing requirements for the development of innovative therapies for children and adolescents with cancer. Mol Cancer Ther :.
1677Tirado-Gonzalez I et.al. (2021). AXL inhibition in macrophages stimulates host-versus-leukemia immunity and eradicates naive and treatment resistant leukemia. Cancer Discov :.
1676Garcia TM et.al. (2021). Early life antibiotics influence in vivo and in vitro mouse intestinal epithelium maturation and functioning. Cell Mol Gastroenterol Hepatol :.
1675Ni H et.al. (2021). MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis. Stem Cell Res Ther 12:325.
1674van Neerven SM et.al. (2021). Apc-mutant cells act as supercompetitors in intestinal tumour initiation. Nature :.
1673Vriend J et.al. (2021). Ubiquitin Proteasome Pathway Transcriptome in Epithelial Ovarian Cancer. Cancers (Basel) 13:.
1672Pelosi A et.al. (2021). Pediatric Tumors-Mediated Inhibitory Effect on NK Cells: The Case of Neuroblastoma and Wilms Tumors. Cancers (Basel) 13:.
1671Fairchild CK Jr et.al. (2021). Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA. Cancers (Basel) 13:.
1670Cantalupo S et.al. (2021). Regulatory Noncoding and Predicted Pathogenic Coding Variants of CCR5 Predispose to Severe COVID-19. Int J Mol Sci 22:.
1669Bley N et.al. (2021). Musashi-1-A Stemness RBP for Cancer Therapy? Biology (Basel) 10:.
1668Mehibel M et.al. (2021). Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models. J Clin Invest 131:.
1667Tu Z et.al. (2021). The LINC01119-SOCS5 axis as a critical theranostic in triple-negative breast cancer. NPJ Breast Cancer 7:69.
1666Zhuang Q et.al. (2021). Prognostic and immunological roles of Fc fragment of IgG binding protein in colorectal cancer. Oncol Lett 22:526.
1665Tabassum A et.al. (2021). Transporter associated with antigen processing 1 (TAP1) expression and prognostic analysis in breast, lung, liver, and ovarian cancer. J Mol Med (Berl) :.
1664Lotsch D et.al. (2021). Targeting fibroblast growth factor receptors to combat aggressive ependymoma. Acta Neuropathol :.
1663Sacchetti A et.al. (2021). Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer. Elife 10:.
1662Zong B et.al. (2021). HORMAD1 promotes docetaxel resistance in triple negative breast cancer by enhancing DNA damage tolerance. Oncol Rep 46:.
1661Misiak D et.al. (2021). The MicroRNA Landscape of MYCN-Amplified Neuroblastoma. Front Oncol 11:647737.
1660Tan X et.al. (2021). Downregulation of fibronectin 1 attenuates ATRA-induced inhibition of cell migration and invasion in neuroblastoma cells. Mol Cell Biochem :.
1659Gutierrez LM et.al. (2021). Up-regulation of pro-angiogenic molecules and events does not relate with an angiogenic switch in metastatic osteosarcoma cells but to cell survival features. Apoptosis :.
1658Seier JA et.al. (2021). Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma. J Immunother Cancer 9:.
1657Sun L et.al. (2021). eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway. J Transl Med 19:216.
1656Susmi TF et.al. (2021). Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer. BMC Cancer 21:577.
1655Lu Y et.al. (2021). MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma. Cell Death Dis 12:511.
1654Bae WY et.al. (2021). beta-arrestin 2 stimulates degradation of HIF-1alpha and modulates tumor progression of glioblastoma. Cell Death Differ :.
1653Prokakis E et.al. (2021). USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response. Oncogene :.
1652Schanzer A et.al. (2021). Mutations in HID1 cause syndromic infantile encephalopathy and hypopituitarism. Ann Neurol :.
1651Hu Y et.al. (2021). Arginine methyltransferase PRMT3 promote tumorigenesis through regulating c-MYC stabilization in colorectal cancer. Gene 791:145718.
1650Kempers L et.al. (2021). The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis. Angiogenesis :.
1649Galinski B et.al. (2021). XPO1 inhibition with selinexor synergizes with proteasome inhibition in neuroblastoma by targeting nuclear export of IkB. Transl Oncol 14:101114.
1648Krstic A et.al. (2021). A Chemo-Genomic Approach Identifies Diverse Epigenetic Therapeutic Vulnerabilities in MYCN-Amplified Neuroblastoma. Front Cell Dev Biol 9:612518.
1647Tang XX et.al. (2021). Clinical Relevance of CD4 Cytotoxic T Cells in High-Risk Neuroblastoma. Front Immunol 12:650427.
1646Arnone CM et.al. (2021). Oncolytic adenovirus and gene therapy with EphA2-BiTE for the treatment of pediatric high-grade gliomas. J Immunother Cancer 9:.
1645Tiago T et.al. (2021). Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor. Cell Death Dis 12:452.
1644Yang M et.al. (2021). Identification of a novel glycolysis-related gene signature for predicting the prognosis of osteosarcoma patients. Aging (Albany NY) 13:12896-12918.
1643Feng Y et.al. (2021). Predictive value of RAD51 on the survival and drug responsiveness of ovarian cancer. Cancer Cell Int 21:249.
1642Song H et.al. (2021). APE1 and SSRP1 is overexpressed in muscle invasive bladder cancer and associated with poor survival. Heliyon 7:e06756.
1641Choueiry F et.al. (2021). Integration of Metabolomics and Gene Expression Profiling Elucidates IL4I1 as Modulator of Ibrutinib Resistance in ABC-Diffuse Large B Cell Lymphoma. Cancers (Basel) 13:.
1640Hulstaert E et.al. (2021). Messenger RNA capture sequencing of extracellular RNA from human biofluids using a comprehensive set of spike-in controls. STAR Protoc 2:100475.
1639Zhang Z et.al. (2021). Fzd7/Wnt7b signaling contributes to stemness and chemoresistance in pancreatic cancer. Cancer Med :.
1638Tekin C et.al. (2021). Protease-activated receptor 1 drives and maintains ductal cell fates in the premalignant pancreas and ductal adenocarcinoma. Mol Oncol :.
1637Yang R et.al. (2021). POU2F2 regulates glycolytic reprogramming and glioblastoma progression via PDPK1-dependent activation of PI3K/AKT/mTOR pathway. Cell Death Dis 12:433.
1636Korholz K et.al. (2021). Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma. Cells 10:.
1635Koeniger A et.al. (2021). Activation of Cilia-Independent Hedgehog/GLI1 Signaling as a Novel Concept for Neuroblastoma Therapy. Cancers (Basel) 13:.
1634Nowak JK et.al. (2021). Ileal Lactase Expression Associates with Lactase Persistence Genotypes. Nutrients 13:.
1633Gamble LD et.al. (2021). A G316A Polymorphism in the Ornithine Decarboxylase Gene Promoter Modulates MYCN-Driven Childhood Neuroblastoma. Cancers (Basel) 13:.
1632Shin HJ et.al. (2021). Multiomic Analysis of Cereblon Expression and Its Prognostic Value in Kidney Renal Clear Cell Carcinoma, Lung Adenocarcinoma, and Skin Cutaneous Melanoma. J Pers Med 11:.
1631Zhang Q et.al. (2021). Novel role of CAP1 in regulation RNA polymerase II-mediated transcription elongation depends on its actin-depolymerization activity in nucleoplasm. Oncogene :.
1630Portillo M et.al. (2021). SIRT6-CBP-dependent nuclear Tau accumulation and its role in protein synthesis. Cell Rep 35:109035.
1629Nunez-Carpintero I et.al. (2021). The multilayer community structure of medulloblastoma. iScience 24:102365.
1628Tas ML et.al. (2021). Refractory Stage M Ganglioneuroblastoma With Bone Metastases and a Favorable, Chronic Course of Disease: Description of a Patient Cohort. J Pediatr Hematol Oncol :.
1627Malone CF et.al. (2021). Selective modulation of a pan-essential protein as a therapeutic strategy in cancer. Cancer Discov :.
1626Xiang S et.al. (2021). Targeting Cul3-scaffold E3 ligase complex via KLHL substrate adaptors for cancer therapy. Pharmacol Res :105616.
1625Lee IN et.al. (2021). Elevated XRCC5 expression level can promote temozolomide resistance and predict poor prognosis in glioblastoma. Oncol Lett 21:443.
1624Vernooij L et.al. (2021). High-throughput screening identifies idasanutlin as a resensitizing drug for venetoclax-resistant neuroblastoma cells. Mol Cancer Ther :.
1623Wood L et.al. (2021). Combining inhibitors of Brd4 and cyclin-dependent kinase can decrease tumor growth in neuroblastoma with MYCN amplification. J Pediatr Surg :60215.
1622Sun Q et.al. (2021). FOXD1 Promotes Dedifferentiation and Targeted Therapy Resistance in Melanoma by Regulating the Expression of CTGF. Int J Cancer :.
1621Chen C et.al. (2021). miR-135a Reduces Osteosarcoma Pulmonary Metastasis by Targeting Both BMI1 and KLF4. Front Oncol 11:620295.
1620Czerwinska P et.al. (2021). The Association between TIF1 Family Members and Cancer Stemness in Solid Tumors. Cancers (Basel) 13:.
1619Ranjan N et.al. (2021). The Tumor Suppressor MTUS1/ATIP1 Modulates Tumor Promotion in Glioma: Association with Epigenetics and DNA Repair. Cancers (Basel) 13:.
1618Megiorni F et.al. (2021). OTX015 Epi-Drug Exerts Antitumor Effects in Ovarian Cancer Cells by Blocking GNL3-Mediated Radioresistance Mechanisms: Cellular, Molecular and Computational Evidence. Cancers (Basel) 13:.
1617Jasinski-Bergner S et.al. (2021). Relevance of 2-O-Methylation and Pseudouridylation for the Malignant Melanoma. Cancers (Basel) 13:.
1616MacDonald TJ et.al. (2021). Liposome-Imipramine Blue Inhibits Sonic Hedgehog Medulloblastoma In Vivo. Cancers (Basel) 13:.
1615Subbarayan K et.al. (2021). Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues. Front Immunol 12:597399.
1614Dondero A et.al. (2021). Multiparametric flow cytometry highlights B7-H3 as a novel diagnostic/therapeutic target in GD2neg/low neuroblastoma variants. J Immunother Cancer 9:.
1613Yao B et.al. (2021). Hypoxia-induced cofilin 1 promotes hepatocellular carcinoma progression by regulating the PLD1/AKT pathway. Clin Transl Med 11:e366.
1612Subbarayan K et.al. (2021). Identification of a novel miR-21-3p/TGF-beta signaling-driven immune escape via the MHC class I/biglycan axis in tumor cells. Clin Transl Med 11:e306.
1611Ye M et.al. (2021). USP7 promotes hepatoblastoma progression through activation PI3K/AKT signaling pathway. Cancer Biomark :.
1610Wirsik NM et.al. (2021). TGF-beta activates pericytes via induction of the epithelial to mesenchymal transition protein SLUG in glioblastoma. Neuropathol Appl Neurobiol :.
1609Cao H et.al. (2021). BMPR2 expression level is correlated with low immune infiltration and predicts metastasis and poor survival in osteosarcoma. Oncol Lett 21:391.
1608Zhong X et.al. (2021). Prognostic Signature of Immune Genes and Immune-Related LncRNAs in Neuroblastoma: A Study Based on GEO and TARGET Datasets. Front Oncol 11:631546.
1607Nagy Z et.al. (2021). An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability. Nat Commun 12:1881.
1606Hupfer A et.al. (2021). The mammalian Hedgehog pathway is modulated by ANP32 proteins. Biochem Biophys Res Commun 553:78-84.
1605Bhatt AB et.al. (2021). Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer. Transl Oncol 14:101046.
1604Su F et.al. (2021). Progression of prostate carcinoma is promoted by adipose stromal cell-secreted CXCL12 signaling in prostate epithelium. NPJ Precis Oncol 5:26.
1603Caforio M et.al. (2021). GD2 redirected CAR T and activated NK-cell-mediated secretion of IFNgamma overcomes MYCN-dependent IDO1 inhibition, contributing to neuroblastoma cell immune escape. J Immunother Cancer 9:.
1602Satriyo PB et.al. (2021). 4-Acetylantroquinonol B downregulates CDK2/CDK4 expression and DNA damage response signaling for triggers programmed cell death in triple negative breast cancer cells. Toxicol Appl Pharmacol :115493.
1601Yu J et.al. (2021). Histone lactylation drives oncogenesis by facilitating m(6)A reader protein YTHDF2 expression in ocular melanoma. Genome Biol 22:85.
1600Keane S et.al. (2021). The loss of DLG2 isoform 7/8, but not isoform 2, is critical in advanced staged neuroblastoma. Cancer Cell Int 21:170.
1599Villanueva AA et.al. (2021). The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-beta1 and focal adhesion kinase activation. Cell Adh Migr 15:58-73.
1598Wang C et.al. (2021). Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis. Br J Cancer :.
1597Huang Z et.al. (2021). CDK1 promotes the stemness of lung cancer cells through interacting with Sox2. Clin Transl Oncol :.
1596Rezaei O et.al. (2021). Non-Coding RNAs Participate in the Pathogenesis of Neuroblastoma. Front Oncol 11:617362.
1595Weiss T et.al. (2021). Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8. Nat Commun 12:1624.
1594Farkas C et.al. (2021). Characterization of SALL2 Gene Isoforms and Targets Across Cell Types Reveals Highly Conserved Networks. Front Genet 12:613808.
1593Bownes LV et.al. (2021). EZH2 inhibition decreases neuroblastoma proliferation and in vivo tumor growth. PLoS One 16:e0246244.
1592Buzzetti M et.al. (2021). Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells. Sci Rep 11:5374.
1591Ishfaq M et.al. (2021). BTK Inhibition Reverses MDSC-Mediated Immunosuppression and Enhances Response to Anti-PDL1 Therapy in Neuroblastoma. Cancers (Basel) 13:.
1590Liao YM et.al. (2021). Low Expression of IL-15 and NKT in Tumor Microenvironment Predicts Poor Outcome of MYCN-Non-Amplified Neuroblastoma. J Pers Med 11:.
1589Qi C et.al. (2021). T cell immune regulator 1 is a prognostic marker associated with immune infiltration in glioblastoma multiforme. Oncol Lett 21:252.
1588Ruiz-Perez MV et.al. (2021). Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma. iScience 24:102128.
1587Slomp A et.al. (2021). Phosphatase PP2A enhances MCL-1 protein half-life in multiple myeloma cells. Cell Death Dis 12:229.
1586Afanasyeva EA et.al. (2021). Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma. Life Sci Alliance 4:.
1585He J et.al. (2021). MIG-6 is essential for promoting glucose metabolic reprogramming and tumor growth in triple-negative breast cancer. EMBO Rep :e50781.
1584Huo Z et.al. (2021). AQP1 Is Up-Regulated by Hypoxia and Leads to Increased Cell Water Permeability, Motility, and Migration in Neuroblastoma. Front Cell Dev Biol 9:605272.
1583Zhu J et.al. (2021). Prognostic role of EYA4 in lower grade glioma with IDH1 mutation and 1p19q co-deletion. World Neurosurg :.
1582Gao S et.al. (2021). BYSL contributes to tumor growth by cooperating with the mTORC2 complex in gliomas. Cancer Biol Med 18:88-104.
1581Hartlieb SA et.al. (2021). Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome. Nat Commun 12:1269.
1580Chen W et.al. (2021). MEF2A-mediated lncRNA HCP5 Inhibits Gastric Cancer Progression via MiR-106b-5p/p21 Axis. Int J Biol Sci 17:623-634.
1579Chen J et.al. (2021). Elevated LINC01550 induces the apoptosis and cell cycle arrest of melanoma. Med Oncol 38:32.
1578Roper SJ et.al. (2021). 3D spheroid models of paediatric SHH medulloblastoma mimic tumour biology, drug response and metastatic dissemination. Sci Rep 11:4259.
1577Dong Z et.al. (2021). GAS7 Deficiency Promotes Metastasis in MYCN-driven Neuroblastoma. Cancer Res :.
1576Filippova N et.al. (2021). Targeting the HuR oncogenic role with a new class of cytoplasmic dimerization inhibitors. Cancer Res :.
1575Korshunov A et.al. (2021). Integrated molecular analysis of adult Sonic Hedgehog (SHH)-activated medulloblastomas reveals two clinically relevant tumor subsets with VEGFA as potent prognostic indicator. Neuro Oncol :.
1574Van Damme H et.al. (2021). Therapeutic depletion of CCR8(+) tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy. J Immunother Cancer 9:.
1573Mahmood TB et.al. (2021). Evaluation of the Susceptibility and Fatality of Lung Cancer Patients towards the COVID-19 Infection: A Systemic Approach through Analyzing the ACE2, CXCL10 and their Co-expressed Genes. Curr Res Microb Sci :100022.
1572Pan X et.al. (2021). ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL-2 Pathway. Biomed Res Int 2021:8971728.
1571Gu Y et.al. (2021). Differential Expression of a Panel of Ten CNTN1-Associated Genes during Prostate Cancer Progression and the Predictive Properties of the Panel Towards Prostate Cancer Relapse. Genes (Basel) 12:.
1570Wirsching HG et.al. (2021). Negative allosteric modulators of metabotropic glutamate receptor 3 target the stem-like phenotype of glioblastoma. Mol Ther Oncolytics 20:166-174.
1569Waissi W et.al. (2021). Radiosensitizing Pancreatic Cancer with PARP Inhibitor and Gemcitabine: An In Vivo and a Whole-Transcriptome Analysis after Proton or Photon Irradiation. Cancers (Basel) 13:.
1568Szemes M et.al. (2021). Transcriptomic Analyses of MYCN-Regulated Genes in Anaplastic Wilms Tumour Cell Lines Reveals Oncogenic Pathways and Potential Therapeutic Vulnerabilities. Cancers (Basel) 13:.
1567Wickenhauser C et.al. (2021). Tumor Microenvironment, HLA Class I and APM Expression in HPV-Negative Oral Squamous Cell Carcinoma. Cancers (Basel) 13:.
1566Shi Y et.al. (2021). Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors. Nucleic Acids Res :.
1565Jacobs SM et.al. (2021). CXCR4 expression in glioblastoma tissue and the potential for PET imaging and treatment with [(68)Ga]Ga-Pentixafor /[(177)Lu]Lu-Pentixather. Eur J Nucl Med Mol Imaging :.
1564Xu H et.al. (2021). SMAR1 attenuates the stemness of osteosarcoma cells via through suppressing ABCG2 transcriptional activity. Environ Toxicol :.
1563Xiang T et.al. (2021). The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway. Cell Death Dis 12:150.
1562van den Ende T et.al. (2021). Neoadjuvant Chemoradiotherapy Combined with Atezolizumab for Resectable Esophageal Adenocarcinoma: A Single Arm Phase II Feasibility Trial (PERFECT). Clin Cancer Res :.
1561Gu Y et.al. (2021). Effective Prediction of Prostate Cancer Recurrence through the IQGAP1 Network. Cancers (Basel) 13:.
1560Putra V et.al. (2021). The RNA-helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma. Mol Oncol 15:1162-1179.
1559Zhang Y et.al. (2021). CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9. Cell Death Dis 12:118.
1558Floros KV et.al. (2021). MYCN-amplified neuroblastoma is addicted to iron and vulnerable to inhibition of the system Xc-/glutathione axis. Cancer Res :.
1557Berg TJ et.al. (2021). The irradiated brain microenvironment supports glioma stemness and survival via astrocyte-derived Transglutaminase 2. Cancer Res :.
1556Westendorp F et.al. (2021). Epithelium-derived Indian Hedgehog restricts stromal expression of ErbB family members that drive colonic tumor cell proliferation. Oncogene :.
1555Heise T et.al. (2021). RNA-Binding Protein La Mediates TGFbeta-Induced Epithelial to Mesenchymal Transition and Cancer Stem Cell Properties. Cancers (Basel) 13:.
1554Jager N et.al. (2021). Bioinformatics workflows for clinical applications in precision oncology. Semin Cancer Biol :.
1553Burghardt I et.al. (2021). Endoglin and TGF-beta signaling in glioblastoma. Cell Tissue Res :.
1552Milenova IE et.al. (2021). Oncolytic adenovirus ORCA-010 activates pro-inflammatory myeloid cells and facilitates T cell recruitment and activation by PD-1 blockade in melanoma. Hum Gene Ther :.
1551Shaik S et.al. (2021). REST promotes ETS1-dependent vascular growth in medulloblastoma. Mol Oncol :.
1550Kosti A et.al. (2021). Synergism of Proneurogenic miRNAs Provides a More Effective Strategy to Target Glioma Stem Cells. Cancers (Basel) 13:.
1549Thompson EM et.al. (2021). A Review of DUSP26: Structure, Regulation and Relevance in Human Disease. Int J Mol Sci 22:.
1548Abid K et.al. (2021). The noradrenergic profile of plasma metanephrine in neuroblastoma patients is reproduced in xenograft mice models and arise from PNMT downregulation. Oncotarget 12:49-60.
1547Canzonetta C et.al. (2021). Identification of neuroblastoma cell lines with uncommon TAZ(+)/mesenchymal stromal cell phenotype with strong suppressive activity on natural killer cells. J Immunother Cancer 9:.
1546Xu L et.al. (2021). EHMT2 inhibitor BIX-01294 induces endoplasmic reticulum stress mediated apoptosis and autophagy in diffuse large B-cell lymphoma cells. J Cancer 12:1011-1022.
1545Ferrucci V et.al. (2021). Prune-1 drives polarization of tumor-associated macrophages (TAMs) within the lung metastatic niche in triple-negative breast cancer. iScience 24:101938.
1544Xia Z et.al. (2021). GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner. Cell Death Dis 12:54.
1543Fang R et.al. (2021). EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma. Nat Commun 12:177.
1542Bierbaumer L et.al. (2021). YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells. Oncogenesis 10:2.
1541Qasim SL et.al. (2021). p21-activated kinases as viable therapeutic targets for the treatment of high-risk Ewing sarcoma. Oncogene :.
1540Borenas M et.al. (2021). ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation. EMBO J :e105784.
1539Fu D et.al. (2021). iTRAQ-based proteomic analysis of the molecular mechanisms and downstream effects of fatty acid synthase in osteosarcoma cells. J Clin Lab Anal :e23653.
1538Tornin J et.al. (2021). Osteosarcoma tissue-engineered model challenges oxidative stress therapy revealing promoted cancer stem cell properties. Free Radic Biol Med 164:107-118.
1537Moon SJ et.al. (2021). Bruceantin targets HSP90 to overcome resistance to hormone therapy in castration-resistant prostate cancer. Theranostics 11:958-973.
1536Carbo JM et.al. (2021). Pharmacologic Activation of LXR Alters the Expression Profile of Tumor-Associated Macrophages and the Abundance of Regulatory T Cells in the Tumor Microenvironment. Cancer Res 81:968-985.
1535Bedekovics T et.al. (2021). USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma. Cancer Res 81:1321-1331.
1534Chen KS et.al. (2021). NFIA and NFIB function as tumour suppressors in high-grade glioma in mice. Carcinogenesis 42:357-368.
1533Lu W et.al. (2021). SUMOylation is essential for Sirt2 tumor-suppressor function in neuroblastoma. Neoplasia 23:129-139.
1532Diao C et.al. (2021). SPT6 recruits SND1 to co-activate human telomerase reverse transcriptase to promote colon cancer progression. Mol Oncol 15:1180-1202.
1531Subbarayan K et.al. (2021). Expression and Clinical Significance of SARS-CoV-2 Human Targets in Neoplastic and Non-Neoplastic Lung Tissues. Curr Cancer Drug Targets 21:428-442.
1530Huang Y et.al. (2021). Combination of tumor necrosis factor-alpha and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells. Cancer Sci 112:715-724.
1529Xu Y et.al. (2021). Carboxy terminus of HSP70-interacting protein (CHIP) attenuates the stemness of thyroid cancer cells through decreasing OCT4 protein stability. Environ Toxicol 36:686-693.
1528Natsumeda M et.al. (2021). GLI3 Is Associated With Neuronal Differentiation in SHH-Activated and WNT-Activated Medulloblastoma. J Neuropathol Exp Neurol 80:129-136.
1527Qi C et.al. (2021). Thrombospondin-1 is a prognostic biomarker and is correlated with tumor immune microenvironment in glioblastoma. Oncol Lett 21:22.
1526Hu S et.al. (2021). Astragaloside IV inhibits cell proliferation and metastasis of breast cancer via promoting the long noncoding RNA TRHDE-AS1. J Nat Med 75:156-166.
1525Linke F et.al. (2021). 3D hydrogels reveal medulloblastoma subgroup differences and identify extracellular matrix subtypes that predict patient outcome. J Pathol 253:326-338.
1524Song X et.al. (2021). Synergistic targeting of CHK1 and mTOR in MYC-driven tumors. Carcinogenesis 42:448-460.
1523Zhang Z et.al. (2021). Regulation of ABCG2 expression by Wnt5a through FZD7 in human pancreatic cancer cells. Mol Med Rep 23:.
1522Lv H et.al. (2021). NAD(+) Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion. Cell Metab 33:110-127.e5.
1521Dasgupta A et.al. (2021). Targeting PAK4 Inhibits Ras-Mediated Signaling and Multiple Oncogenic Pathways in High-Risk Rhabdomyosarcoma. Cancer Res 81:199-212.
1520Story JY et.al. (2021). Bortezomib enhances cytotoxicity of ex vivo-expanded gamma delta T cells against acute myeloid leukemia and T-cell acute lymphoblastic leukemia. Cytotherapy 23:12-24.
1519Panzeri V et.al. (2021). The RNA-binding protein MEX3A is a prognostic factor and regulator of resistance to gemcitabine in pancreatic ductal adenocarcinoma. Mol Oncol 15:579-595.
1518Deng R et.al. (2021). BAP1 suppresses prostate cancer progression by deubiquitinating and stabilizing PTEN. Mol Oncol 15:279-298.
1517Sievers P et.al. (2021). A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR. Neuro Oncol 23:34-43.
1516Chen B et.al. (2021). Integrated Microarray to Identify the Hub miRNAs and Constructed miRNA-mRNA Network in Neuroblastoma Via Bioinformatics Analysis. Neurochem Res 46:197-212.
1515Lee TF et.al. (2021). TAZ negatively regulates the novel tumor suppressor ANKRD52 and promotes PAK1 dephosphorylation in lung adenocarcinomas. Biochim Biophys Acta Mol Cell Res 1868:118891.
1514Salemme V et.al. (2021). The p140Cap adaptor protein as a molecular hub to block cancer aggressiveness. Cell Mol Life Sci 78:1355-1367.
1513Fonseca LL et.al. (2021). RasGRP1 induces autophagy and transformation-associated changes in primary human keratinocytes. Transl Oncol 14:100880.
1512Xie R et.al. (2021). NONO Inhibits Lymphatic Metastasis of Bladder Cancer via Alternative Splicing of SETMAR. Mol Ther 29:291-307.
1511Naveed A et.al. (2021). NEAT1 polyA-modulating antisense oligonucleotides reveal opposing functions for both long non-coding RNA isoforms in neuroblastoma. Cell Mol Life Sci 78:2213-2230.
1510Pradhan S et.al. (2021). Evaluation of designs for renal drug studies based on the European Medicines Agency and Food and Drug Administration guidelines for drugs that are predominantly secreted. Br J Clin Pharmacol 87:1401-1410.
1509Chen B et.al. (2021). Analysis and identification of novel biomarkers involved in neuroblastoma via integrated bioinformatics. Invest New Drugs 39:52-65.
1508Haase J et.al. (2021). IGF2BP1 is the first positive marker for anaplastic thyroid carcinoma diagnosis. Mod Pathol 34:32-41.
1507Velletri T et.al. (2021). Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin. Cell Death Differ 28:156-169.
1506Sommer G et.al. (2021). Role of the RNA-binding protein La in cancer pathobiology. RNA Biol 18:218-236.
2020 (n=333)
1505Brex D et.al. (2020). LINC00483 Has a Potential Tumor-Suppressor Role in Colorectal Cancer Through Multiple Molecular Axes. Front Oncol 10:614455.
1504Wei M et.al. (2020). The Complex Roles and Therapeutic Implications of m(6)A Modifications in Breast Cancer. Front Cell Dev Biol 8:615071.
1503Huang J et.al. (2020). Rationally Designed Antibody Drug Conjugates Targeting the Breast Cancer-Associated Endothelium. ACS Biomater Sci Eng 6:2563-2569.
1502Rotman J et.al. (2020). PD-L1 and PD-L2 Expression in Cervical Cancer: Regulation and Biomarker Potential. Front Immunol 11:596825.
1501Hulstaert E et.al. (2020). Charting Extracellular Transcriptomes in The Human Biofluid RNA Atlas. Cell Rep 33:108552.
1500Barbagallo C et.al. (2020). LncRNA LINC00518 Acts as an Oncogene in Uveal Melanoma by Regulating an RNA-Based Network. Cancers (Basel) 12:.
1499Bruggeman JW et.al. (2020). Tumors Widely Express Hundreds of Embryonic Germline Genes. Cancers (Basel) 12:.
1498Wang Z et.al. (2020). PIK3CA Is Regulated by CUX1, Promotes Cell Growth and Metastasis in Bladder Cancer via Activating Epithelial-Mesenchymal Transition. Front Oncol 10:536072.
1497Huang J et.al. (2020). A Rationally Designed ICAM1 Antibody Drug Conjugate for Pancreatic Cancer. Adv Sci (Weinh) 7:2002852.
1496Tirinato L et.al. (2020). ROS and Lipid Droplet accumulation induced by high glucose exposure in healthy colon and Colorectal Cancer Stem Cells. Genes Dis 7:620-635.
1495Ke XX et.al. (2020). Deficiency of G9a Inhibits Cell Proliferation and Activates Autophagy via Transcriptionally Regulating c-Myc Expression in Glioblastoma. Front Cell Dev Biol 8:593964.
1494Nolan JC et.al. (2020). A Context-Dependent Role for MiR-124-3p on Cell Phenotype, Viability and Chemosensitivity in Neuroblastoma in vitro. Front Cell Dev Biol 8:559553.
1493Ognibene M et.al. (2020). Ezrin interacts with the tumor suppressor CHL1 and promotes neuronal differentiation of human neuroblastoma. PLoS One 15:e0244069.
1492Li Z et.al. (2020). PROTAC Bromodomain Inhibitor ARV-825 Displays Anti-Tumor Activity in Neuroblastoma by Repressing Expression of MYCN or c-Myc. Front Oncol 10:574525.
1491Ma M et.al. (2020). Role of FUT8 expression in clinicopathology and patient survival for various malignant tumor types: a systematic review and meta-analysis. Aging (Albany NY) 13:2212-2230.
1490Yuan X et.al. (2020). Erythrocyte membrane protein band 4.1-like 3 inhibits osteosarcoma cell invasion through regulation of Snai1-induced epithelial-to-mesenchymal transition. Aging (Albany NY) 13:1947-1961.
1489Masi M et.al. (2020). OXER1 and RACK1-associated pathway: a promising drug target for breast cancer progression. Oncogenesis 9:105.
1488Zhao Y et.al. (2020). Effective Inhibition of MYC-Amplified Group 3 Medulloblastoma Through Targeting EIF4A1. Cancer Manag Res 12:12473-12485.
1487Butera A et.al. (2020). The ZNF750-RAC1 axis as potential prognostic factor for breast cancer. Cell Death Discov 6:135.
1486Pan J et.al. (2020). Knockdown of Forkhead box A1 suppresses the tumorigenesis and progression of human colon cancer cells through regulating the phosphatase and tensin homolog/Akt pathway. J Int Med Res 48:300060520971453.
1485Tian C et.al. (2020). SKP1 promotes YAP-mediated colorectal cancer stemness via suppressing RASSF1. Cancer Cell Int 20:579.
1484Domenichini A et.al. (2020). Rhenium N-heterocyclic carbene complexes block growth of aggressive cancers by inhibiting FGFR J Exp Clin Cancer Res 39:276.
1483Hu XQ et.al. (2020). Gene expression profiles and protein-protein interaction networks in neuroblastoma with MEIS2 depletion. J BUON 25:2482-2489.
1482Kwak HJ et.al. (2020). Expression of ATP/GTP Binding Protein 1 Has Prognostic Value for the Clinical Outcomes in Non-Small Cell Lung Carcinoma. J Pers Med 10:.
1481Achiha T et.al. (2020). Activated leukocyte cell adhesion molecule expression correlates with the WNT subgroup in medulloblastoma and is involved in regulating tumor cell proliferation and invasion. PLoS One 15:e0243272.
1480Wang J et.al. (2020). Effective inhibition of MYC-amplified group 3 medulloblastoma by FACT-targeted curaxin drug CBL0137. Cell Death Dis 11:1029.
1479Kuster MM et.al. (2020). Epigenetic Inactivation of the Tumor Suppressor IRX1 Occurs Frequently in Lung Adenocarcinoma and Its Silencing Is Associated with Impaired Prognosis. Cancers (Basel) 12:.
1478Coronado E et.al. (2020). Intratumoral immunosuppression profiles in 11q-deleted neuroblastomas provide new potential therapeutic targets. Mol Oncol :.
1477Li M et.al. (2020). Methylation of the Promoter Region of the Tight Junction Protein-1 by DNMT1 Induces EMT-like Features in Multiple Myeloma. Mol Ther Oncolytics 19:197-207.
1476Melaiu O et.al. (2020). Cellular and gene signatures of tumor-infiltrating dendritic cells and natural-killer cells predict prognosis of neuroblastoma. Nat Commun 11:5992.
1475Taylor L et.al. (2020). Y-Box Binding Protein-1: A Neglected Target in Pediatric Brain Tumors? Mol Cancer Res :.
1474Colmenero-Repiso A et.al. (2020). Identification of VRK1 as a New Neuroblastoma Tumor Progression Marker Regulating Cell Proliferation. Cancers (Basel) 12:.
1473Zhang L et.al. (2020). SNORA72 Activates the Notch1/c-Myc Pathway to Promote Stemness Transformation of Ovarian Cancer Cells. Front Cell Dev Biol 8:583087.
1472Cai Y et.al. (2020). Prp19 Is an Independent Prognostic Marker and Promotes Neuroblastoma Metastasis by Regulating the Hippo-YAP Signaling Pathway. Front Oncol 10:575366.
1471Chai P et.al. (2020). Generation of onco-enhancer enhances chromosomal remodeling and accelerates tumorigenesis. Nucleic Acids Res 48:12135-12150.
1470McCann TS et.al. (2020). KDM5A and PHF2 positively control expression of pro-metastatic genes repressed by EWS/Fli1, and promote growth and metastatic properties in Ewing sarcoma. Oncotarget 11:3818-3831.
1469Somarelli JA et.al. (2020). A Comparative Oncology Drug Discovery Pipeline to Identify and Validate New Treatments for Osteosarcoma. Cancers (Basel) 12:.
1468Sarnella A et.al. (2020). A Novel Inhibitor of Carbonic Anhydrases Prevents Hypoxia-Induced TNBC Cell Plasticity. Int J Mol Sci 21:.
1467Song J et.al. (2020). A signature of 29 immune-related genes pairs to predict prognosis in patients with neuroblastoma. Int Immunopharmacol 88:106994.
1466Davis RS et.al. (2020). Roles for the FCRL6 Immunoreceptor in Tumor Immunology. Front Immunol 11:575175.
1465Tang Q et.al. (2020). TM4SF1 promotes EMT and cancer stemness via the Wnt/beta-catenin/SOX2 pathway in colorectal cancer. J Exp Clin Cancer Res 39:232.
1464Zhang S et.al. (2020). miR-766-3p Targeting BCL9L Suppressed Tumorigenesis, Epithelial-Mesenchymal Transition, and Metastasis Through the beta-Catenin Signaling Pathway in Osteosarcoma Cells. Front Cell Dev Biol 8:594135.
1463Sun C et.al. (2020). MDM2-P53 Signaling Pathway-Mediated Upregulation of CDC20 Promotes Progression of Human Diffuse Large B-Cell Lymphoma. Onco Targets Ther 13:10475-10487.
1462Garcia-Heredia JM et.al. (2020). Breast tumor cells promotes the horizontal propagation of EMT, stemness, and metastasis by transferring the MAP17 protein between subsets of neoplastic cells. Oncogenesis 9:96.
1461Liu D et.al. (2020). Soluble Compounds Released by Hypoxic Stroma Confer Invasive Properties to Pancreatic Ductal Adenocarcinoma. Biomedicines 8:.
1460Filippova N et.al. (2020). ELAVL1 Role in Cell Fusion and Tunneling Membrane Nanotube Formations with Implication to Treat Glioma Heterogeneity. Cancers (Basel) 12:.
1459Hossain MM et.al. (2020). Differential expression, function and prognostic value of miR-17-92 cluster in ER-positive and triple-negative breast cancer. Cancer Treat Res Commun 25:100224.
1458Zheng W et.al. (2020). RIG-I-Like Receptor LGP2 Is Required for Tumor Control by Radiotherapy. Cancer Res 80:5633-5641.
1457Balakrishnan I et.al. (2020). Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG. Cell Rep 33:108286.
1456Bhattacharya A et.al. (2020). SMAR1 repression by pluripotency factors and consequent chemoresistance in breast cancer stem-like cells is reversed by aspirin. Sci Signal 13:.
1455Cornet-Masana JM et.al. (2020). Histamine receptor 1 is expressed in leukaemic cells and affects differentiation sensitivity. J Cell Mol Med 24:13536-13541.
1454Czerwinska P et.al. (2020). Melanoma Stem Cell-Like Phenotype and Significant Suppression of Immune Response within a Tumor Are Regulated by TRIM28 Protein. Cancers (Basel) 12:.
1453Penco-Campillo M et.al. (2020). VEGFC negatively regulates the growth and aggressiveness of medulloblastoma cells. Commun Biol 3:579.
1452Ye M et.al. (2020). Downregulation of MEG3 promotes neuroblastoma development through FOXO1-mediated autophagy and mTOR-mediated epithelial-mesenchymal transition. Int J Biol Sci 16:3050-3061.
1451Yang G et.al. (2020). Upregulated mH2A1 serves as an unfavorable prognostic indicator and promotes the progress of hepatocellular carcinoma (HCC). Life Sci 263:118576.
1450Hassan MK et.al. (2020). EEF1A2 triggers stronger ERK mediated metastatic program in ER negative breast cancer cells than in ER positive cells. Life Sci 262:118553.
1449Ariey-Bonnet J et.al. (2020). In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor. Mol Oncol 14:3083-3099.
1448Yamashita M et.al. (2020). The role of SCF(Skp2) and SCF(beta-TrCP1/2) in the cerebellar granule cell precursors. Genes Cells 25:796-810.
1447Feng YC et.al. (2020). c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis. Nat Commun 11:4980.
1446Ando K et.al. (2020). CEP131 Abrogates CHK1 Inhibitor-Induced Replication Defects and Is Associated with Unfavorable Outcome in Neuroblastoma. J Oncol 2020:2752417.
1445Wang J et.al. (2020). Immunological and clinicopathological characteristics of C1RL in 2120 glioma patients. BMC Cancer 20:931.
1444Smit WL et.al. (2020). Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity. Proc Natl Acad Sci U S A 117:25560-25570.
1443Zhang Y et.al. (2020). Prognostic Value of the FOXK Family Expression in Patients with Locally Advanced Rectal Cancer Following Neoadjuvant Chemoradiotherapy. Onco Targets Ther 13:9185-9201.
1442Aravindan N et.al. (2020). Significance of hematopoietic surface antigen CD34 in neuroblastoma prognosis and the genetic landscape of CD34-expressing neuroblastoma CSCs. Cell Biol Toxicol :.
1441Hansson K et.al. (2020). Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma. Sci Transl Med 12:.
1440Siaw JT et.al. (2020). 11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma. Cell Rep 32:108171.
1439Perez M et.al. (2020). Sarcoma stratification by combined pH2AX and MAP17 (PDZK1IP1) levels for a better outcome on doxorubicin plus olaparib treatment. Signal Transduct Target Ther 5:195.
1438Mehmeti-Ajradini M et.al. (2020). Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer. Life Sci Alliance 3:.
1437Chramiec A et.al. (2020). Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety. Lab Chip 20:4357-4372.
1436Jemaa M et.al. (2020). Gene Expression Signature of Acquired Chemoresistance in Neuroblastoma Cells. Int J Mol Sci 21:.
1435Dong R et.al. (2020). Single-Cell Characterization of Malignant Phenotypes and Developmental Trajectories of Adrenal Neuroblastoma. Cancer Cell 38:716-733.e6.
1434Wu Y et.al. (2020). Systematic screening for potential therapeutic targets in osteosarcoma through a kinome-wide CRISPR-Cas9 library. Cancer Biol Med 17:782-794.
1433Silveira VS et.al. (2020). SHOC2 scaffold protein modulates daunorubicin-induced cell death through p53 modulation in lymphoid leukemia cells. Sci Rep 10:15193.
1432Blanas A et.al. (2020). FUT9-Driven Programming of Colon Cancer Cells towards a Stem Cell-Like State. Cancers (Basel) 12:.
1431Lazaridou MF et.al. (2020). Identification of miR-200a-5p targeting the peptide transporter TAP1 and its association with the clinical outcome of melanoma patients. Oncoimmunology 9:1774323.
1430Samad A et.al. (2020). Identification of angiotensin-converting enzyme 2 (ACE2) protein as the potential biomarker in SARS-CoV-2 infection-related lung cancer using computational analyses. Genomics 112:4912-4923.
1429Hartl L et.al. (2020). CCAAT/Enhancer-Binding Protein Delta (C/EBPdelta): A Previously Unrecognized Tumor Suppressor that Limits the Oncogenic Potential of Pancreatic Ductal Adenocarcinoma Cells. Cancers (Basel) 12:.
1428Thomaz A et.al. (2020). Neurotrophin Signaling in Medulloblastoma. Cancers (Basel) 12:.
1427Shim J et.al. (2020). YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma. Cancer Res 80:4741-4753.
1426Vivarelli S et.al. (2020). Role of the Transcription Factor Yin Yang 1 and Its Selectively Identified Target Survivin in High-Grade B-Cells Non-Hodgkin Lymphomas: Potential Diagnostic and Therapeutic Targets. Int J Mol Sci 21:.
1425Bloedjes TA et.al. (2020). AKT signaling restrains tumor suppressive functions of FOXO transcription factors and GSK3 kinase in multiple myeloma. Blood Adv 4:4151-4164.
1424Coebergh van den Braak RRJ et.al. (2020). Interconnectivity between molecular subtypes and tumor stage in colorectal cancer. BMC Cancer 20:850.
1423Lu Y et.al. (2020). Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK Pathway. Cancer Res 80:4655-4667.
1422Yu Z et.al. (2020). BRD8, which is negatively regulated by miR-876-3p, promotes the proliferation and apoptosis resistance of hepatocellular carcinoma cells via KAT5. Arch Biochem Biophys 693:108550.
1421Wang F et.al. (2020). Integrated Genome-Wide Methylation and Expression Analyses Reveal Key Regulators in Osteosarcoma. Comput Math Methods Med 2020:7067649.
1420Anantha J et.al. (2020). STRAP and NME1 Mediate the Neurite Growth-Promoting Effects of the Neurotrophic Factor GDF5. iScience 23:101457.
1419Shi H et.al. (2020). ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression. Sci Adv 6:eaaz3440.
1418Kanamori A et.al. (2020). Mint3 depletion restricts tumor malignancy of pancreatic cancer cells by decreasing SKP2 expression via HIF-1. Oncogene 39:6218-6230.
1417Cangelosi D et.al. (2020). Hypoxia Predicts Poor Prognosis in Neuroblastoma Patients and Associates with Biological Mechanisms Involved in Telomerase Activation and Tumor Microenvironment Reprogramming. Cancers (Basel) 12:.
1416Yang R et.al. (2020). E2F7-EZH2 axis regulates PTEN/AKT/mTOR signalling and glioblastoma progression. Br J Cancer 123:1445-1455.
1415Po A et.al. (2020). Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells. Sci Rep 10:13988.
1414Tekin C et.al. (2020). Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation. Cell Oncol (Dordr) 43:1161-1174.
1413Tombolan L et.al. (2020). Pediatric sarcomas display a variable EpCAM expression in a histology-dependent manner. Transl Oncol 13:100846.
1412Kim JH et.al. (2020). A novel nucleolin-binding peptide for Cancer Theranostics. Theranostics 10:9153-9171.
1411Zhang J et.al. (2020). Molecular markers associated with perineural invasion in pancreatic ductal adenocarcinoma. Oncol Lett 20:5.
1410Paronetto MP et.al. (2020). Exercise-mediated downregulation of MALAT1 expression and implications in primary and secondary cancer prevention. Free Radic Biol Med 160:28-39.
1409Hu Y et.al. (2020). Are Epithelial Ovarian Cancers of the Mesenchymal Subtype Actually Intraperitoneal Metastases to the Ovary? Front Cell Dev Biol 8:647.
1408Kosti A et.al. (2020). The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation. Genome Biol 21:195.
1407Ghalayini J et.al. (2020). Exploring the Therapeutic Potential of Protein Tyrosine Phosphatase 1B in hAPP-J20 Mouse Model of Alzheimers Disease. J Neurosci 40:6100-6102.
1406Erarslan-Uysal B et.al. (2020). Chromatin accessibility landscape of pediatric T-lymphoblastic leukemia and human T-cell precursors. EMBO Mol Med 12:e12104.
1405Nobre L et.al. (2020). Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma. Cell Rep Med 1:.
1404Ognibene M et.al. (2020). Roniciclib down-regulates stemness and inhibits cell growth by inducing nucleolar stress in neuroblastoma. Sci Rep 10:12902.
1403Liszka L et.al. (2020). Pan-p63 but not DeltaNp63 (p40) expression in undifferentiated carcinoma of the pancreas. Pol J Pathol 71:155-172.
1402de Sousa GR et.al. (2020). Should we keep rocking? Portraits from targeting Rho kinases in cancer. Pharmacol Res 160:105093.
1401Buoso E et.al. (2020). Ribosomes as a nexus between translation and cancer progression: Focus on ribosomal Receptor for Activated C Kinase 1 (RACK1) in breast cancer. Br J Pharmacol :.
1400Park J et.al. (2020). STAT3 is a key molecule in the oncogenic behavior of diffuse intrinsic pontine glioma. Oncol Lett 20:1989-1998.
1399Zhang Q et.al. (2020). Increased DEF6 expression is correlated with metastasis and poor prognosis in human osteosarcoma. Oncol Lett 20:1629-1640.
1398Jian L et.al. (2020). AGR3 promotes estrogen receptor-positive breast cancer cell proliferation in an estrogen-dependent manner. Oncol Lett 20:1441-1451.
1397Makino E et.al. (2020). Targeting Rad51 as a strategy for the treatment of melanoma cells resistant to MAPK pathway inhibition. Cell Death Dis 11:581.
1396Jasinski-Bergner S et.al. (2020). The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis. Int J Mol Sci 21:.
1395Alshangiti AM et.al. (2020). Association of distinct type 1 bone morphogenetic protein receptors with different molecular pathways and survival outcomes in neuroblastoma. Neuronal Signal 4:NS20200006.
1394Guo Q et.al. (2020). Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity. Mol Ther Nucleic Acids 21:527-541.
1393Bell JL et.al. (2020). Identification of RNA-Binding Proteins as Targetable Putative Oncogenes in Neuroblastoma. Int J Mol Sci 21:.
1392Pikatan NW et.al. (2020). Aberrantly expressed Brutons tyrosine kinase preferentially drives metastatic and stem cell-like phenotypes in neuroblastoma cells. Cell Oncol (Dordr) 43:1067-1084.
1391Illendula A et.al. (2020). Retinoic acid induces differentiation in neuroblastoma via ROR1 by modulating retinoic acid response elements. Oncol Rep 44:1013-1024.
1390Hingorani P et.al. (2020). Transcriptome analysis of desmoplastic small round cell tumors identifies actionable therapeutic targets: a report from the Childrens Oncology Group. Sci Rep 10:12318.
1389Hu J et.al. (2020). TRPS1 Confers Multidrug Resistance of Breast Cancer Cells by Regulating BCRP Expression. Front Oncol 10:934.
1388Prazeres PHDM et.al. (2020). Ablation of sensory nerves favours melanoma progression. J Cell Mol Med 24:9574-9589.
1387Simon Serrano S et.al. (2020). Inhibition of mitotic kinase Mps1 promotes cell death in neuroblastoma. Sci Rep 10:11997.
1386Zhang H et.al. (2020). Bone marrow mesenchymal stem cell-derived exosomal miR-206 inhibits osteosarcoma progression by targeting TRA2B. Cancer Lett 490:54-65.
1385Gassenmaier M et.al. (2020). Expression of DNA Methyltransferase 1 Is a Hallmark of Melanoma, Correlating with Proliferation and Response to B-Raf and Mitogen-Activated Protein Kinase Inhibition in Melanocytic Tumors. Am J Pathol 190:2155-2164.
1384Shen Z et.al. (2020). Transcription Factor EBF1 Over-Expression Suppresses Tumor Growth in vivo and in vitro via Modulation of the PNO1/p53 Pathway in Colorectal Cancer. Front Oncol 10:1035.
1383He X et.al. (2020). A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3. Mol Cancer 19:115.
1382Wang C et.al. (2020). Long Noncoding RNA LINC01134 Promotes Hepatocellular Carcinoma Metastasis via Activating AKT1S1 and NF-kappaB Signaling. Front Cell Dev Biol 8:429.
1381Zhao Q et.al. (2020). Acylglycerol kinase promotes the stemness of nasopharyngeal carcinoma cells by promoting beta-catenin translocation to the nucleus through activating PI3K/Akt pathway. Environ Toxicol 35:1299-1307.
1380Gao J et.al. (2020). Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC-Driven Cancer Progression. Cancer Res 80:3706-3718.
1379Qi C et.al. (2020). Serine Incorporator 2 (SERINC2) Expression Predicts an Unfavorable Prognosis of Low-Grade Glioma (LGG): Evidence from Bioinformatics Analysis. J Mol Neurosci 70:1521-1532.
1378Toledano-Fonseca M et.al. (2020). Circulating Cell-Free DNA-Based Liquid Biopsy Markers for the Non-Invasive Prognosis and Monitoring of Metastatic Pancreatic Cancer. Cancers (Basel) 12:.
1377Yang L et.al. (2020). SETD1A Promotes Proliferation of Castration-Resistant Prostate Cancer Cells via FOXM1 Transcription. Cancers (Basel) 12:.
1376Tiburcio PDB et.al. (2020). The neural stem-cell marker CD24 is specifically upregulated in IDH-mutant glioma. Transl Oncol 13:100819.
1375Lukosiute-Urboniene A et.al. (2020). Epigenetic Regulation of APAF-1 Through DNA Methylation in Pancreatic Cancer. Anticancer Res 40:3765-3779.
1374Schober SJ et.al. (2020). MHC Class I-Restricted TCR-Transgenic CD4(+) T Cells Against STEAP1 Mediate Local Tumor Control of Ewing Sarcoma In Vivo. Cells 9:.
1373Tang W et.al. (2020). beta1,4-Galactosyltransferase V Modulates Breast Cancer Stem Cells through Wnt/beta-catenin Signaling Pathway. Cancer Res Treat 52:1084-1102.
1372Park SR et.al. (2020). Tryptophanyl-tRNA Synthetase, a Novel Damage-Induced Cytokine, Significantly Increases the Therapeutic Effects of Endometrial Stem Cells. Mol Ther 28:2458-2472.
1371Kesherwani V et.al. (2020). Long non-coding RNA profiling of pediatric Medulloblastoma. BMC Med Genomics 13:87.
1370Abdelrasoul H et.al. (2020). Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia. Nat Commun 11:3194.
1369Zhang H et.al. (2020). Survival Association and Cell Cycle Effects of B7H3 in Neuroblastoma. J Korean Neurosurg Soc 63:707-716.
1368Suenaga Y et.al. (2020). De novo evolved gene product NCYM in the pathogenesis and clinical outcome of human neuroblastomas and other cancers. Jpn J Clin Oncol 50:839-846.
1367Sobral LM et.al. (2020). KDM3A/Ets1/MCAM axis promotes growth and metastatic properties in Rhabdomyosarcoma. Genes Cancer 11:53-65.
1366Wijaya J et.al. (2020). Using Pharmacology to Squeeze the Life Out of Childhood Leukemia, and Potential Strategies to Achieve Breakthroughs in Medulloblastoma Treatment. Pharmacol Rev 72:668-691.
1365Xu Y et.al. (2020). Deletion of Glutathione S-Transferase Omega 1 Activates Type I Interferon Genes and Downregulates Tissue Factor. Cancer Res 80:3692-3705.
1364Zhang J et.al. (2020). LAIR-1 overexpression inhibits epithelial-mesenchymal transition in osteosarcoma via GLUT1-related energy metabolism. World J Surg Oncol 18:136.
1363Zhou H et.al. (2020). Chaperone-mediated Autophagy Governs Progression of Papillary Thyroid Carcinoma via PPARgamma-SDF1/CXCR4 Signaling. J Clin Endocrinol Metab 105:.
1362Zeng H et.al. (2020). ZNF367-induced transcriptional activation of KIF15 accelerates the progression of breast cancer. Int J Biol Sci 16:2084-2093.
1361Zhou M et.al. (2020). KLF10 inhibits cell growth by regulating PTTG1 in multiple myeloma under the regulation of microRNA-106b-5p. Int J Biol Sci 16:2063-2071.
1360Dang TT et.al. (2020). Involvement of POLA2 in Double Strand Break Repair and Genotoxic Stress. Int J Mol Sci 21:.
1359Blijlevens M et.al. (2020). Silencing Core Spliceosome Sm Gene Expression Induces a Cytotoxic Splicing Switch in the Proteasome Subunit Beta 3 mRNA in Non-Small Cell Lung Cancer Cells. Int J Mol Sci 21:.
1358Perkail S et.al. (2020). BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice. Nat Commun 11:3018.
1357Mao R et.al. (2020). Ubiquitin C-terminal hydrolase L1 promotes expression of programmed cell death-ligand 1 in non-small-cell lung cancer cells. Cancer Sci 111:3174-3183.
1356Bellamy J et.al. (2020). Increased Efficacy of Histone Methyltransferase G9a Inhibitors Against MYCN-Amplified Neuroblastoma. Front Oncol 10:818.
1355Jian M et.al. (2020). A novel patient-derived organoids-based xenografts model for preclinical drug response testing in patients with colorectal liver metastases. J Transl Med 18:234.
1354Laneve P et.al. (2020). The Non-coding Side of Medulloblastoma. Front Cell Dev Biol 8:275.
1353Gao F et.al. (2020). The Membrane Protein Sortilin Can Be Targeted to Inhibit Pancreatic Cancer Cell Invasion. Am J Pathol 190:1931-1942.
1352Chen B et.al. (2020). Downregulation of PIF1, a potential new target of MYCN, induces apoptosis and inhibits cell migration in neuroblastoma cells. Life Sci 256:117820.
1351Bastiaenen VP et.al. (2020). A mouse model for peritoneal metastases of colorectal origin recapitulates patient heterogeneity. Lab Invest 100:1465-1474.
1350Wang Y et.al. (2020). Hepatocyte nuclear factor-1beta suppresses the stemness and migration of colorectal cancer cells through promoting miR-200b activity. Mol Carcinog 59:989-999.
1349Long L et.al. (2020). High expression of PKM2 synergizes with PD-L1 in tumor cells and immune cells to predict worse survival in human lung adenocarcinoma. J Cancer 11:4442-4452.
1348Auzmendi-Iriarte J et.al. (2020). Characterization of a new small-molecule inhibitor of HDAC6 in glioblastoma. Cell Death Dis 11:417.
1347Ding X et.al. (2020). The deubiquitinating enzyme UCHL1 promotes resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase. Theranostics 10:6048-6060.
1346Shen L et.al. (2020). Skipping of exon 10 in Axl pre-mRNA regulated by PTBP1 mediates invasion and metastasis process of liver cancer cells. Theranostics 10:5719-5735.
1345Xue S et.al. (2020). USP5 Promotes Metastasis in Non-Small Cell Lung Cancer by Inducing Epithelial-Mesenchymal Transition via Wnt/beta-Catenin Pathway. Front Pharmacol 11:668.
1344Li X et.al. (2020). PLAP -CAR T cells mediate high specific cytotoxicity against colon cancer cells. Front Biosci (Landmark Ed) 25:1765-1786.
1343Lee IN et.al. (2020). Knockdown of Amphiregulin Triggers Doxorubicin-Induced Autophagic and Apoptotic Death by Regulating Endoplasmic Reticulum Stress in Glioblastoma Cells. J Mol Neurosci 70:1461-1470.
1342Guo M et.al. (2020). MUC1 plays an essential role in tumor immunity of colorectal cancer stem cell vaccine. Int Immunopharmacol 85:106631.
1341Wu S et.al. (2020). UCP2 silencing in glioblastoma reduces cell proliferation and invasiveness by inhibiting p38 MAPK pathway. Exp Cell Res 394:112110.
1340Wang D et.al. (2020). Loss of 4.1N in epithelial ovarian cancer results in EMT and matrix-detached cell death resistance. Protein Cell :.
1339Vriend J et.al. (2020). Ubiquitin ligases and medulloblastoma: genetic markers of the four consensus subgroups identified through transcriptome datasets. Biochim Biophys Acta Mol Basis Dis 1866:165839.
1338Cai Q et.al. (2020). IGFBP-3/IGFBP-3 Receptor System as an Anti-Tumor and Anti-Metastatic Signaling in Cancer. Cells 9:.
1337Parodi S et.al. (2020). The Over-Expression of E2F3 Might Serve as Prognostic Marker for Neuroblastoma Patients with Stage 4S Disease. Diagnostics (Basel) 10:.
1336Yu H et.al. (2020). LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2. Cell Death Differ 27:3021-3036.
1335Orlandella FM et.al. (2020). miR-622 is a novel potential biomarker of breast carcinoma and impairs motility of breast cancer cells through targeting NUAK1 kinase. Br J Cancer 123:426-437.
1334Dorn A et.al. (2020). LINC00261 Is Differentially Expressed in Pancreatic Cancer Subtypes and Regulates a Pro-Epithelial Cell Identity. Cancers (Basel) 12:.
1333Kang JY et.al. (2020). Neuropilin1 Expression Acts as a Prognostic Marker in Stomach Adenocarcinoma by Predicting the Infiltration of Treg Cells and M2 Macrophages. J Clin Med 9:.
1332Gil M et.al. (2020). Systematic Multiomic Analysis of Ly75 Gene Expression and Its Prognostic Value Through the Infiltration of Natural Killer (NK) Cells in Skin Cutaneous Melanoma. J Clin Med 9:.
1331Adam K et.al. (2020). The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis. Int J Mol Sci 21:.
1330Candido MF et.al. (2020). NF-small ka, CyrillicB inhibition by DHMEQ: in vitro antiproliferative effects on pilocytic astrocytoma and concise review of the current literature. Childs Nerv Syst 36:2675-2684.
1329Bremer J et.al. (2020). A single supratentorial high-grade neuroepithelial tumor with two distinct BCOR mutations, exceptionally long complete remission and survival. Pediatr Blood Cancer 67:e28384.
1328Bobyn A et.al. (2020). Ancestry and frequency of genetic variants in the general population are confounders in the characterization of germline variants linked to cancer. BMC Med Genet 21:92.
1327Liu X et.al. (2020). HDAC10 Is Positively Associated With PD-L1 Expression and Poor Prognosis in Patients With NSCLC. Front Oncol 10:485.
1326Chaturvedi NK et.al. (2020). A Novel Combination Approach Targeting an Enhanced Protein Synthesis Pathway in MYC-driven (Group 3) Medulloblastoma. Mol Cancer Ther 19:1351-1362.
1325Hu Z et.al. (2020). Downregulation of GLYR1 contributes to microsatellite instability colorectal cancer by targeting p21 via the p38MAPK and PI3K/AKT pathways. J Exp Clin Cancer Res 39:76.
1324Lin Z et.al. (2020). RNA m(6) A methylation regulates sorafenib resistance in liver cancer through FOXO3-mediated autophagy. EMBO J 39:e103181.
1323Liu Y et.al. (2020). KIF23 activated Wnt/beta-catenin signaling pathway through direct interaction with Amer1 in gastric cancer. Aging (Albany NY) 12:8372-8396.
1322Kim KK et.al. (2020). Role of trypsin and protease-activated receptor-2 in ovarian cancer. PLoS One 15:e0232253.
1321Yu X et.al. (2020). Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation. J Hematol Oncol 13:40.
1320Wang TX et.al. (2020). Identification of aberrantly methylated differentially expressed genes targeted by differentially expressed miRNA in osteosarcoma. Ann Transl Med 8:373.
1319Chen X et.al. (2020). Bcl-3 promotes Wnt signaling by maintaining the acetylation of beta-catenin at lysine 49 in colorectal cancer. Signal Transduct Target Ther 5:52.
1318Munoz-Galvan S et.al. (2020). PAI1 is a Marker of Bad Prognosis in Rectal Cancer but Predicts a Better Response to Treatment with PIM Inhibitor AZD1208. Cells 9:.
1317Chen D et.al. (2020). LIN28B promotes neuroblastoma metastasis and regulates PDZ binding kinase. Neoplasia 22:231-241.
1316Andolfo I et.al. (2020). Kinome multigenic panel identified novel druggable EPHB4-V871I somatic variant in high-risk neuroblastoma. J Cell Mol Med 24:6459-6471.
1315Topi G et.al. (2020). Tumour-suppressive effect of oestrogen receptor beta in colorectal cancer patients, colon cancer cells, and a zebrafish model. J Pathol 251:297-309.
1314Shen Y et.al. (2020). LncRNA KCNQ1OT1 sponges miR-34c-5p to promote osteosarcoma growth via ALDOA enhanced aerobic glycolysis. Cell Death Dis 11:278.
1313Kovar H et.al. (2020). The YAP/TAZ Pathway in Osteogenesis and Bone Sarcoma Pathogenesis. Cells 9:.
1312Li TF et.al. (2020). Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer. Cancer Cell Int 20:123.
1311Dos Santos Klinger PH et.al. (2020). Arsenic Trioxide exerts cytotoxic and radiosensitizing effects in pediatric Medulloblastoma cell lines of SHH Subgroup. Sci Rep 10:6836.
1310Zhao Y et.al. (2020). NUSAP1 potentiates chemoresistance in glioblastoma through its SAP domain to stabilize ATR. Signal Transduct Target Ther 5:44.
1309Aldaregia J et.al. (2020). Erbb4 Is Required for Cerebellar Developmentand Malignant Phenotype of Medulloblastoma. Cancers (Basel) 12:.
1308Cassandri M et.al. (2020). ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes. Oncogene 39:4331-4343.
1307Keane S et.al. (2020). Low DLG2 gene expression, a link between 11q-deleted and MYCN-amplified neuroblastoma, causes forced cell cycle progression, and predicts poor patient survival. Cell Commun Signal 18:65.
1306Martin SB et.al. (2020). Leucine and branched-chain amino acid metabolism contribute to the growth of bone sarcomas by regulating AMPK and mTORC1 signaling. Biochem J 477:1579-1599.
1305Lan Z et.al. (2020). The Interaction Between lncRNA SNHG6 and hnRNPA1 Contributes to the Growth of Colorectal Cancer by Enhancing Aerobic Glycolysis Through the Regulation of Alternative Splicing of PKM. Front Oncol 10:363.
1304Zhang D et.al. (2020). The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages. Signal Transduct Target Ther 5:24.
1303Koneru B et.al. (2020). Telomere Maintenance Mechanisms Define Clinical Outcome in High-Risk Neuroblastoma. Cancer Res 80:2663-2675.
1302Li C et.al. (2020). Long non-coding RNA DLX6-AS1 regulates neuroblastoma progression by targeting YAP1 via miR-497-5p. Life Sci 252:117657.
1301Chung PED et.al. (2020). Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy. Nat Commun 11:1825.
1300Jiang S et.al. (2020). Identification of tumorigenicity-associated genes in osteosarcoma cell lines based on bioinformatic analysis and experimental validation. J Cancer 11:3623-3633.
1299Berning P et.al. (2020). The Receptor Tyrosine Kinase RON and Its Isoforms as Therapeutic Targets in Ewing Sarcoma. Cancers (Basel) 12:.
1298Deng Y et.al. (2020). High SPRR1A expression is associated with poor survival in patients with colon cancer. Oncol Lett 19:3417-3424.
1297Parrilla A et.al. (2020). Aurora Borealis (Bora), Which Promotes Plk1 Activation by Aurora A, Has an Oncogenic Role in Ovarian Cancer. Cancers (Basel) 12:.
1296Thiruvalluvan A et.al. (2020). DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis. Mol Cell 78:346-358.e9.
1295Jane EP et.al. (2020). Targeting NAD(+) Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance. Mol Cancer Res 18:1004-1017.
1294Tran HM et.al. (2020). Upregulation of Protein Synthesis and Proteasome Degradation Confers Sensitivity to Proteasome Inhibitor Bortezomib in Myc-Atypical Teratoid/Rhabdoid Tumors. Cancers (Basel) 12:.
1293Li Z et.al. (2020). The dual role of BI 2536, a small-molecule inhibitor that targets PLK1, in induction of apoptosis and attenuation of autophagy in neuroblastoma cells. J Cancer 11:3274-3287.
1292Schubert NA et.al. (2020). Systematic target actionability reviews of preclinical proof-of-concept papers to match targeted drugs to paediatric cancers. Eur J Cancer 130:168-181.
1291Rotman J et.al. (2020). Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of cDC1 and CD8(+) T Cells and Elevated beta-Catenin Activation Compared with Squamous Cell Carcinoma. Clin Cancer Res 26:3791-3802.
1290Lu F et.al. (2020). Downregulation of TMOD1 promotes cell motility and cell proliferation in cervical cancer cells. Oncol Lett 19:3339-3348.
1289Zhang Y et.al. (2020). FBXW4 Acts as a Protector of FOLFOX-Based Chemotherapy in Metastatic Colorectal Cancer Identified by Co-Expression Network Analysis. Front Genet 11:113.
1288Szemes M et.al. (2020). A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma. Cells 9:.
1287Reaman G et.al. (2020). Crossing Oceans: Preclinical Collaboration to Improve Pediatric Drug Development. Am Soc Clin Oncol Educ Book 40:1-8.
1286Ding J et.al. (2020). Long Non-coding RNA LINC01503 Promotes Gastric Cancer Cell Proliferation and Invasion by Regulating Wnt Signaling. Dig Dis Sci :.
1285Du W et.al. (2020). MiR-195-5p is a Potential Factor Responsible for CPNE1 Differential Expression between Subtypes of Non-Small Cell Lung Cancer. J Cancer 11:2610-2620.
1284Galenkamp KMO et.al. (2020). Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells. Cancer Discov 10:822-835.
1283Louis-Brennetot C et.al. (2020). High CD44 expression is not a prognosis marker in patients with high-risk neuroblastoma. EBioMedicine 53:102702.
1282Camero S et.al. (2020). BET inhibition therapy counteracts cancer cell survival, clonogenic potential and radioresistance mechanisms in rhabdomyosarcoma cells. Cancer Lett 479:71-88.
1281Kavazovic I et.al. (2020). Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity. PLoS Biol 18:e3000648.
1280Steins A et.al. (2020). High-grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF-1. EMBO Rep 21:e48780.
1279Meel MH et.al. (2020). Combined Therapy of AXL and HDAC Inhibition Reverses Mesenchymal Transition in Diffuse Intrinsic Pontine Glioma. Clin Cancer Res 26:3319-3332.
1278Wu PK et.al. (2020). Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability. Sci Signal 13:.
1277Belisario DC et.al. (2020). ABCA1/ABCB1 Ratio Determines Chemo Cells 9:.
1276Banerjee S et.al. (2020). Pyridoxine enhances chemo-responsiveness of breast cancer stem cells via redox reconditioning. Free Radic Biol Med 152:152-165.
1275Gunnarsdottir FB et.al. (2020). Inflammatory macrophage derived TNFalpha downregulates estrogen receptor alpha via FOXO3a inactivation in human breast cancer cells. Exp Cell Res 390:111932.
1274Kanchan RK et.al. (2020). MiR-1253 exerts tumor-suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7-H3). Brain Pathol 30:732-745.
1273Brack E et.al. (2020). Fenretinide induces a new form of dynamin-dependent cell death in pediatric sarcoma. Cell Death Differ 27:2500-2516.
1272Yang J et.al. (2020). Antibiotic tigecycline inhibits cell proliferation, migration and invasion via down-regulating CCNE2 in pancreatic ductal adenocarcinoma. J Cell Mol Med 24:4245-4260.
1271Prieto-Garcia C et.al. (2020). Maintaining protein stability of Np63 via USP28 is required by squamous cancer cells. EMBO Mol Med 12:e11101.
1270Dong Z et.al. (2020). FOXO3aSIRT6 axis suppresses aerobic glycolysis in melanoma. Int J Oncol 56:728-742.
1269Salerno D et.al. (2020). Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription. Gut :.
1268Quintanal-Villalonga A et.al. (2020). FGFR1 and FGFR4 oncogenicity depends on n-cadherin and their co-expression may predict FGFR-targeted therapy efficacy. EBioMedicine 53:102683.
1267Niesen J et.al. (2020). Pik3ca mutations significantly enhance the growth of SHH medulloblastoma and lead to metastatic tumour growth in a novel mouse model. Cancer Lett 477:10-18.
1266Yang X et.al. (2020). METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST. Mol Cancer 19:46.
1265Schnetz M et.al. (2020). The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth. Cancers (Basel) 12:.
1264Zhou L et.al. (2020). NOTCH4 maintains quiescent mesenchymal-like breast cancer stem cells via transcriptionally activating SLUG and GAS1 in triple-negative breast cancer. Theranostics 10:2405-2421.
1263Avitabile M et.al. (2020). Association of PARP1 polymorphisms with response to chemotherapy in patients with high-risk neuroblastoma. J Cell Mol Med 24:4072-4081.
1262Wagner M et.al. (2020). Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s. Cell Rep 30:2743-2757.e5.
1261Kim KK et.al. (2020). Development of Potent Forchlorfenuron Analogs and Their Cytotoxic Effect in Cancer Cell Lines. Sci Rep 10:3241.
1260Jafarzadeh M et.al. (2020). Epigenetically silenced LINC02381 functions as a tumor suppressor by regulating PI3K-Akt signaling pathway. Biochimie 171-172:63-71.
1259Jiang Y et.al. (2020). BICD1 functions as a prognostic biomarker and promotes hepatocellular carcinoma progression. Pathol Res Pract 216:152858.
1258Zhao Z et.al. (2020). The PLAGL2/MYCN/miR-506-3p interplay regulates neuroblastoma cell fate and associates with neuroblastoma progression. J Exp Clin Cancer Res 39:41.
1257Khanna A et.al. (2020). Constitutive CHK1 Expression Drives a pSTAT3-CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth. Mol Cancer Res 18:709-722.
1256Guo YF et.al. (2020). Inhibition of the ALDH18A1-MYCN positive feedback loop attenuates MYCN-amplified neuroblastoma growth. Sci Transl Med 12:.
1255Mekhloufi A et.al. (2020). Bone Marrow Stromal Cell-Derived IL-8 Upregulates PVR Expression on Multiple Myeloma Cells via NF-kB Transcription Factor. Cancers (Basel) 12:.
1254Goroshchuk O et.al. (2020). Targeting Plk1 with siRNNs in primary cells from pediatric B-cell acute lymphoblastic leukemia patients. Sci Rep 10:2688.
1253Liu Z et.al. (2020). CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG. Nat Commun 11:911.
1252Yamashita D et.al. (2020). Targeting glioma-initiating cells via the tyrosine metabolic pathway. J Neurosurg :1-12.
1251da Cunha Jaeger M et.al. (2020). HDAC and MAPK/ERK Inhibitors Cooperate To Reduce Viability and Stemness in Medulloblastoma. J Mol Neurosci 70:981-992.
1250Aichmuller CF et.al. (2020). Pilocytic Astrocytoma demethylation and transcriptional landscapes link bZIP transcription factors to immune response. Neuro Oncol :.
1249Di Magno L et.al. (2020). Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module. Cell Rep 30:1735-1752.e7.
1248Cimmino F et.al. (2020). Functional characterization of full-length BARD1 strengthens its role as a tumor suppressor in neuroblastoma. J Cancer 11:1495-1504.
1247Richter AM et.al. (2020). RASSF10 is frequently epigenetically inactivated in kidney cancer and its knockout promotes neoplasia in cancer prone mice. Oncogene 39:3114-3127.
1246Tang K et.al. (2020). Shear stress stimulates integrin beta1 trafficking and increases directional migration of cancer cells via promoting deacetylation of microtubules. Biochim Biophys Acta Mol Cell Res 1867:118676.
1245Chen XS et.al. (2020). UCH-L1-mediated Down-regulation of Estrogen Receptor alpha Contributes to Insensitivity to Endocrine Therapy for Breast Cancer. Theranostics 10:1833-1848.
1244Mohapatra P et.al. (2020). WNT5A-Induced Activation of the Protein Kinase C Substrate MARCKS Is Required for Melanoma Cell Invasion. Cancers (Basel) 12:.
1243Li Y et.al. (2020). Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia. Cell Death Dis 11:102.
1242Sun L et.al. (2020). LncRNA RUNX1-IT1 which is downregulated by hypoxia-driven histone deacetylase 3 represses proliferation and cancer stem-like properties in hepatocellular carcinoma cells. Cell Death Dis 11:95.
1241Palombo R et.al. (2020). Poison-Exon Inclusion in DHX9 Reduces Its Expression and Sensitizes Ewing Sarcoma Cells to Chemotherapeutic Treatment. Cells 9:.
1240Li YH et.al. (2020). PRMT5-TRIM21 interaction regulates the senescence of osteosarcoma cells by targeting the TXNIP/p21 axis. Aging (Albany NY) 12:2507-2529.
1239Song X et.al. (2020). Role of SSH1 in colorectal cancer prognosis and tumor progression. J Gastroenterol Hepatol 35:1180-1188.
1238Bufalieri F et.al. (2020). The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I. Cancers (Basel) 12:.
1237Richter GHS et.al. (2020). Combined Inhibition of Epigenetic Readers and Transcription Initiation Targets the EWS-ETS Transcriptional Program in Ewing Sarcoma. Cancers (Basel) 12:.
1236Andersson MK et.al. (2020). ATR is a MYB regulated gene and potential therapeutic target in adenoid cystic carcinoma. Oncogenesis 9:5.
1235Ballabio C et.al. (2020). Modeling medulloblastoma in vivo and with human cerebellar organoids. Nat Commun 11:583.
1234Lu Y et.al. (2020). TRIB3 confers glioma cell stemness via interacting with beta-catenin. Environ Toxicol 35:697-706.
1233Li X et.al. (2020). Critical Role of Matrix Metalloproteinase 14 in Adipose Tissue Remodeling during Obesity. Mol Cell Biol 40:.
1232Zhang Y et.al. (2020). Overexpressed CES2 has prognostic value in CRC and knockdown CES2 reverses L-OHP-resistance in CRC cells by inhibition of the PI3K signaling pathway. Exp Cell Res 389:111856.
1231Yu M et.al. (2020). CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint. Nat Commun 11:515.
1230Karim MA et.al. (2020). A Multi-Omics Analysis of Bone Morphogenetic Protein 5 (BMP5) mRNA Expression and Clinical Prognostic Outcomes in Different Cancers Using Bioinformatics Approaches. Biomedicines 8:.
1229Sommer J et.al. (2020). Four-And-A-Half LIM-Domain Protein 2 (FHL2) Deficiency Aggravates Cholestatic Liver Injury. Cells 9:.
1228Ognibene M et.al. (2020). Identification of a minimal region of loss on chromosome 6q27 associated with poor survival of high-risk neuroblastoma patients. Cancer Biol Ther 21:391-399.
1227Meijer BJ et.al. (2020). ATF2 and ATF7 Are Critical Mediators of Intestinal Epithelial Repair. Cell Mol Gastroenterol Hepatol 10:23-42.
1226Wijaya J et.al. (2020). An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling. Cancer Res 80:1524-1537.
1225Wang F et.al. (2020). WDR5-Myc axis promotes the progression of glioblastoma and neuroblastoma by transcriptional activating CARM1. Biochem Biophys Res Commun 523:699-706.
1224Persson CU et.al. (2020). ARNT-dependent HIF-2 transcriptional activity is not sufficient to regulate downstream target genes in neuroblastoma. Exp Cell Res 388:111845.
1223Aldaz P et.al. (2020). SOX9 promotes tumor progression through the axis BMI1-p21(CIP). Sci Rep 10:357.
1222Mus LM et.al. (2020). The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness. Sci Rep 10:218.
1221Chen X et.al. (2020). alpha5-nAChR contributes to epithelial-mesenchymal transition and metastasis by regulating Jab1/Csn5 signalling in lung cancer. J Cell Mol Med 24:2497-2506.
1220Munoz-Galvan S et.al. (2020). Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness. Mol Cancer 19:7.
1219Saric N et.al. (2020). The AHR pathway represses TGFbeta-SMAD3 signalling and has a potent tumour suppressive role in SHH medulloblastoma. Sci Rep 10:148.
1218Wang G et.al. (2020). Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice. Nat Commun 11:220.
1217Hsieh MJ et.al. (2020). Basic fibroblast growth factor promotes doxorubicin resistance in chondrosarcoma cells by affecting XRCC5 expression. Mol Carcinog 59:293-303.
1216Gritsenko PG et.al. (2020). p120-catenin-dependent collective brain infiltration by glioma cell networks. Nat Cell Biol 22:97-107.
1215Huang M et.al. (2020). Epigenetic Targeting of TERT-Associated Gene Expression Signature in Human Neuroblastoma with TERT Overexpression. Cancer Res 80:1024-1035.
1214Hnit SST et.al. (2020). Transcriptional regulation of G2/M regulatory proteins and perturbation of G2/M Cell cycle transition by a traditional Chinese medicine recipe. J Ethnopharmacol 251:112526.
1213Ommer J et.al. (2020). Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death. Cancer Res 80:832-842.
1212Shen Z et.al. (2020). SNX16 activates c-Myc signaling by inhibiting ubiquitin-mediated proteasomal degradation of eEF1A2 in colorectal cancer development. Mol Oncol 14:387-406.
1211Zhao PF et.al. (2020). LPA receptor1 antagonists as anticancer agents suppress human lung tumours. Eur J Pharmacol 868:172886.
1210Park SR et.al. (2020). Sonic Hedgehog, a Novel Endogenous Damage Signal, Activates Multiple Beneficial Functions of Human Endometrial Stem Cells. Mol Ther 28:452-465.
1209Vrenken KS et.al. (2020). The transcriptional repressor SNAI2 impairs neuroblastoma differentiation and inhibits response to retinoic acid therapy. Biochim Biophys Acta Mol Basis Dis 1866:165644.
1208Zhang G et.al. (2020). Elevated GALNT10 expression identifies immunosuppressive microenvironment and dismal prognosis of patients with high grade serous ovarian cancer. Cancer Immunol Immunother 69:175-187.
1207Koche RP et.al. (2020). Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma. Nat Genet 52:29-34.
1206Green AL et.al. (2020). BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway. Oncogene 39:2305-2327.
1205Gagliardi F et.al. (2020). Enhanced SPARCL1 expression in cancer stem cells improves preclinical modeling of glioblastoma by promoting both tumor infiltration and angiogenesis. Neurobiol Dis 134:104705.
1204Gao J et.al. (2020). Up-regulated LINC00261 predicts a poor prognosis and promotes a metastasis by EMT process in cholangiocarcinoma. Pathol Res Pract 216:152733.
1203Qin X et.al. (2020). Matrix stiffness modulates ILK-mediated YAP activation to control the drug resistance of breast cancer cells. Biochim Biophys Acta Mol Basis Dis 1866:165625.
1202Capasso M et.al. (2020). Transcription Factors Involved in Tumorigenesis Are Over-Represented in Mutated Active DNA-Binding Sites in Neuroblastoma. Cancer Res 80:382-393.
1201Rehwald C et.al. (2020). The iron load of lipocalin-2 (LCN-2) defines its pro-tumour function in clear-cell renal cell carcinoma. Br J Cancer 122:421-433.
1200Zhang W et.al. (2020). miR-1225-5p Functions as a Tumor Suppressor in Osteosarcoma by Targeting Sox9. DNA Cell Biol 39:78-91.
1199Chen KS et.al. (2020). Transcription factors NFIA and NFIB induce cellular differentiation in high-grade astrocytoma. J Neurooncol 146:41-53.
1198Amoroso L et.al. (2020). Genomic coamplification of CDK4/MDM2/FRS2 is associated with very poor prognosis and atypical clinical features in neuroblastoma patients. Genes Chromosomes Cancer 59:277-285.
1197Liu Q et.al. (2020). ATAD2 predicts poor outcomes in patients with ovarian cancer and is a marker of proliferation. Int J Oncol 56:219-231.
1196Andolfo I et.al. (2020). Gain-of-function mutations in PIEZO1 directly impair hepatic iron metabolism via the inhibition of the BMP/SMADs pathway. Am J Hematol 95:188-197.
1195Tas ML et.al. (2020). Neuroblastoma stage 4S: Tumor regression rate and risk factors of progressive disease. Pediatr Blood Cancer 67:e28061.
1194Steins A et.al. (2020). Rapid stromal remodeling by short-term VEGFR2 inhibition increases chemotherapy delivery in esophagogastric adenocarcinoma. Mol Oncol 14:704-720.
1193Wang J et.al. (2020). BRD4 promotes glioma cell stemness via enhancing miR-142-5p-mediated activation of Wnt/beta-catenin signaling. Environ Toxicol 35:368-376.
1192Qian M et.al. (2020). BCL11B regulates MICA/B-mediated immune response by acting as a competitive endogenous RNA. Oncogene 39:1514-1526.
1191Bong AHL et.al. (2020). NCS-1 expression is higher in basal breast cancers and regulates calcium influx and cytotoxic responses to doxorubicin. Mol Oncol 14:87-104.
1190Li J et.al. (2020). CDGSH Iron Sulfur Domain 2 Deficiency Inhibits Cell Proliferation and Induces Cell Differentiation of Neuroblastoma. Pathol Oncol Res 26:1725-1733.
1189Mercatelli N et.al. (2020). Small molecule inhibition of Ewing sarcoma cell growth via targeting the long non coding RNA HULC. Cancer Lett 469:111-123.
1188Chava S et.al. (2020). miR-15a-5p, miR-15b-5p, and miR-16-5p inhibit tumor progression by directly targeting MYCN in neuroblastoma. Mol Oncol 14:180-196.
1187Kosti A et.al. (2020). ELF4 Is a Target of miR-124 and Promotes Neuroblastoma Proliferation and Undifferentiated State. Mol Cancer Res 18:68-78.
1186Cai L et.al. (2020). The let-7c/HoxB7 axis regulates the cell proliferation, migration and apoptosis in hepatocellular carcinoma. Anticancer Drugs 31:6-18.
1185Hwang JH et.al. (2020). A mutant KRAS-induced factor REG4 promotes cancer stem cell properties via Wnt/beta-catenin signaling. Int J Cancer 146:2877-2890.
1184Veschi V et.al. (2020). Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant. Oncogene 39:987-1003.
1183Record J et.al. (2020). An intronic deletion in megakaryoblastic leukemia 1 is associated with hyperproliferation of B cells in triplets with Hodgkin lymphoma. Haematologica 105:1339-1350.
1182Mason B et.al. (2020). Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation. Cell Mol Life Sci 77:2605-2620.
1181Chi J et.al. (2020). AGR3 promotes the stemness of colorectal cancer via modulating Wnt/beta-catenin signalling. Cell Signal 65:109419.
1180Meel MH et.al. (2020). MEK/MELK inhibition and blood-brain barrier deficiencies in atypical teratoid/rhabdoid tumors. Neuro Oncol 22:58-69.
1179Adamus A et.al. (2020). SGPL1321 mutation: one main trigger for invasiveness of pediatric alveolar rhabdomyosarcoma. Cancer Gene Ther 27:571-584.
1178Somers K et.al. (2020). Potent antileukemic activity of curaxin CBL0137 against MLL-rearranged leukemia. Int J Cancer 146:1902-1916.
1177Grasso S et.al. (2020). The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma. Cell Death Differ 27:790-807.
1176Wang L et.al. (2020). ATF3 promotes erastin-induced ferroptosis by suppressing system Xc(.) Cell Death Differ 27:662-675.
1175Tsvankin V et.al. (2020). ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma. Neurosurgery 86:742-751.
1174Saha SK et.al. (2020). PROM1 and PROM2 expression differentially modulates clinical prognosis of cancer: a multiomics analysis. Cancer Gene Ther 27:147-167.
1173Fan Y et.al. (2020). Expression profile and bioinformatics analysis of COMMD10 in BALB/C mice and human. Cancer Gene Ther 27:216-225.
2019 (n=314)
1172van Wezel EM et.al. (2019). Mesenchymal Neuroblastoma Cells Are Undetected by Current mRNA Marker Panels: The Development of a Specific Neuroblastoma Mesenchymal Minimal Residual Disease Panel. JCO Precis Oncol 3:.
1171Chaib I et.al. (2019). Osimertinib and dihydroartemisinin: a novel drug combination targeting head and neck squamous cell carcinoma. Ann Transl Med 7:651.
1170Guo S et.al. (2019). Novel Breast-Specific Long Non-coding RNA LINC00993 Acts as a Tumor Suppressor in Triple-Negative Breast Cancer. Front Oncol 9:1325.
1169Prajapati B et.al. (2019). Identification of lncRNAs Associated With Neuroblastoma in Cross-Sectional Databases: Potential Biomarkers. Front Mol Neurosci 12:293.
1168Wang K et.al. (2019). Long Non-Coding RNA LINC00511 Mediates the Effects of ESR1 on Proliferation and Invasion of Ovarian Cancer Through miR-424-5p and miR-370-5p. Cancer Manag Res 11:10807-10819.
1167Xu Z et.al. (2019). Demethylation and Overexpression of CSF2 are Involved in Immune Response, Chemotherapy Resistance, and Poor Prognosis in Colorectal Cancer. Onco Targets Ther 12:11255-11269.
1166Yang L et.al. (2019). Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer. Clin Epigenetics 11:199.
1165Wang X et.al. (2019). Downregulated SPINK4 is associated with poor survival in colorectal cancer. BMC Cancer 19:1258.
1164Dyberg C et.al. (2019). Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth. Cancers (Basel) 12:.
1163Salcher S et.al. (2019). Repaglinide Silences the FOXO3/Lumican Axis and Represses the Associated Metastatic Potential of Neuronal Cancer Cells. Cells 9:.
1162Pai S et.al. (2019). CD47-SIRPalpha Signaling Induces Epithelial-Mesenchymal Transition and Cancer Stemness and Links to a Poor Prognosis in Patients with Oral Squamous Cell Carcinoma. Cells 8:.
1161Ding Y et.al. (2019). MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2. J Exp Clin Cancer Res 38:498.
1160Tranchevent LC et.al. (2019). A deep neural network approach to predicting clinical outcomes of neuroblastoma patients. BMC Med Genomics 12:178.
1159Slomp A et.al. (2019). Multiple myeloma with 1q21 amplification is highly sensitive to MCL-1 targeting. Blood Adv 3:4202-4214.
1158Zhong X et.al. (2019). Cellular components in tumor microenvironment of neuroblastoma and the prognostic value. PeerJ 7:e8017.
1157Nguyen HD et.al. (2019). The alpha9 Nicotinic Acetylcholine Receptor Mediates Nicotine-Induced PD-L1 Expression and Regulates Melanoma Cell Proliferation and Migration. Cancers (Basel) 11:.
1156Neve A et.al. (2019). Crosstalk between SHH and FGFR Signaling Pathways Controls Tissue Invasion in Medulloblastoma. Cancers (Basel) 11:.
1155Almutairi B et.al. (2019). Epigenetic deregulation of GATA3 in neuroblastoma is associated with increased GATA3 protein expression and with poor outcomes. Sci Rep 9:18934.
1154Zhang S et.al. (2019). N-myc downstream-regulated gene 1 inhibits the proliferation of colorectal cancer through emulative antagonizing NEDD4-mediated ubiquitylation of p21. J Exp Clin Cancer Res 38:490.
1153Luo Y et.al. (2019). miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells. J Exp Clin Cancer Res 38:488.
1152Dudzik P et.al. (2019). Aberrant promoter methylation may be responsible for the control of CD146 (MCAM) gene expression during breast cancer progression. Acta Biochim Pol 66:619-625.
1151Xu Y et.al. (2019). TRIM proteins in neuroblastoma. Biosci Rep 39:.
1150Wang L et.al. (2019). ASCL1 is a MYCN Nat Commun 10:5622.
1149Richter AM et.al. (2019). RASSF10 Is a TGFbeta-Target That Regulates ASPP2 and E-Cadherin Expression and Acts as Tumor Suppressor That Is Epigenetically Downregulated in Advanced Cancer. Cancers (Basel) 11:.
1148Dong W et.al. (2019). CARF, As An Oncogene, Promotes Colorectal Cancer Stemness By Activating ERBB Signaling Pathway. Onco Targets Ther 12:9041-9051.
1147Lambo S et.al. (2019). The molecular landscape of ETMR at diagnosis and relapse. Nature 576:274-280.
1146Deutschmeyer V et.al. (2019). Epigenetic therapy of novel tumour suppressor ZAR1 and its cancer biomarker function. Clin Epigenetics 11:182.
1145He Y et.al. (2019). Clinical and transcriptional signatures of human CD204 reveal an applicable marker for the protumor phenotype of tumor-associated macrophages in breast cancer. Aging (Albany NY) 11:10883-10901.
1144Wu S et.al. (2019). Silencing expression of PHF14 in glioblastoma promotes apoptosis, mitigates proliferation and invasiveness via Wnt signal pathway. Cancer Cell Int 19:314.
1143Boloix A et.al. (2019). Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer. Front Oncol 9:1173.
1142Trigg RM et.al. (2019). The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status. Nat Commun 10:5428.
1141Yuan F et.al. (2019). Identification of Key Pathways and Genes in the Orai2 Mediated Classical and Mesenchymal Subtype of Glioblastoma by Bioinformatic Analyses. Dis Markers 2019:7049294.
1140Yari H et.al. (2019). LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription. Nat Commun 10:5334.
1139Treisman DM et.al. (2019). Sox2(+) cells in Sonic Hedgehog-subtype medulloblastoma resist p53-mediated cell-cycle arrest response and drive therapy-induced recurrence. Neurooncol Adv 1:vdz027.
1138Trojan SE et.al. (2019). The influence of PFK-II overexpression on neuroblastoma patients survival may be dependent on the particular isoenzyme expressed, PFKFB3 or PFKFB4. Cancer Cell Int 19:292.
1137Cancer M et.al. (2019). BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells. Cell Death Dis 10:881.
1136Zhang G et.al. (2019). TRIP13 promotes the cell proliferation, migration and invasion of glioblastoma through the FBXW7/c-MYC axis. Br J Cancer 121:1069-1078.
1135Li C et.al. (2019). Low Expression of 14-3-3beta Is Associated With Adverse Survival of Diffuse Large B-Cell Lymphoma Patients. Front Med (Lausanne) 6:237.
1134Metselaar DS et.al. (2019). Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin. EBioMedicine 50:81-92.
1133Gil M et.al. (2019). Interleukin-18 Is a Prognostic Biomarker Correlated with CD8(+) T Cell and Natural Killer Cell Infiltration in Skin Cutaneous Melanoma. J Clin Med 8:.
1132Song H et.al. (2019). LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p. Aging (Albany NY) 11:9794-9810.
1131Wang Q et.al. (2019). The Histone Demethylase NO66 Induces Glioma Cell Proliferation. Anticancer Res 39:6007-6014.
1130Chaturvedi NK et.al. (2019). Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma. BMC Cancer 19:1056.
1129Dong Z et.al. (2019). MYST1/KAT8 contributes to tumor progression by activating EGFR signaling in glioblastoma cells. Cancer Med 8:7793-7808.
1128Liu PY et.al. (2019). The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35. Nat Commun 10:5026.
1127Vega FM et.al. (2019). CD44-high neural crest stem-like cells are associated with tumour aggressiveness and poor survival in neuroblastoma tumours. EBioMedicine 49:82-95.
1126Su J et.al. (2019). LCTL Is a Prognostic Biomarker and Correlates With Stromal and Immune Infiltration in Gliomas. Front Oncol 9:1083.
1125Lebedev TD et.al. (2019). Two Receptors, Two Isoforms, Two Cancers: Comprehensive Analysis of KIT and TrkA Expression in Neuroblastoma and Acute Myeloid Leukemia. Front Oncol 9:1046.
1124Shangguan W et.al. (2019). FoxD2-AS1 is a prognostic factor in glioma and promotes temozolomide resistance in a O(6)-methylguanine-DNA methyltransferase-dependent manner. Korean J Physiol Pharmacol 23:475-482.
1123Oliynyk G et.al. (2019). MYCN-enhanced Oxidative and Glycolytic Metabolism Reveals Vulnerabilities for Targeting Neuroblastoma. iScience 21:188-204.
1122El-Naggar AM et.al. (2019). Class I HDAC inhibitors enhance YB-1 acetylation and oxidative stress to block sarcoma metastasis. EMBO Rep 20:e48375.
1121Fang Y et.al. (2019). Spica Prunellae Extract Enhances Fluorouracil Sensitivity of 5-Fluorouracil-Resistant Human Colon Carcinoma HCT-8/5-FU Cells via TOP2alpha and miR-494. Biomed Res Int 2019:5953619.
1120Wang Y et.al. (2019). Integrated analysis of transcriptome-wide m(6)A methylome of osteosarcoma stem cells enriched by chemotherapy. Epigenomics 11:1693-1715.
1119Yin C et.al. (2019). G9a promotes cell proliferation and suppresses autophagy in gastric cancer by directly activating mTOR. FASEB J 33:14036-14050.
1118Smirnov A et.al. (2019). Transglutaminase 3 is expressed in basal cell carcinoma of the skin. Eur J Dermatol 29:477-483.
1117Kostopoulou ON et.al. (2019). Analyses of FGFR3 and PIK3CA mutations in neuroblastomas and the effects of the corresponding inhibitors on neuroblastoma cell lines. Int J Oncol 55:1372-1384.
1116Wang R et.al. (2019). Histone methyltransferase SUV39H2 regulates cell growth and chemosensitivity in glioma via regulation of hedgehog signaling. Cancer Cell Int 19:269.
1115Xu Y et.al. (2019). Overexpression of Rad51 predicts poor prognosis and silencing of Rad51 increases chemo-sensitivity to doxorubicin in neuroblastoma. Am J Transl Res 11:5788-5799.
1114Gu J et.al. (2019). PTPRU, As A Tumor Suppressor, Inhibits Cancer Stemness By Attenuating Hippo/YAP Signaling Pathway. Onco Targets Ther 12:8095-8104.
1113Cheung CHY et.al. (2019). Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy. Cell Death Dis 10:786.
1112Frisira E et.al. (2019). NPI-0052 and gamma-radiation induce a synergistic apoptotic effect in medulloblastoma. Cell Death Dis 10:785.
1111Passariello A et.al. (2019). PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas. Cancers (Basel) 11:.
1110Li J et.al. (2019). AGR2 is controlled by DNMT3a-centered signaling module and mediates tumor resistance to 5-Aza in colorectal cancer. Exp Cell Res 385:111644.
1109Tong L et.al. (2019). CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma. Cancer Gene Ther :.
1108Kaesler S et.al. (2019). Targeting tumor-resident mast cells for effective anti-melanoma immune responses. JCI Insight 4:.
1107Zhu J et.al. (2019). Engrailed 1 overexpression as a potential prognostic marker in Lower Grade Glioma. PeerJ 7:e7414.
1106Fekry B et.al. (2019). HNF4alpha-Deficient Fatty Liver Provides a Permissive Environment for Sex-Independent Hepatocellular Carcinoma. Cancer Res 79:5860-5873.
1105Mazzocchi M et.al. (2019). Gene Co-expression Analysis Identifies Histone Deacetylase 5 and 9 Expression in Midbrain Dopamine Neurons and as Regulators of Neurite Growth via Bone Morphogenetic Protein Signaling. Front Cell Dev Biol 7:191.
1104Lin DD et.al. (2019). Upregulation of OTUD7B (Cezanne) Promotes Tumor Progression via AKT/VEGF Pathway in Lung Squamous Carcinoma and Adenocarcinoma. Front Oncol 9:862.
1103Zhang X et.al. (2019). TRIB3 promotes lung cancer progression by activating beta-catenin signaling. Eur J Pharmacol 863:172697.
1102Hsieh CH et.al. (2019). Quantitative Proteomics of Th-MYCN Transgenic Mice Reveals Aurora Kinase Inhibitor Altered Metabolic Pathways and Enhanced ACADM To Suppress Neuroblastoma Progression. J Proteome Res 18:3850-3866.
1101Scicchitano S et.al. (2019). The stem cell-associated transcription co-factor, ZNF521, interacts with GLI1 and GLI2 and enhances the activity of the Sonic hedgehog pathway. Cell Death Dis 10:715.
1100Ognibene M et.al. (2019). Role of GOLPH3 and TPX2 in Neuroblastoma DNA Damage Response and Cell Resistance to Chemotherapy. Int J Mol Sci 20:.
1099Pathania AS et.al. (2019). GRK2 promotes growth of medulloblastoma cells and protects them from chemotherapy-induced apoptosis. Sci Rep 9:13902.
1098Wang J et.al. (2019). NT5E/CD73 as Correlative Factor of Patient Survival and Natural Killer Cell Infiltration in Glioblastoma. J Clin Med 8:.
1097Robinson MH et.al. (2019). Upregulation of the chromatin remodeler HELLS is mediated by YAP1 in Sonic Hedgehog Medulloblastoma. Sci Rep 9:13611.
1096Senfter D et.al. (2019). High impact of miRNA-4521 on FOXM1 expression in medulloblastoma. Cell Death Dis 10:696.
1095Wang J et.al. (2019). The association between lncRNA LINC01296 and the clinical characteristics in neuroblastoma. J Pediatr Surg 54:2589-2594.
1094Cui J et.al. (2019). Inorganic Selenium Induces Nonapoptotic Programmed Cell Death in PC-3 Prostate Cancer Cells Associated with Inhibition of Glycolysis. J Agric Food Chem 67:10637-10645.
1093Liu N et.al. (2019). SNRPB promotes the tumorigenic potential of NSCLC in part by regulating RAB26. Cell Death Dis 10:667.
1092Park SY et.al. (2019). The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance. J Exp Clin Cancer Res 38:399.
1091Horn S et.al. (2019). De novo variants in PAK1 lead to intellectual disability with macrocephaly and seizures. Brain 142:3351-3359.
1090Koach J et.al. (2019). Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface. Cancer Res 79:5652-5667.
1089Feng S et.al. (2019). LncRNA-CTS promotes metastasis and epithelial-to-mesenchymal transition through regulating miR-505/ZEB2 axis in cervical cancer. Cancer Lett 465:105-117.
1088Qiao J et.al. (2019). Identification of alpha-N-catenin as a novel tumor suppressor in neuroblastoma. Oncotarget 10:5028-5040.
1087Hua Q et.al. (2019). LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis. J Hematol Oncol 12:91.
1086Schonkeren SL et.al. (2019). Nervous NDRGs: the N-myc downstream-regulated gene family in the central and peripheral nervous system. Neurogenetics 20:173-186.
1085Hu C et.al. (2019). ROCK1 promotes migration and invasion of nonsmallcell lung cancer cells through the PTEN/PI3K/FAK pathway. Int J Oncol 55:833-844.
1084Zhang L et.al. (2019). Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Cancer Cell 36:302-318.e7.
1083Matsumoto S et.al. (2019). GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFbeta signaling. Nat Commun 10:3882.
1082Guo P et.al. (2019). Therapeutic genome editing of triple-negative breast tumors using a noncationic and deformable nanolipogel. Proc Natl Acad Sci U S A 116:18295-18303.
1081Alptekin A et.al. (2019). Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity. Oncogene 38:7504-7520.
1080Li J et.al. (2019). Down-Regulation of Phosphoribosyl Pyrophosphate Synthetase 1 Inhibits Neuroblastoma Cell Proliferation. Cells 8:.
1079Wu PY et.al. (2019). Activation of Aryl Hydrocarbon Receptor by Kynurenine Impairs Progression and Metastasis of Neuroblastoma. Cancer Res 79:5550-5562.
1078Suenaga Y et.al. (2019). TAp63 represses transcription of MYCN/NCYM gene and its high levels of expression are associated with favorable outcome in neuroblastoma. Biochem Biophys Res Commun 518:311-318.
1077Cheng N et.al. (2019). Transcription factor Six2 induces a stem cell-like phenotype in renal cell carcinoma cells. FEBS Open Bio 9:1808-1816.
1076Sun M et.al. (2019). Targeting the Chromosomal Passenger Complex Subunit INCENP Induces Polyploidization, Apoptosis, and Senescence in Neuroblastoma. Cancer Res 79:4937-4950.
1075Chen JJ et.al. (2019). MRP4 sustains Wnt/beta-catenin signaling for pregnancy, endometriosis and endometrial cancer. Theranostics 9:5049-5064.
1074Somasundaram DB et.al. (2019). De novo regulation of RD3 synthesis in residual neuroblastoma cells after intensive multi-modal clinical therapy harmonizes disease evolution. Sci Rep 9:11766.
1073Nitta RT et.al. (2019). Casein kinase 2 inhibition sensitizes medulloblastoma to temozolomide. Oncogene 38:6867-6879.
1072Yogev O et.al. (2019). In Vivo Modeling of Chemoresistant Neuroblastoma Provides New Insights into Chemorefractory Disease and Metastasis. Cancer Res 79:5382-5393.
1071Ravi A et.al. (2019). Rhinovirus-16 induced temporal interferon responses in nasal epithelium links with viral clearance and symptoms. Clin Exp Allergy 49:1587-1597.
1070Debruyne DN et.al. (2019). BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells. Nature 572:676-680.
1069Purvis IJ et.al. (2019). Role of MYC-miR-29-B7-H3 in Medulloblastoma Growth and Angiogenesis. J Clin Med 8:.
1068Zong Z et.al. (2019). M1 Macrophages Induce PD-L1 Expression in Hepatocellular Carcinoma Cells Through IL-1beta Signaling. Front Immunol 10:1643.
1067Wagner M et.al. (2019). Blockade of Lymphangiogenesis Shapes Tumor-Promoting Adipose Tissue Inflammation. Am J Pathol 189:2102-2114.
1066Aravindan S et.al. (2019). Targeting acquired oncogenic burden in resilient pancreatic cancer: a novel benefit from marine polyphenols. Mol Cell Biochem 460:175-193.
1065Wellenstein MD et.al. (2019). Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis. Nature 572:538-542.
1064Bui CB et.al. (2019). ARID1A-SIN3A drives retinoic acid-induced neuroblastoma differentiation by transcriptional repression of TERT. Mol Carcinog 58:1998-2007.
1063Lu J et.al. (2019). Transcription factor CEBPB inhibits the proliferation of osteosarcoma by regulating downstream target gene CLEC5A. J Clin Lab Anal 33:e22985.
1062Mu X et.al. (2019). Linc00961 inhibits the proliferation and invasion of skin melanoma by targeting the miR367/PTEN axis. Int J Oncol 55:708-720.
1061Ando K et.al. (2019). Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells. Int J Mol Sci 20:.
1060Yi GZ et.al. (2019). Acquired temozolomide resistance in MGMT-deficient glioblastoma cells is associated with regulation of DNA repair by DHC2. Brain 142:2352-2366.
1059Wong M et.al. (2019). JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma. Nat Commun 10:3319.
1058Kanemaru Y et.al. (2019). Dramatic response of BRAF V600E-mutant epithelioid glioblastoma to combination therapy with BRAF and MEK inhibitor: establishment and xenograft of a cell line to predict clinical efficacy. Acta Neuropathol Commun 7:119.
1057Javanmardi N et.al. (2019). Analysis of ALK, MYCN, and the ALK ligand ALKAL2 (FAM150B/AUGalpha) in neuroblastoma patient samples with chromosome arm 2p rearrangements. Genes Chromosomes Cancer :.
1056Huang C et.al. (2019). FoxM1 Induced Paclitaxel Resistance via Activation of the FoxM1/PHB1/RAF-MEK-ERK Pathway and Enhancement of the ABCA2 Transporter. Mol Ther Oncolytics 14:196-212.
1055Morabito M et.al. (2019). An autocrine ActivinB mechanism drives TGFbeta/Activin signaling in Group 3 medulloblastoma. EMBO Mol Med 11:e9830.
1054Guo Q et.al. (2019). NAMPT: A potential prognostic and therapeutic biomarker in patients with glioblastoma. Oncol Rep 42:963-972.
1053Bishayee K et.al. (2019). Targeting the Difficult-to-Drug CD71 and MYCN with Gambogic Acid and Vorinostat in a Class of Neuroblastomas. Cell Physiol Biochem 53:258-280.
1052Mohlin S et.al. (2019). Anti-tumor effects of PIM/PI3K/mTOR triple kinase inhibitor IBL-302 in neuroblastoma. EMBO Mol Med 11:e10058.
1051Lange I et.al. (2019). Calcium signaling regulates fundamental processes involved in Neuroblastoma progression. Cell Calcium 82:102052.
1050Rusu P et.al. (2019). GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile. Cell Stem Cell 25:241-257.e8.
1049Gana CC et.al. (2019). MRP1 modulators synergize with buthionine sulfoximine to exploit collateral sensitivity and selectively kill MRP1-expressing cancer cells. Biochem Pharmacol 168:237-248.
1048Jones DTW et.al. (2019). Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours. Nat Rev Cancer 19:420-438.
1047Chen Q et.al. (2019). Screening and identification of hub genes in pancreatic cancer by integrated bioinformatics analysis. J Cell Biochem 120:19496-19508.
1046Raman P et.al. (2019). A comparison of survival analysis methods for cancer gene expression RNA-Sequencing data. Cancer Genet 235-236:1-12.
1045Cao M et.al. (2019). Identification of age Neurobiol Aging 81:116-126.
1044Gambale A et.al. (2019). Germline mutations and new copy number variants among 40 pediatric cancer patients suspected for genetic predisposition. Clin Genet 96:359-365.
1043Czystowska-Kuzmicz M et.al. (2019). Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma. Nat Commun 10:3000.
1042Berney E et.al. (2019). The SR-B1 Receptor as a Potential Target for Treating Glioblastoma. J Oncol 2019:1805841.
1041Bernink JH et.al. (2019). c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies. Nat Immunol 20:992-1003.
1040El Hassouni B et.al. (2019). Uridine Cytidine Kinase 2 as a Potential Biomarker for Treatment with RX-3117 in Pancreatic Cancer. Anticancer Res 39:3609-3614.
1039Roca MS et.al. (2019). Implication for Cancer Stem Cells in Solid Cancer Chemo-Resistance: Promising Therapeutic Strategies Based on the Use of HDAC Inhibitors. J Clin Med 8:.
1038Romani M et.al. (2019). Targeting of Histone Demethylases KDM5A and KDM6B Inhibits the Proliferation of Temozolomide-Resistant Glioblastoma Cells. Cancers (Basel) 11:.
1037Chai Y et.al. (2019). MPC1 deletion is associated with poor prognosis and temozolomide resistance in glioblastoma. J Neurooncol 144:293-301.
1036Civita P et.al. (2019). Laser Capture Microdissection and RNA-Seq Analysis: High Sensitivity Approaches to Explain Histopathological Heterogeneity in Human Glioblastoma FFPE Archived Tissues. Front Oncol 9:482.
1035Tarone L et.al. (2019). Naturally occurring cancers in pet dogs as pre-clinical models for cancer immunotherapy. Cancer Immunol Immunother 68:1839-1853.
1034Riccardo F et.al. (2019). Identification of CSPG4 as a promising target for translational combinatorial approaches in osteosarcoma. Ther Adv Med Oncol 11:1758835919855491.
1033Koncar RF et.al. (2019). Identification of Novel RAS Signaling Therapeutic Vulnerabilities in Diffuse Intrinsic Pontine Gliomas. Cancer Res 79:4026-4041.
1032Li K et.al. (2019). TROAP Promotes Breast Cancer Proliferation and Metastasis. Biomed Res Int 2019:6140951.
1031Mather RL et.al. (2019). Human Sialic acid O-acetyl esterase (SIAE) Sci Rep 9:8609.
1030Lin J et.al. (2019). eIF6 Promotes Colorectal Cancer Proliferation and Invasion by Regulating AKT-Related Signaling Pathways. J Biomed Nanotechnol 15:1556-1567.
1029Russo R et.al. (2019). Characterization of Two Cases of Congenital Dyserythropoietic Anemia Type I Shed Light on the Uncharacterized C15orf41 Protein. Front Physiol 10:621.
1028Piro G et.al. (2019). Vorinostat Potentiates 5-Fluorouracil/Cisplatin Combination by Inhibiting Chemotherapy-Induced EGFR Nuclear Translocation and Increasing Cisplatin Uptake. Mol Cancer Ther 18:1405-1417.
1027Pang Y et.al. (2019). TP53BP2 decreases cell proliferation and induces autophagy in neuroblastoma cell lines. Oncol Lett 17:4976-4984.
1026Xie R et.al. (2019). ANXA2 Silencing Inhibits Proliferation, Invasion, and Migration in Gastric Cancer Cells. J Oncol 2019:4035460.
1025Kampen KR et.al. (2019). Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells. Nat Commun 10:2542.
1024Hirano T et.al. (2019). Forced expression of NR4A3 induced the differentiation of human neuroblastoma-derived NB1 cells. Med Oncol 36:66.
1023Ye C et.al. (2019). Overexpression of FZD7 is associated with poor survival in patients with colon cancer. Pathol Res Pract 215:152478.
1022Maximov V et.al. (2019). Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma. Nat Commun 10:2410.
1021Munoz-Galvan S et.al. (2019). New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools. J Exp Clin Cancer Res 38:234.
1020Gong D et.al. (2019). The m(6)A-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca(2+) influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway. J Exp Clin Cancer Res 38:233.
1019Folkerts H et.al. (2019). Elevated VMP1 expression in acute myeloid leukemia amplifies autophagy and is protective against venetoclax-induced apoptosis. Cell Death Dis 10:421.
1018Nam J et.al. (2019). Disruption of the Myc-PDE4B regulatory circuitry impairs B-cell lymphoma survival. Leukemia 33:2912-2923.
1017Kim KS et.al. (2019). miR551b Regulates Colorectal Cancer Progression by Targeting the ZEB1 Signaling Axis. Cancers (Basel) 11:.
1016Zheng BN et.al. (2019). Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4alpha. Theranostics 9:2606-2617.
1015Lee YK et.al. (2019). Promotion of Cell Death in Cisplatin-Resistant Ovarian Cancer Cells through KDM1B-DCLRE1B Modulation. Int J Mol Sci 20:.
1014Zhao GS et.al. (2019). High expression of ID1 facilitates metastasis in human osteosarcoma by regulating the sensitivity of anoikis via PI3K/AKT depended suppression of the intrinsic apoptotic signaling pathway. Am J Transl Res 11:2117-2139.
1013Li H et.al. (2019). Small molecule inhibitor agerafenib effectively suppresses neuroblastoma tumor growth in mouse models via inhibiting ERK MAPK signaling. Cancer Lett 457:129-141.
1012Zhu R et.al. (2019). miR-23b-3p suppressing PGC1alpha promotes proliferation through reprogramming metabolism in osteosarcoma. Cell Death Dis 10:381.
1011Xia Y et.al. (2019). Metabolic Reprogramming by MYCN Confers Dependence on the Serine-Glycine-One-Carbon Biosynthetic Pathway. Cancer Res 79:3837-3850.
1010Varon M et.al. (2019). The long noncoding RNA TP73-AS1 promotes tumorigenicity of medulloblastoma cells. Int J Cancer 145:3402-3413.
1009Cho A et.al. (2019). An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2. Mol Ther 27:1286-1298.
1008Palombo R et.al. (2019). The Promoter-Associated Noncoding RNA pncCCND1_B Assembles a Protein-RNA Complex to Regulate Cyclin D1 Transcription in Ewing Sarcoma. Cancer Res 79:3570-3582.
1007Firuzi O et.al. (2019). Role of c-MET Inhibitors in Overcoming Drug Resistance in Spheroid Models of Primary Human Pancreatic Cancer and Stellate Cells. Cancers (Basel) 11:.
1006Huang Z et.al. (2019). miR-340-FHL2 axis inhibits cell growth and metastasis in ovarian cancer. Cell Death Dis 10:372.
1005Caggiano C et.al. (2019). c-MYC empowers transcription and productive splicing of the oncogenic splicing factor Sam68 in cancer. Nucleic Acids Res 47:6160-6171.
1004Felipe-Abrio B et.al. (2019). c-MYB Mol Oncol 13:1519-1533.
1003Lehrer S et.al. (2019). von Willebrand Factor Gene Expression in Primary Lower Grade Glioma: Mutually Co-Occurring Mutations in von Willebrand Factor, ATRX, and TP53. Brain Tumor Res Treat 7:33-38.
1002Georgescu C et.al. (2019). A TMEFF2-regulated cell cycle derived gene signature is prognostic of recurrence risk in prostate cancer. BMC Cancer 19:423.
1001Cao H et.al. (2019). High FOXK1 expression correlates with poor outcomes in hepatocellular carcinoma and regulates stemness of hepatocellular carcinoma cells. Life Sci 228:128-134.
1000Szemes M et.al. (2019). Wnt Signaling Is a Major Determinant of Neuroblastoma Cell Lineages. Front Mol Neurosci 12:90.
999Koster J et.al. (2019). A library of Neo Open Reading Frame peptides (NOPs) as a sustainable resource of common neoantigens in up to 50% of cancer patients. Sci Rep 9:6577.
998Li X et.al. (2019). Prognostic significance of LAPTM4B and p27kip1 expression in triple-negative breast cancer. Cancer Biomark 25:19-27.
997Zhang Q et.al. (2019). ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa/VEGFR2/ERK pathway. J Exp Clin Cancer Res 38:173.
996Pfaff E et.al. (2019). Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience. Eur J Cancer 114:27-35.
995Kim JH et.al. (2019). SON haploinsufficiency causes impaired pre-mRNA splicing of CAKUT genes and heterogeneous renal phenotypes. Kidney Int 95:1494-1504.
994Dong Z et.al. (2019). Transcriptional activation of SIRT6 via FKHRL1/FOXO3a inhibits the Warburg effect in glioblastoma cells. Cell Signal 60:100-113.
993Lim JKM et.al. (2019). Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance. Proc Natl Acad Sci U S A 116:9433-9442.
992Goulding SR et.al. (2019). Gene co-expression analysis of the human substantia nigra identifies BMP2 as a neurotrophic factor that can promote neurite growth in cells overexpressing wild-type or A53T alpha-synuclein. Parkinsonism Relat Disord 64:194-201.
991Sun L et.al. (2019). Resolvin D1 prevents epithelial-mesenchymal transition and reduces the stemness features of hepatocellular carcinoma by inhibiting paracrine of cancer-associated fibroblast-derived COMP. J Exp Clin Cancer Res 38:170.
990MacArthur IC et.al. (2019). Prohibitin promotes de-differentiation and is a potential therapeutic target in neuroblastoma. JCI Insight 5:.
989Hu W et.al. (2019). NAV2 facilitates invasion of cutaneous melanoma cells by targeting SNAI2 through the GSK-3beta/beta-catenin pathway. Arch Dermatol Res 311:399-410.
988Guo P et.al. (2019). ITGA2 as a potential nanotherapeutic target for glioblastoma. Sci Rep 9:6195.
987Saha SK et.al. (2019). Systematic Multiomics Analysis of Alterations in C1QBP mRNA Expression and Relevance for Clinical Outcomes in Cancers. J Clin Med 8:.
986Abruzzese MP et.al. (2019). The homeobox transcription factor MEIS2 is a regulator of cancer cell survival and IMiDs activity in Multiple Myeloma: modulation by Bromodomain and Extra-Terminal (BET) protein inhibitors. Cell Death Dis 10:324.
985Lee NH et.al. (2019). SERPINB2 Is a Novel Indicator of Cancer Stem Cell Tumorigenicity in Multiple Cancer Types. Cancers (Basel) 11:.
984Diviney A et.al. (2019). An age-based, RNA expression paradigm for survival biomarker identification for pediatric neuroblastoma and acute lymphoblastic leukemia. Cancer Cell Int 19:73.
983Yu Y et.al. (2019). Inhibition of Ubiquitin-Specific Protease 14 Suppresses Cell Proliferation and Synergizes with Chemotherapeutic Agents in Neuroblastoma. Mol Cancer Ther 18:1045-1056.
982Park SR et.al. (2019). A Novel Endogenous Damage Signal, CSF-2, Activates Multiple Beneficial Functions of Adipose Tissue-Derived Mesenchymal Stem Cells. Mol Ther 27:1087-1100.
981Savci-Heijink CD et.al. (2019). A specific gene expression signature for visceral organ metastasis in breast cancer. BMC Cancer 19:333.
980Yeh YC et.al. (2019). Dichotomy of the function of DDR1 in cells and disease progression. Biochim Biophys Acta Mol Cell Res 1866:118473.
979van Groningen T et.al. (2019). A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma. Nat Commun 10:1530.
978Cowman S et.al. (2019). Decrease of Nibrin expression in chronic hypoxia is associated with hypoxia-induced chemoresistance in some brain tumour cells. BMC Cancer 19:300.
977Zhang YX et.al. (2019). Nanoenabled Modulation of Acidic Tumor Microenvironment Reverses Anergy of Infiltrating T Cells and Potentiates Anti-PD-1 Therapy. Nano Lett 19:2774-2783.
976Huang K et.al. (2019). Bioinformatics analysis of the prognostic value of CCT6A and associated signalling pathways in breast cancer. Mol Med Rep 19:4344-4352.
975Sahin I et.al. (2019). Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma. Blood Adv 3:995-1002.
974Zhang K et.al. (2019). High KCNQ1OT1 expression might independently predict shorter survival of colon adenocarcinoma. Future Oncol 15:1085-1095.
973Sun T et.al. (2019). Anoikis resistant mediated by FASN promoted growth and metastasis of osteosarcoma. Cell Death Dis 10:298.
972Chai Y et.al. (2019). Prognostic Role of Chicken Ovalbumin Upstream Promoter Transcription Factor II in Isocitrate Dehydrogenase-Mutant Glioma with 1p19q Co-Deletion. J Mol Neurosci 68:234-242.
971Lu L et.al. (2019). Inhibition of the STAT3 target SGK1 sensitizes diffuse large B cell lymphoma cells to AKT inhibitors. Blood Cancer J 9:43.
970Hubner JM et.al. (2019). EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma. Neuro Oncol 21:878-889.
969Maggio V et.al. (2019). A novel DNA-binding motif in prostate tumor overexpressed-1 (PTOV1) required for the expression of ALDH1A1 and CCNG2 in cancer cells. Cancer Lett 452:158-167.
968Niu Y et.al. (2019). RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3. Mol Cancer 18:46.
967Karpus ON et.al. (2019). Colonic CD90+ Crypt Fibroblasts Secrete Semaphorins to Support Epithelial Growth. Cell Rep 26:3698-3708.e5.
966Luo H et.al. (2019). WP1130 reveals USP24 as a novel target in T-cell acute lymphoblastic leukemia. Cancer Cell Int 19:56.
965Guo P et.al. (2019). Dual complementary liposomes inhibit triple-negative breast tumor progression and metastasis. Sci Adv 5:eaav5010.
964Otsuka K et.al. (2019). Combining peptide TNIIIA2 with all-trans retinoic acid accelerates N-Myc protein degradation and neuronal differentiation in MYCN-amplified neuroblastoma cells. Am J Cancer Res 9:434-448.
963Herold S et.al. (2019). Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase. Nature 567:545-549.
962Zhang R et.al. (2019). Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer. Cell Death Dis 10:273.
961Bhatia S et.al. (2019). Inhibition of EphB4-Ephrin-B2 Signaling Reprograms the Tumor Immune Microenvironment in Head and Neck Cancers. Cancer Res 79:2722-2735.
960Wu Y et.al. (2019). ITGA6 and RPSA synergistically promote pancreatic cancer invasion and metastasis via PI3K and MAPK signaling pathways. Exp Cell Res 379:30-47.
959Hoffman M et.al. (2019). Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma. Cancer Res 79:2111-2123.
958Saha SK et.al. (2019). Multiomics Analysis Reveals that GLS and GLS2 Differentially Modulate the Clinical Outcomes of Cancer. J Clin Med 8:.
957Rodrigo MAM et.al. (2019). Transcriptomic Landscape of Cisplatin-Resistant Neuroblastoma Cells. Cells 8:.
956Chen J et.al. (2019). SLC34A2 promotes neuroblastoma cell stemness via enhancement of miR-25/Gsk3beta-mediated activation of Wnt/beta-catenin signaling. FEBS Open Bio 9:527-537.
955Mazor G et.al. (2019). The lncRNA TP73-AS1 is linked to aggressiveness in glioblastoma and promotes temozolomide resistance in glioblastoma cancer stem cells. Cell Death Dis 10:246.
954Khalid M et.al. (2019). Gene Regulation by Antitumor miR-204-5p in Pancreatic Ductal Adenocarcinoma: The Clinical Significance of Direct RACGAP1 Regulation. Cancers (Basel) 11:.
953Shen A et.al. (2019). EBF1-Mediated Upregulation of Ribosome Assembly Factor PNO1 Contributes to Cancer Progression by Negatively Regulating the p53 Signaling Pathway. Cancer Res 79:2257-2270.
952Jolly MK et.al. (2019). E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms. Mol Cancer Res 17:1391-1402.
951Wang X et.al. (2019). Hypermethylated and downregulated MEIS2 are involved in stemness properties and oxaliplatin-based chemotherapy resistance of colorectal cancer. J Cell Physiol 234:18180-18191.
950Han X et.al. (2019). Tripartite motif-containing 15 overexpression in non-small cell lung cancer is associated with poor patient prognoses. J Cancer 10:843-852.
949Yan W et.al. (2019). Identification of B-cell translocation gene 1-controlled gene networks in diffuse large B-cell lymphoma: A study based on bioinformatics analysis. Oncol Lett 17:2825-2835.
948Machado RAC et.al. (2019). CHD7 promotes glioblastoma cell motility and invasiveness through transcriptional modulation of an invasion signature. Sci Rep 9:3952.
947He X et.al. (2019). Increased LGALS3 expression independently predicts shorter overall survival in patients with the proneural subtype of glioblastoma. Cancer Med 8:2031-2040.
946Liu YJ et.al. (2019). Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion. PLoS Genet 15:e1007633.
945Li L et.al. (2019). p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis. Nature 567:253-256.
944Zheng L et.al. (2019). Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells. J Hematol Oncol 12:23.
943Jiang SH et.al. (2019). GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca(2+) signalling in a GABA-independent manner. Gut 68:1994-2006.
942Maurer GD et.al. (2019). Knockdown of the TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Sensitizes Glioma Cells to Hypoxia, Irradiation and Temozolomide. Int J Mol Sci 20:.
941Yang W et.al. (2019). Sortilin promotes glioblastoma invasion and mesenchymal transition through GSK-3beta/beta-catenin/twist pathway. Cell Death Dis 10:208.
940Vriend J et.al. (2019). Differential Expression of Genes for Ubiquitin Ligases in Medulloblastoma Subtypes. Cerebellum 18:469-488.
939Shen A et.al. (2019). Cell division cycle associated 5 promotes colorectal cancer progression by activating the ERK signaling pathway. Oncogenesis 8:19.
938Issaq SH et.al. (2019). Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth. Oncogenesis 8:20.
937Pham-Danis C et.al. (2019). Urea Cycle Sustains Cellular Energetics upon EGFR Inhibition in EGFR-Mutant NSCLC. Mol Cancer Res 17:1351-1364.
936Cimmino F et.al. (2019). HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia. BMC Med Genet 20:37.
935Gao L et.al. (2019). MiR-873/PD-L1 axis regulates the stemness of breast cancer cells. EBioMedicine 41:395-407.
934Yu X et.al. (2019). KIF15 plays a role in promoting the tumorigenicity of melanoma. Exp Eye Res 185:107598.
933Zhou Z et.al. (2019). A C-X-C Chemokine Receptor Type 2-Dominated Cross-talk between Tumor Cells and Macrophages Drives Gastric Cancer Metastasis. Clin Cancer Res 25:3317-3328.
932Wei C et.al. (2019). LPCAT1 promotes brain metastasis of lung adenocarcinoma by up-regulating PI3K/AKT/MYC pathway. J Exp Clin Cancer Res 38:95.
931Wang Y et.al. (2019). A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis. Mol Cancer 18:28.
930Wang Y et.al. (2019). Pancreatic cancer biomarker detection by two support vector strategies for recursive feature elimination. Biomark Med 13:105-121.
929Kant R et.al. (2019). Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma. Sci Rep 9:1968.
928Dou C et.al. (2019). SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production. J Exp Clin Cancer Res 38:70.
927Azimi I et.al. (2019). ORAI1 and ORAI3 in Breast Cancer Molecular Subtypes and the Identification of ORAI3 as a Hypoxia Sensitive Gene and a Regulator of Hypoxia Responses. Cancers (Basel) 11:.
926Tummler C et.al. (2019). SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro. Cancers (Basel) 11:.
925Lee YJ et.al. (2019). Downregulation of PRMT1 promotes the senescence and migration of a non-MYCN amplified neuroblastoma SK-N-SH cells. Sci Rep 9:1771.
924Xu S et.al. (2019). An Integrative Systems Biology and Experimental Approach Identifies Convergence of Epithelial Plasticity, Metabolism, and Autophagy to Promote Chemoresistance. J Clin Med 8:.
923Li X et.al. (2019). Computational Modeling of the Crosstalk Between Macrophage Polarization and Tumor Cell Plasticity in the Tumor Microenvironment. Front Oncol 9:10.
922Spek CA et.al. (2019). Is idiopathic pulmonary fibrosis a cancer-like disease? Transcriptome analysis to fuel the debate. ERJ Open Res 5:.
921Blijlevens M et.al. (2019). High-throughput RNAi screening reveals cancer-selective lethal targets in the RNA spliceosome. Oncogene 38:4142-4153.
920Gamble LD et.al. (2019). Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma. Sci Transl Med 11:.
919Satriyo PB et.al. (2019). Cadherin 11 Inhibition Downregulates beta-catenin, Deactivates the Canonical WNT Signalling Pathway and Suppresses the Cancer Stem Cell-Like Phenotype of Triple Negative Breast Cancer. J Clin Med 8:.
918Wang F et.al. (2019). Nucleolin Is a Functional Binding Protein for Salinomycin in Neuroblastoma Stem Cells. J Am Chem Soc 141:3613-3622.
917Lee YS et.al. (2019). A Computational Framework for Genome-wide Characterization of the Human Disease Landscape. Cell Syst 8:152-162.e6.
916Abaev-Schneiderman E et.al. (2019). SETD3 is a positive regulator of DNA-damage-induced apoptosis. Cell Death Dis 10:74.
915Zhao Y et.al. (2019). MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma. J Exp Clin Cancer Res 38:36.
914Hill BS et.al. (2019). Therapeutic Potential of a Novel alphavbeta(3) Antagonist to Hamper the Aggressiveness of Mesenchymal Triple Negative Breast Cancer Sub-Type. Cancers (Basel) 11:.
913Jeanquartier F et.al. (2019). Use case driven evaluation of open databases for pediatric cancer research. BioData Min 12:2.
912Chlenski A et.al. (2019). Maternal Embryonic Leucine Zipper Kinase (MELK), a Potential Therapeutic Target for Neuroblastoma. Mol Cancer Ther 18:507-516.
911Somers K et.al. (2019). A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene 38:3824-3842.
910Dorstyn L et.al. (2019). Transcriptome profiling of caspase-2 deficient EmuMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling. Cell Death Dis 10:56.
909De Vries LCS et.al. (2019). A JAK1 Selective Kinase Inhibitor and Tofacitinib Affect Macrophage Activation and Function. Inflamm Bowel Dis 25:647-660.
908Jin F et.al. (2019). Impairment of hypoxia-induced angiogenesis by LDL involves a HIF-centered signaling network linking inflammatory TNFalpha and angiogenic VEGF. Aging (Albany NY) 11:328-349.
907Robson JP et.al. (2019). Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells. PLoS One 14:e0210665.
906Cheng X et.al. (2019). ETS variant 5 promotes colorectal cancer angiogenesis by targeting platelet-derived growth factor BB. Int J Cancer 145:179-191.
905Harada T et.al. (2019). Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth. Mol Cancer Ther 18:602-612.
904Mooney MR et.al. (2019). Anti-tumor effect of sulfasalazine in neuroblastoma. Biochem Pharmacol 162:237-249.
903Yang L et.al. (2019). Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation. Oncogenesis 8:3.
902Domizi P et.al. (2019). KDM2B regulates choline kinase expression and neuronal differentiation of neuroblastoma cells. PLoS One 14:e0210207.
901Xu M et.al. (2019). lncRNA SNHG6 regulates EZH2 expression by sponging miR-26a/b and miR-214 in colorectal cancer. J Hematol Oncol 12:3.
900Seitz C et.al. (2019). Multi-faceted inhibition of dendritic cell function by CD4(+)Foxp3(+) regulatory T cells. J Autoimmun 98:86-94.
899Shelake S et.al. (2019). Clotam enhances anti-proliferative effect of vincristine in Ewing sarcoma cells. Apoptosis 24:21-32.
898Savci-Heijink CD et.al. (2019). Epithelial-to-mesenchymal transition status of primary breast carcinomas and its correlation with metastatic behavior. Breast Cancer Res Treat 174:649-659.
897Kim W et.al. (2019). CCAR2/DBC1 and Hsp60 Positively Regulate Expression of Survivin in Neuroblastoma Cells. Int J Mol Sci 20:.
896Shen Y et.al. (2019). S1P/S1PR3 axis promotes aerobic glycolysis by YAP/c-MYC/PGAM1 axis in osteosarcoma. EBioMedicine 40:210-223.
895Bruns I et.al. (2019). Disruption of peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha reverts key features of the neoplastic phenotype of glioma cells. J Biol Chem 294:3037-3050.
894Wang X et.al. (2019). Coexpression network analysis linked H2AFJ to chemoradiation resistance in colorectal cancer. J Cell Biochem 120:10351-10362.
893Westerlund I et.al. (2019). EPAS1/HIF2alpha correlates with features of low-risk neuroblastoma and with adrenal chromaffin cell differentiation during sympathoadrenal development. Biochem Biophys Res Commun 508:1233-1239.
892Nowak-Sliwinska P et.al. (2019). Oncofoetal insulin receptor isoform A marks the tumour endothelium; an underestimated pathway during tumour angiogenesis and angiostatic treatment. Br J Cancer 120:218-228.
891Bai J et.al. (2019). lncRNA A1BG-AS1 suppresses proliferation and invasion of hepatocellular carcinoma cells by targeting miR-216a-5p. J Cell Biochem 120:10310-10322.
890Zhang L et.al. (2019). LncRNA KTN1-AS1 promotes tumor growth of hepatocellular carcinoma by targeting miR-23c/ERBB2IP axis. Biomed Pharmacother 109:1140-1147.
889Le Rhun E et.al. (2019). Profound, durable and MGMT-independent sensitivity of glioblastoma cells to cyclin-dependent kinase inhibition. Int J Cancer 145:242-253.
888Fultang L et.al. (2019). Macrophage-Derived IL1beta and TNFalpha Regulate Arginine Metabolism in Neuroblastoma. Cancer Res 79:611-624.
887Hald OH et.al. (2019). Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene 38:2800-2813.
886Neviani P et.al. (2019). Natural Killer-Derived Exosomal miR-186 Inhibits Neuroblastoma Growth and Immune Escape Mechanisms. Cancer Res 79:1151-1164.
885Narayanan A et.al. (2019). The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1. Cell Death Differ 26:1813-1831.
884Buhl JL et.al. (2019). The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma. Clin Cancer Res 25:1851-1866.
883Navis M et.al. (2019). Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning. EMBO Rep 20:.
882Haruta M et.al. (2019). Combined Genetic and Chromosomal Characterization of Wilms Tumors Identifies Chromosome 12 Gain as a Potential New Marker Predicting a Favorable Outcome. Neoplasia 21:117-131.
881Hu X et.al. (2019). Depletion of Ars2 inhibits cell proliferation and leukemogenesis in acute myeloid leukemia by modulating the miR-6734-3p/p27 axis. Leukemia 33:1090-1101.
880Karachaliou N et.al. (2019). Integrin-linked kinase (ILK) and src homology 2 domain-containing phosphatase 2 (SHP2): Novel targets in EGFR-mutation positive non-small cell lung cancer (NSCLC). EBioMedicine 39:207-214.
879Shi Z et.al. (2019). Distinct roles of histamine H1 Am J Physiol Gastrointest Liver Physiol 316:G205-G216.
878Atkinson A et.al. (2019). Collagen Prolyl Hydroxylases Are Bifunctional Growth Regulators in Melanoma. J Invest Dermatol 139:1118-1126.
877Tegeder I et.al. (2019). Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors. J Neurooncol 141:43-55.
876Arai T et.al. (2019). Pirin: a potential novel therapeutic target for castration-resistant prostate cancer regulated by miR-455-5p. Mol Oncol 13:322-337.
875Hou J et.al. (2019). TROP2 promotes the proliferation and metastasis of glioblastoma cells by activating the JAK2/STAT3 signaling pathway. Oncol Rep 41:753-764.
874Sun C et.al. (2019). Gene expression profiles analysis identifies a novel two-gene signature to predict overall survival in diffuse large B-cell lymphoma. Biosci Rep 39:.
873Cruz-Bermudez A et.al. (2019). Cancer-associated fibroblasts modify lung cancer metabolism involving ROS and TGF-beta signaling. Free Radic Biol Med 130:163-173.
872Chiu CS et.al. (2019). Exploiting Honokiol-induced ER stress CHOP activation inhibits the growth and metastasis of melanoma by suppressing the MITF and beta-catenin pathways. Cancer Lett 442:113-125.
871Muller S et.al. (2019). IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A Nucleic Acids Res 47:375-390.
870Milone MR et.al. (2019). Novel pathways involved in cisplatin resistance identified by a proteomics approach in non-small-cell lung cancer cells. J Cell Physiol 234:9077-9092.
869Laetsch TW et.al. (2019). Larotrectinib for the treatment of TRK fusion solid tumors. Expert Rev Anticancer Ther 19:1-10.
868Ramaswamy V et.al. (2019). Bioinformatic Strategies for the Genomic and Epigenomic Characterization of Brain Tumors. Methods Mol Biol 1869:37-56.
867Li N et.al. (2019). LncRNA and mRNA signatures associated with neoadjuvant chemoradiotherapy downstaging effects in rectal cancer. J Cell Biochem 120:5207-5217.
866Munoz-Galvan S et.al. (2019). Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment. Oncogene 38:1309-1323.
865Ravi A et.al. (2019). Interferon-induced epithelial response to rhinovirus 16 in asthma relates to inflammation and FEV1. J Allergy Clin Immunol 143:442-447.e10.
864Dou C et.al. (2019). Hypoxia-induced TUFT1 promotes the growth and metastasis of hepatocellular carcinoma by activating the Ca(2+)/PI3K/AKT pathway. Oncogene 38:1239-1255.
863Wei Y et.al. (2019). p53 Function Is Compromised by Inhibitor 2 of Phosphatase 2A in Sonic Hedgehog Medulloblastoma. Mol Cancer Res 17:186-198.
862Kato M et.al. (2019). Heterogeneous cancer-associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner. Oncogene 38:716-730.
861Li S et.al. (2019). Shear stress promotes anoikis resistance of cancer cells via caveolin-1-dependent extrinsic and intrinsic apoptotic pathways. J Cell Physiol 234:3730-3743.
860Lieberman NAP et.al. (2019). Characterization of the immune microenvironment of diffuse intrinsic pontine glioma: implications for development of immunotherapy. Neuro Oncol 21:83-94.
859Subbarayan K et.al. (2019). Tumor-dependent Effects of Proteoglycans and Various Glycosaminoglycan Synthesizing Enzymes and Sulfotransferases on Patients Outcome. Curr Cancer Drug Targets 19:210-221.
2018 (n=230)
858Wang D et.al. (2018). The correlation of PTPN4 expression with prognosis in breast cancer. Int J Clin Exp Pathol 11:4845-4853.
857Jolly MK et.al. (2018). Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer. APL Bioeng 2:031908.
856Baali I et.al. (2018). Predicting clinical outcomes in neuroblastoma with genomic data integration. Biol Direct 13:20.
855Hai L et.al. (2018). Jagged1 is Clinically Prognostic and Promotes Invasion of Glioma-Initiating Cells by Activating NF-kappaB(p65) Signaling. Cell Physiol Biochem 51:2925-2937.
854Barros-Silva JD et.al. (2018). Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer. Cell Rep 25:3504-3518.e6.
853Ogorodnikov A et.al. (2018). Transcriptome 3end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma. Nat Commun 9:5331.
852Zhao Z et.al. (2018). microRNA-2110 functions as an onco-suppressor in neuroblastoma by directly targeting Tsukushi. PLoS One 13:e0208777.
851Verhagen HJMP et.al. (2018). IGFBP7 Induces Differentiation and Loss of Survival of Human Acute Myeloid Leukemia Stem Cells without Affecting Normal Hematopoiesis. Cell Rep 25:3021-3035.e5.
850Adam I et.al. (2018). Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation. Oncoimmunology 7:e1486353.
849Qi Y et.al. (2018). Long noncoding RNA HOXD-AS2 regulates cell cycle to promote glioma progression. J Cell Biochem :.
848Tian J et.al. (2018). Dasatinib sensitises triple negative breast cancer cells to chemotherapy by targeting breast cancer stem cells. Br J Cancer 119:1495-1507.
847Li Y et.al. (2018). Zinc finger protein 32 promotes breast cancer stem cell-like properties through directly promoting GPER transcription. Cell Death Dis 9:1162.
846Malgulwar PB et.al. (2018). Transcriptional co-expression regulatory network analysis for Snail and Slug identifies IL1R1, an inflammatory cytokine receptor, to be preferentially expressed in ST-EPN-RELA and PF-EPN-A molecular subgroups of intracranial ependymomas. Oncotarget 9:35480-35492.
845Van den Eynden J et.al. (2018). Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways. Sci Signal 11:.
844Wang D et.al. (2018). Clinical Significance of Elevated S100A8 Expression in Breast Cancer Patients. Front Oncol 8:496.
843Decaesteker B et.al. (2018). TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets. Nat Commun 9:4866.
842Smirnov A et.al. (2018). ZNF185 is a p53 target gene following DNA damage. Aging (Albany NY) 10:3308-3326.
841Abballe L et.al. (2018). Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells. Front Pediatr 6:315.
840Veenstra VL et.al. (2018). ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy. Oncogenesis 7:87.
839Camorani S et.al. (2018). Targeted imaging and inhibition of triple-negative breast cancer metastases by a PDGFRbeta aptamer. Theranostics 8:5178-5199.
838Bachmann AS et.al. (2018). Polyamine synthesis as a target of MYC oncogenes. J Biol Chem 293:18757-18769.
837Zaman S et.al. (2018). MAPT (Tau) expression is a biomarker for an increased rate of survival in pediatric neuroblastoma. Cell Cycle 17:2474-2483.
836Hu D et.al. (2018). KDM5A Regulates a Translational Program that Controls p53 Protein Expression. iScience 9:84-100.
835Schipp C et.al. (2018). EBV Negative Lymphoma and Autoimmune Lymphoproliferative Syndrome Like Phenotype Extend the Clinical Spectrum of Primary Immunodeficiency Caused by STK4 Deficiency. Front Immunol 9:2400.
834Depuydt P et.al. (2018). Meta-mining of copy number profiles of high-risk neuroblastoma tumors. Sci Data 5:180240.
833Gu Y et.al. (2018). The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation. J Exp Clin Cancer Res 37:258.
832Abarrategi A et.al. (2018). c-Fos induces chondrogenic tumor formation in immortalized human mesenchymal progenitor cells. Sci Rep 8:15615.
831Su C et.al. (2018). TRIM28 is overexpressed in glioma and associated with tumor progression. Onco Targets Ther 11:6447-6458.
830Brabetz S et.al. (2018). A biobank of patient-derived pediatric brain tumor models. Nat Med 24:1752-1761.
829Fekry B et.al. (2018). Incompatibility of the circadian protein BMAL1 and HNF4alpha in hepatocellular carcinoma. Nat Commun 9:4349.
828Wang F et.al. (2018). Identification of a panel of genes as a prognostic biomarker for glioblastoma. EBioMedicine 37:68-77.
827Clark CR et.al. (2018). Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene. Sci Rep 8:15327.
826Deng Q et.al. (2018). PHF19 promotes the proliferation, migration, and chemosensitivity of glioblastoma to doxorubicin through modulation of the SIAH1/beta-catenin axis. Cell Death Dis 9:1049.
825van der Waals LM et.al. (2018). ALDH1A1 expression is associated with poor differentiation, right-sidedness and poor survival in human colorectal cancer. PLoS One 13:e0205536.
824La T et.al. (2018). A p53-Responsive miRNA Network Promotes Cancer Cell Quiescence. Cancer Res 78:6666-6679.
823Gao AW et.al. (2018). Identification of key pathways and metabolic fingerprints of longevity in C. elegans. Exp Gerontol 113:128-140.
822Saha SK et.al. (2018). Systematic expression alteration analysis of master reprogramming factor OCT4 and its three pseudogenes in human cancer and their prognostic outcomes. Sci Rep 8:14806.
821Brassesco MS et.al. (2018). TLE1 as an indicator of adverse prognosis in pediatric acute lymphoblastic leukemia. Leuk Res 74:42-46.
820Liu Z et.al. (2018). Hypoxia-induced up-regulation of VASP promotes invasiveness and metastasis of hepatocellular carcinoma. Theranostics 8:4649-4663.
819Fan J et.al. (2018). miR124 inhibits cell growth through targeting IQGAP1 in colorectal cancer. Mol Med Rep 18:5270-5278.
818Lehrer S et.al. (2018). Increased expression of von Willebrand factor gene is associated with poorer survival in primary lower grade glioma. Glioma 1:132-135.
817Gachet S et.al. (2018). Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation. Cancer Discov 8:1614-1631.
816Hussain S et.al. (2018). UCH-L1 bypasses mTOR to promote protein biosynthesis and is required for MYC-driven lymphomagenesis in mice. Blood 132:2564-2574.
815Zhang Y et.al. (2018). Down-regulation of Skp2 expression inhibits invasion and lung metastasis in osteosarcoma. Sci Rep 8:14294.
814Das S et.al. (2018). beta7 integrins contribute to intestinal tumor growth in mice. PLoS One 13:e0204181.
813Li Z et.al. (2018). EYA4 Promotes Cell Proliferation Through Downregulation of p27Kip1 in Glioma. Cell Physiol Biochem 49:1856-1869.
812Al-Zoughbi W et.al. (2018). Early Loss of Forkhead Transcription Factor, O Subgroup, Member 1 Protein in the Development of Pancreatic Ductal Adenocarcinoma. Pathobiology 85:342-347.
811Wu D et.al. (2018). Hepatitis B virus-X protein regulates high mobility group box 1 to promote the formation of hepatocellular carcinoma. Oncol Lett 16:4418-4426.
810Haro M et.al. (2018). A Paradoxical Correlation of Cancer-Associated Fibroblasts With Survival Outcomes in B-Cell Lymphomas and Carcinomas. Front Cell Dev Biol 6:98.
809Forget A et.al. (2018). Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling. Cancer Cell 34:379-395.e7.
808Lehrer S et.al. (2018). Expression of the Vesicular Monoamine Transporter Gene Solute Carrier Family 18 Member 1 (SLC18A1) in Lung Cancer. Cancer Genomics Proteomics 15:387-393.
807Tekin C et.al. (2018). PAR1 signaling on tumor cells limits tumor growth by maintaining a mesenchymal phenotype in pancreatic cancer. Oncotarget 9:32010-32023.
806Han B et.al. (2018). Identification and Interaction Analysis of Molecular Markers in Colorectal Cancer by Integrated Bioinformatics Analysis. Med Sci Monit 24:6059-6069.
805Petroni M et.al. (2018). MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors. Cell Death Dis 9:895.
804Li Z et.al. (2018). SNHG6 Promotes Tumor Growth via Repression of P21 in Colorectal Cancer. Cell Physiol Biochem 49:463-478.
803Braekeveldt N et.al. (2018). Patient-Derived Xenograft Models Reveal Intratumor Heterogeneity and Temporal Stability in Neuroblastoma. Cancer Res 78:5958-5969.
802Yamada Y et.al. (2018). Molecular pathogenesis of renal cell carcinoma: Impact of the anti-tumor miR-29 family on gene regulation. Int J Urol 25:953-965.
801Greenhough A et.al. (2018). Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis. EMBO Mol Med 10:.
800Cimmino F et.al. (2018). Fine mapping of 2q35 high-risk neuroblastoma locus reveals independent functional risk variants and suggests full-length BARD1 as tumor-suppressor. Int J Cancer 143:2828-2837.
799Morgan MJ et.al. (2018). Metastatic cells are preferentially vulnerable to lysosomal inhibition. Proc Natl Acad Sci U S A 115:E8479-E8488.
798Weicht RR et.al. (2018). Polyamine Biosynthetic Pathway as a Drug Target for Osteosarcoma Therapy. Med Sci (Basel) 6:.
797Eleveld TF et.al. (2018). RAS-MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma. Cancer Res 78:6297-6307.
796Li C et.al. (2018). PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism. Dev Cell 46:441-455.e8.
795Po A et.al. (2018). Sonic Hedgehog Medulloblastoma Cancer Stem Cells Mirnome and Transcriptome Highlight Novel Functional Networks. Int J Mol Sci 19:.
794Weng Y et.al. (2018). The miR-15b-5p/PDK4 axis regulates osteosarcoma proliferation through modulation of the Warburg effect. Biochem Biophys Res Commun 503:2749-2757.
793Hu R et.al. (2018). RNA-binding protein PUM2 suppresses osteosarcoma progression via partly and competitively binding to STARD13 3UTR with miRNAs. Cell Prolif 51:e12508.
792Kim HJ et.al. (2018). DBC1 regulates Wnt/beta-catenin-mediated expression of MACC1, a key regulator of cancer progression, in colon cancer. Cell Death Dis 9:831.
791Malgulwar PB et.al. (2018). Epithelial-to-mesenchymal transition-related transcription factors are up-regulated in ependymomas and correlate with a poor prognosis. Hum Pathol 82:149-157.
790Liu J et.al. (2018). CLEC3B is downregulated and inhibits proliferation in clear cell renal cell carcinoma. Oncol Rep 40:2023-2035.
789Dudvarski Stankovic N et.al. (2018). EGFL7 enhances surface expression of integrin alpha5beta1 to promote angiogenesis in malignant brain tumors. EMBO Mol Med 10:.
788Meel MH et.al. (2018). MELK Inhibition in Diffuse Intrinsic Pontine Glioma. Clin Cancer Res 24:5645-5657.
787Shen J et.al. (2018). Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer. J Exp Clin Cancer Res 37:175.
786Heller S et.al. (2018). Gene Suppression of Transketolase-Like Protein 1 (TKTL1) Sensitizes Glioma Cells to Hypoxia and Ionizing Radiation. Int J Mol Sci 19:.
785van der Waals LM et.al. (2018). Increased Levels of Oxidative Damage in Liver Metastases Compared with Corresponding Primary Colorectal Tumors: Association with Molecular Subtype and Prior Treatment. Am J Pathol 188:2369-2377.
784Gao W et.al. (2018). Ketohexokinase is involved in fructose utilization and promotes tumor progression in glioma. Biochem Biophys Res Commun 503:1298-1306.
783Yao Y et.al. (2018). Blockade of deubiquitinase USP7 overcomes bortezomib resistance by suppressing NF-kappaB signaling pathway in multiple myeloma. J Leukoc Biol 104:1105-1115.
782Kerosuo L et.al. (2018). Enhanced expression of MycN/CIP2A drives neural crest toward a neural stem cell-like fate: Implications for priming of neuroblastoma. Proc Natl Acad Sci U S A 115:E7351-E7360.
781Cavalli FMG et.al. (2018). Heterogeneity within the PF-EPN-B ependymoma subgroup. Acta Neuropathol 136:227-237.
780Li T et.al. (2018). Brutons tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma. Oncogene 37:6180-6194.
779Bielli P et.al. (2018). The Splicing Factor PTBP1 Promotes Expression of Oncogenic Splice Variants and Predicts Poor Prognosis in Patients with Non-muscle-Invasive Bladder Cancer. Clin Cancer Res 24:5422-5432.
778Breunig C et.al. (2018). TGFbeta1 regulates HGF-induced cell migration and hepatocyte growth factor receptor MET expression via C-ets-1 and miR-128-3p in basal-like breast cancer. Mol Oncol 12:1447-1463.
777Gambera S et.al. (2018). Role of Activator Protein-1 Complex on the Phenotype of Human Osteosarcomas Generated from Mesenchymal Stem Cells. Stem Cells 36:1487-1500.
776Akgul S et.al. (2018). Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma. Cell Rep 24:463-478.e5.
775Idichi T et.al. (2018). Involvement of anti-tumor miR-124-3p and its targets in the pathogenesis of pancreatic ductal adenocarcinoma: direct regulation of ITGA3 and ITGB1 by miR-124-3p. Oncotarget 9:28849-28865.
774Lehrer S et.al. (2018). Loss of MycBP may be associated with the improved survival in 1P co-deletion of lower grade glioma patients. Clin Neurol Neurosurg 172:112-115.
773Liang KH et.al. (2018). Extracellular domain of EpCAM enhances tumor progression through EGFR signaling in colon cancer cells. Cancer Lett 433:165-175.
772Uhl KL et.al. (2018). Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma. Cancer Cell Int 18:82.
771Lehrer S et.al. (2018). Glioblastoma Multiforme: Fewer Tumor Copy Number Segments of the SGK1 Gene Are Associated with Poorer Survival. Cancer Genomics Proteomics 15:273-278.
770Tao Y et.al. (2018). Alternative NF-kappaB signaling promotes colorectal tumorigenesis through transcriptionally upregulating Bcl-3. Oncogene 37:5887-5900.
769Yamada Y et.al. (2018). Regulation of antitumor miR-144-5p targets oncogenes: Direct regulation of syndecan-3 and its clinical significance. Cancer Sci 109:2919-2936.
768Santhana Kumar K et.al. (2018). TGF-beta Determines the Pro-migratory Potential of bFGF Signaling in Medulloblastoma. Cell Rep 23:3798-3812.e8.
767Pieraccioli M et.al. (2018). ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma. Proc Natl Acad Sci U S A 115:7356-7361.
766Mansour MR et.al. (2018). JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. J Exp Med 215:1929-1945.
765Bettinsoli P et.al. (2018). Favorable prognostic role of tropomodulins in neuroblastoma. Oncotarget 9:27092-27103.
764Liang L et.al. (2018). CD271(+) Cells Are Diagnostic and Prognostic and Exhibit Elevated MAPK Activity in SHH Medulloblastoma. Cancer Res 78:4745-4759.
763Duan K et.al. (2018). Lactic acid induces lactate transport and glycolysis/OXPHOS interconversion in glioblastoma. Biochem Biophys Res Commun 503:888-894.
762Ou-Yang Q et.al. (2018). TRPV4 promotes the migration and invasion of glioma cells via AKT/Rac1 signaling. Biochem Biophys Res Commun 503:876-881.
761Yamada Y et.al. (2018). Anti-tumor roles of both strands of the miR-455 duplex: their targets SKA1 and SKA3 are involved in the pathogenesis of renal cell carcinoma. Oncotarget 9:26638-26658.
760Lee NH et.al. (2018). SERPINB2 is a novel indicator of stem cell toxicity. Cell Death Dis 9:724.
759Bruggeman JW et.al. (2018). Massive expression of germ cell-specific genes is a hallmark of cancer and a potential target for novel treatment development. Oncogene 37:5694-5700.
758Hua T et.al. (2018). Estrogenrelated receptor gamma promotes the migration and metastasis of endometrial cancer cells by targeting S100A4. Oncol Rep 40:823-832.
757Ognibene M et.al. (2018). CHL1 gene acts as a tumor suppressor in human neuroblastoma. Oncotarget 9:25903-25921.
756Chen C et.al. (2018). Downregulation of histone demethylase JMJD1C inhibits colorectal cancer metastasis through targeting ATF2. Am J Cancer Res 8:852-865.
755Mari L et.al. (2018). microRNA 125a Regulates MHC-I Expression on Esophageal Adenocarcinoma Cells, Associated With Suppression of Antitumor Immune Response and Poor Outcomes of Patients. Gastroenterology 155:784-798.
754Tranchevent LC et.al. (2018). Predicting clinical outcome of neuroblastoma patients using an integrative network-based approach. Biol Direct 13:12.
753Li Y et.al. (2018). miR-1268a regulates ABCC1 expression to mediate temozolomide resistance in glioblastoma. J Neurooncol 138:499-508.
752Bader S et.al. (2018). Effect of the actin Biochem J 475:2057-2071.
751Han T et.al. (2018). Forkhead box D1 promotes proliferation and suppresses apoptosis via regulating polo-like kinase 2 in colorectal cancer. Biomed Pharmacother 103:1369-1375.
750Zheng L et.al. (2018). STARD13-correlated ceRNA network-directed inhibition on YAP/TAZ activity suppresses stemness of breast cancer via co-regulating Hippo and Rho-GTPase/F-actin signaling. J Hematol Oncol 11:72.
749Gu C et.al. (2018). FSTL1 interacts with VIM and promotes colorectal cancer metastasis via activating the focal adhesion signalling pathway. Cell Death Dis 9:654.
748Tripolitsioti D et.al. (2018). MAP4K4 controlled integrin beta1 activation and c-Met endocytosis are associated with invasive behavior of medulloblastoma cells. Oncotarget 9:23220-23236.
747Liu XL et.al. (2018). [Effect of 1q21 amplification on bortezomib therapeutic response and prognosis of newly diagnosed multiple myeloma patients]. Zhonghua Xue Ye Xue Za Zhi 39:408-413.
746De Santo C et.al. (2018). Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma. J Hematol Oncol 11:68.
745Lochmann TL et.al. (2018). Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma. Sci Transl Med 10:.
744Yi L et.al. (2018). Bioinformatic analyses reveal the key pathways and genes in the CXCR4 mediated mesenchymal subtype of glioblastoma. Mol Med Rep 18:741-748.
743Taye N et.al. (2018). SMAR1 inhibits Wnt/beta-catenin signaling and prevents colorectal cancer progression. Oncotarget 9:21322-21336.
742Miyazaki M et.al. (2018). The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas. Cell Death Discov 4:56.
741Liu C et.al. (2018). PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids. Proc Natl Acad Sci U S A 115:E5066-E5075.
740Agarwal S et.al. (2018). MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma. Oncotarget 9:20323-20338.
739Lehrer S et.al. (2018). In primary glioblastoma fewer tumor copy number segments of the F13A1 gene are associated with poorer survival. Thromb Res 167:12-14.
738Menard M et.al. (2018). Hey1 PLoS Biol 16:e2002912.
737Ishizuka Y et.al. (2018). NRP1 knockdown promotes the migration and invasion of human neuroblastoma-derived SKNAS cells via the activation of beta1 integrin expression. Int J Oncol 53:159-166.
736Tong L et.al. (2018). Tumour cell dormancy as a contributor to the reduced survival of GBM patients who received standard therapy. Oncol Rep 40:463-471.
735Parry AJ et.al. (2018). NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence. Nat Commun 9:1840.
734Chai P et.al. (2018). Dynamic chromosomal tuning of a novel GAU1 lncing driver at chr12p13.32 accelerates tumorigenesis. Nucleic Acids Res 46:6041-6056.
733Zhang T et.al. (2018). Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis. BMC Cancer 18:536.
732Wang Y et.al. (2018). Neutrophils infiltrating pancreatic ductal adenocarcinoma indicate higher malignancy and worse prognosis. Biochem Biophys Res Commun 501:313-319.
731Liu Q et.al. (2018). SPOCD1 promotes the proliferation and metastasis of glioma cells by up-regulating PTX3. Am J Cancer Res 8:624-635.
730Zheng L et.al. (2018). RNA Binding Protein RNPC1 Inhibits Breast Cancer Cell Metastasis via Activating STARD13-Correlated ceRNA Network. Mol Pharm 15:2123-2132.
729Trumpi K et.al. (2018). Macrophages induce budding in aggressive human colon cancer subtypes by protease-mediated disruption of tight junctions. Oncotarget 9:19490-19507.
728Padua MB et.al. (2018). Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis. Breast Cancer Res 20:35.
727Engel N et.al. (2018). First evidence of SGPL1 expression in the cell membrane silencing the extracellular S1P siren in mammary epithelial cells. PLoS One 13:e0196854.
726Madhav A et.al. (2018). Antagonizing CD105 enhances radiation sensitivity in prostate cancer. Oncogene 37:4385-4397.
725Sanghez V et.al. (2018). Efficacy of Asparaginase Erwinia chrysanthemi With and Without Temozolomide Against Glioma Cells and Intracranial Mouse Medulloblastoma. Anticancer Res 38:2627-2634.
724Berenguer J et.al. (2018). Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8. J Extracell Vesicles 7:1446660.
723Chen J et.al. (2018). Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages. Cell Physiol Biochem 46:1693-1703.
722E Hermosilla V et.al. (2018). SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes. Mol Oncol 12:1026-1046.
721Sime W et.al. (2018). BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma. Cell Death Dis 9:458.
720Kuipers AJ et.al. (2018). TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4. Biochim Biophys Acta Mol Basis Dis 1864:2409-2419.
719Xu Q et.al. (2018). MicroRNA-876-5p inhibits epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by targeting BCL6 corepressor like 1. Biomed Pharmacother 103:645-652.
718Muller S et.al. (2018). IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors. Nucleic Acids Res 46:6285-6303.
717Chen D et.al. (2018). Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma. Bone Res 6:11.
716Park JW et.al. (2018). Sprouty2 enhances the tumorigenic potential of glioblastoma cells. Neuro Oncol 20:1044-1054.
715Subbarayan K et.al. (2018). Biglycan-mediated upregulation of MHC class I expression in HER-2/neu-transformed cells. Oncoimmunology 7:e1373233.
714Joly AL et.al. (2018). Alternative Splicing of FOXP3 Controls Regulatory T Cell Effector Functions and Is Associated With Human Atherosclerotic Plaque Stability. Circ Res 122:1385-1394.
713Stephenson L et.al. (2018). Building online genomics applications using BioPyramid. Bioinformatics 34:3055-3057.
712Wu Y et.al. (2018). Suv4-20h1 promotes G1 to S phase transition by downregulating p21(WAF1/CIP1) expression in chronic myeloid leukemia K562 cells. Oncol Lett 15:6123-6130.
711Mettang M et.al. (2018). Blocking distinct interactions between Glioblastoma cells and their tissue microenvironment: A novel multi-targeted therapeutic approach. Sci Rep 8:5527.
710Orlando D et.al. (2018). Adoptive Immunotherapy Using PRAME-Specific T Cells in Medulloblastoma. Cancer Res 78:3337-3349.
709Khanna S et.al. (2018). Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients. Clin Cancer Res 24:2859-2872.
708Valvona CJ et.al. (2018). Oxamate, but Not Selective Targeting of LDH-A, Inhibits Medulloblastoma Cell Glycolysis, Growth and Motility. Brain Sci 8:.
707Xu W et.al. (2018). Knockdown of HuR represses osteosarcoma cells migration, invasion and stemness through inhibition of YAP activation and increases susceptibility to chemotherapeutic agents. Biomed Pharmacother 102:587-593.
706Hamidian A et.al. (2018). Promoter-associated proteins of EPAS1 identified by enChIP-MS Biochem Biophys Res Commun 499:291-298.
705Nikitovic D et.al. (2018). Proteoglycans-Biomarkers and Targets in Cancer Therapy. Front Endocrinol (Lausanne) 9:69.
704Kawano Y et.al. (2018). Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression. J Clin Invest 128:2487-2499.
703Neidert MC et.al. (2018). The natural HLA ligandome of glioblastoma stem-like cells: antigen discovery for T cell-based immunotherapy. Acta Neuropathol 135:923-938.
702He J et.al. (2018). Cancer-testis specific gene OIP5: a downstream gene of E2F1 that promotes tumorigenesis and metastasis in glioblastoma by stabilizing E2F1 signaling. Neuro Oncol 20:1173-1184.
701Hossain MM et.al. (2018). Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death. Oncotarget 9:11707-11721.
700Revert F et.al. (2018). Selective targeting of collagen IV in the cancer cell microenvironment reduces tumor burden. Oncotarget 9:11020-11045.
699Li C et.al. (2018). Long non-coding RNA KCNQ1OT1 mediates the growth of hepatocellular carcinoma by functioning as a competing endogenous RNA of miR-504. Int J Oncol 52:1603-1612.
698Tan IL et.al. (2018). Lateral cerebellum is preferentially sensitive to high sonic hedgehog signaling and medulloblastoma formation. Proc Natl Acad Sci U S A 115:3392-3397.
697Wang H et.al. (2018). HER4 promotes cell survival and chemoresistance in osteosarcoma via interaction with NDRG1. Biochim Biophys Acta Mol Basis Dis 1864:1839-1849.
696Zhao SJ et.al. (2018). SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway. Cell Death Dis 9:390.
695Ma Y et.al. (2018). The tumor suppressive miR-26a regulation of FBXO11 inhibits proliferation, migration and invasion of hepatocellular carcinoma cells. Biomed Pharmacother 101:648-655.
694Shen J et.al. (2018). A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment. Cell Death Differ 25:2053-2070.
693Depuydt P et.al. (2018). Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients. J Natl Cancer Inst 110:1084-1093.
692Paquet-Fifield S et.al. (2018). Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells. Cancer Res 78:2925-2938.
691Garcia-Heredia JM et.al. (2018). NUMB and NUMBL differences in gene regulation. Oncotarget 9:9219-9234.
690Boulagnon-Rombi C et.al. (2018). LRP1 expression in colon cancer predicts clinical outcome. Oncotarget 9:8849-8869.
689Li Z et.al. (2018). EZH2 regulates neuroblastoma cell differentiation via NTRK1 promoter epigenetic modifications. Oncogene 37:2714-2727.
688Szemes M et.al. (2018). Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma. Neoplasia 20:335-350.
687Fregni G et.al. (2018). Reciprocal modulation of mesenchymal stem cells and tumor cells promotes lung cancer metastasis. EBioMedicine 29:128-145.
686Michaelsen SR et.al. (2018). DNA Methylation Levels of the ELMO Gene Promoter CpG Islands in Human Glioblastomas. Int J Mol Sci 19:.
685Ferrucci V et.al. (2018). Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-beta-OTX2-SNAIL via PTEN inhibition. Brain 141:1300-1319.
684Grobner SN et.al. (2018). The landscape of genomic alterations across childhood cancers. Nature 555:321-327.
683Floros KV et.al. (2018). Coamplification of miR-4728 protects HER2-amplified breast cancers from targeted therapy. Proc Natl Acad Sci U S A 115:E2594-E2603.
682OBrien EM et.al. (2018). The long non-coding RNA MYCNOS-01 regulates MYCN protein levels and affects growth of MYCN-amplified rhabdomyosarcoma and neuroblastoma cells. BMC Cancer 18:217.
681Long W et.al. (2018). PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4. J Mol Cell Biol 10:147-160.
680Jin F et.al. (2018). High-density lipoprotein (HDL) promotes angiogenesis via S1P3-dependent VEGFR2 activation. Angiogenesis 21:381-394.
679Sun H et.al. (2018). CFTR mutation enhances Dishevelled degradation and results in impairment of Wnt-dependent hematopoiesis. Cell Death Dis 9:275.
678Brunen D et.al. (2018). PIM Kinases Are a Potential Prognostic Biomarker and Therapeutic Target in Neuroblastoma. Mol Cancer Ther 17:849-857.
677Li W et.al. (2018). Sirtuin7 has an oncogenic potential via promoting the growth of cholangiocarcinoma cells. Biomed Pharmacother 100:257-266.
676Karachaliou N et.al. (2018). Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-smallcell Lung Cancer Associated With Poor Prognosis. EBioMedicine 29:112-127.
675Yu Y et.al. (2018). Tumor suppressive ZBTB4 inhibits cell growth by regulating cell cycle progression and apoptosis in Ewing sarcoma. Biomed Pharmacother 100:108-115.
674Guan S et.al. (2018). MELK is a novel therapeutic target in high-risk neuroblastoma. Oncotarget 9:2591-2602.
673Arnhold V et.al. (2018). Reactivating TP53 signaling by the novel MDM2 inhibitor DS-3032b as a therapeutic option for high-risk neuroblastoma. Oncotarget 9:2304-2319.
672Tian T et.al. (2018). SNHG1 promotes cell proliferation by acting as a sponge of miR-145 in colorectal cancer. Oncotarget 9:2128-2139.
671Yanru W et.al. (2018). Transcriptomic analyses of chemokines reveal that down-regulation of XCR1 is associated with advanced hepatocellular carcinoma. Biochem Biophys Res Commun 496:1314-1321.
670Ferrucci F et.al. (2018). MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma. Biochim Biophys Acta Gene Regul Mech 1861:235-245.
669Zhang H et.al. (2018). Expression profile and clinical significance of Wnt signaling in human gliomas. Oncol Lett 15:610-617.
668Gross A et.al. (2018). Tumorigenic and Antiproliferative Properties of the TALE-Transcription Factors MEIS2D and MEIS2A in Neuroblastoma. Cancer Res 78:1935-1947.
667Xiang S et.al. (2018). LncRNA IDH1-AS1 links the functions of c-Myc and HIF1alpha via IDH1 to regulate the Warburg effect. Proc Natl Acad Sci U S A 115:E1465-E1474.
666Dzieran J et.al. (2018). MYCN-amplified neuroblastoma maintains an aggressive and undifferentiated phenotype by deregulation of estrogen and NGF signaling. Proc Natl Acad Sci U S A 115:E1229-E1238.
665Folgiero V et.al. (2018). Che-1 is targeted by c-Myc to sustain proliferation in pre-B-cell acute lymphoblastic leukemia. EMBO Rep 19:.
664Yuan R et.al. (2018). Chk1 and 14-3-3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest. EMBO J 37:.
663Wu Q et.al. (2018). miR-375 inhibits IFN-gamma-induced programmed death 1 ligand 1 surface expression in head and neck squamous cell carcinoma cells by blocking JAK2/STAT1 signaling. Oncol Rep 39:1461-1468.
662Li X et.al. (2018). Retinoic acid promotes stem cell differentiation and embryonic development by transcriptionally activating CFTR. Biochim Biophys Acta Mol Cell Res 1865:605-615.
661Hasna J et.al. (2018). Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection. Cell Death Differ 25:693-707.
660Chen S et.al. (2018). EZH2 promotes hepatocellular carcinoma progression through modulating miR-22/galectin-9 axis. J Exp Clin Cancer Res 37:3.
659Zhang Y et.al. (2018). YAP Promotes Migration and Invasion of Human Glioma Cells. J Mol Neurosci 64:262-272.
658Schultz CR et.al. (2018). Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma. Biochem J 475:531-545.
657Sun C et.al. (2018). F-box protein 11 promotes the growth and metastasis of gastric cancer via PI3K/AKT pathway-mediated EMT. Biomed Pharmacother 98:416-423.
656Han B et.al. (2018). FOXC1-induced non-canonical WNT5A-MMP7 signaling regulates invasiveness in triple-negative breast cancer. Oncogene 37:1399-1408.
655Khodaparast S et.al. (2018). Dewetting of Thin Liquid Films Surrounding Air Bubbles in Microchannels. Langmuir 34:1363-1370.
654Zhang T et.al. (2018). The atypical protein kinase RIOK3 contributes to glioma cell proliferation/survival, migration/invasion and the AKT/mTOR signaling pathway. Cancer Lett 415:151-163.
653Agrawal R et.al. (2018). p53 and miR-210 regulated NeuroD2, a neuronal basic helix-loop-helix transcription factor, is downregulated in glioblastoma patients and functions as a tumor suppressor under hypoxic microenvironment. Int J Cancer 142:1817-1828.
652Koster R et.al. (2018). Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients. Int J Cancer 142:1594-1601.
651Zhang B et.al. (2018). Neuroglobin promotes the proliferation and suppresses the apoptosis of glioma cells by activating the PI3K/AKT pathway. Mol Med Rep 17:2757-2763.
650Flannery PC et.al. (2018). Preclinical analysis of MTOR complex 1/2 inhibition in diffuse intrinsic pontine glioma. Oncol Rep 39:455-464.
649Wang Z et.al. (2018). RNA binding protein Lin28A promotes osteocarcinoma cells progression by associating with the long noncoding RNA MALAT1. Biotechnol Lett 40:493-500.
648Lucena-Cacace A et.al. (2018). NAMPT Is a Potent Oncogene in Colon Cancer Progression that Modulates Cancer Stem Cell Properties and Resistance to Therapy through Sirt1 and PARP. Clin Cancer Res 24:1202-1215.
647Liu SM et.al. (2018). miR-596 Modulates Melanoma Growth by Regulating Cell Survival and Death. J Invest Dermatol 138:911-921.
646Hwang I et.al. (2018). FOXO protects against age-progressive axonal degeneration. Aging Cell 17:.
645Meel MH et.al. (2018). Signaling pathways and mesenchymal transition in pediatric high-grade glioma. Cell Mol Life Sci 75:871-887.
644Bogeas A et.al. (2018). Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness. Acta Neuropathol 135:267-283.
643Panchoo M et.al. (2018). Scavenger receptor class B type 1 regulates neuroblastoma cell proliferation, migration and invasion. Biochem Biophys Res Commun 495:614-620.
642Lochmann TL et.al. (2018). Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression. Clin Cancer Res 24:360-369.
641Huang Y et.al. (2018). Three-dimensional hydrogel is suitable for targeted investigation of amoeboid migration of glioma cells. Mol Med Rep 17:250-256.
640Zhao SJ et.al. (2018). SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/beta-catenin signaling through stabilization of the WNT-receptor complex. Oncogene 37:1049-1061.
639Deng S et.al. (2018). Overexpression of COX7A2 is associated with a good prognosis in patients with glioma. J Neurooncol 136:41-50.
638Song KA et.al. (2018). Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM. Clin Cancer Res 24:197-208.
637Marturano-Kruik A et.al. (2018). Biomechanical regulation of drug sensitivity in an engineered model of human tumor. Biomaterials 150:150-161.
636Pahlman S et.al. (2018). Hypoxia and hypoxia-inducible factors in neuroblastoma. Cell Tissue Res 372:269-275.
635Ge Z et.al. (2018). Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia. Epigenomics 10:59-69.
634Wang CH et.al. (2018). Resistin facilitates breast cancer progression via TLR4-mediated induction of mesenchymal phenotypes and stemness properties. Oncogene 37:589-600.
633Narayan RS et.al. (2018). Identification of MEK162 as a Radiosensitizer for the Treatment of Glioblastoma. Mol Cancer Ther 17:347-354.
632Xie Z et.al. (2018). miR-149 promotes human osteocarcinoma progression via targeting bone morphogenetic protein 9 (BMP9). Biotechnol Lett 40:47-55.
631Rifatbegovic F et.al. (2018). Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression. Int J Cancer 142:297-307.
630Hasenoehrl C et.al. (2018). G protein-coupled receptor GPR55 promotes colorectal cancer and has opposing effects to cannabinoid receptor 1. Int J Cancer 142:121-132.
629Choo S et.al. (2018). Reactivation of TWIST1 contributes to Ewing sarcoma metastasis. Pediatr Blood Cancer 65:.
2017 (n=171)
628Leong WZ et.al. (2017). ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis. Genes Dev 31:2343-2360.
627Lange I et.al. (2017). FTY-720 induces apoptosis in neuroblastoma via multiple signaling pathways. Oncotarget 8:109985-109999.
626Mu L et.al. (2017). Small-sized colorectal cancer cells harbor metastatic tumor-initiating cells. Oncotarget 8:107907-107919.
625Su Z et.al. (2017). Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes. Oncotarget 8:106296-106310.
624Verdugo-Sivianes EM et.al. (2017). Coordinated downregulation of Spinophilin and the catalytic subunits of PP1, PPP1CA/B/C, contributes to a worse prognosis in lung cancer. Oncotarget 8:105196-105210.
623Arrizabalaga O et.al. (2017). High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response. Oncogenesis 6:401.
622Gong L et.al. (2017). Differential radiation response between normal astrocytes and glioma cells revealed by comparative transcriptome analysis. Onco Targets Ther 10:5755-5764.
621Mucignat-Caretta C et.al. (2017). Protein Kinase A Distribution Differentiates Human Glioblastoma from Brain Tissue. Cancers (Basel) 10:.
620Chen Z et.al. (2017). Small molecule inhibitor regorafenib inhibits RET signaling in neuroblastoma cells and effectively suppresses tumor growth in vivo. Oncotarget 8:104090-104103.
619Astrologo L et.al. (2017). ALK1Fc Suppresses the Human Prostate Cancer Growth in in Vitro and in Vivo Preclinical Models. Front Cell Dev Biol 5:104.
618Lucena-Cacace A et.al. (2017). NAMPT overexpression induces cancer stemness and defines a novel tumor signature for glioma prognosis. Oncotarget 8:99514-99530.
617Sankar S et.al. (2017). Geminin deficiency enhances survival in a murine medulloblastoma model by inducing apoptosis of preneoplastic granule neuron precursors. Genes Cancer 8:725-744.
616Mohlin S et.al. (2017). No reason to reconsider HIF-2 as an oncogene in neuroblastoma and other cancer forms. Proc Natl Acad Sci U S A 114:E10856-E10858.
615Garcia-Heredia JM et.al. (2017). The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment. Oncotarget 8:98580-98597.
614Hou J et.al. (2017). Increased Jab1/COPS5 is associated with therapeutic response and adverse outcome in lung cancer and breast cancer patients. Oncotarget 8:97504-97515.
613Yuan ZS et.al. (2017). IGFBP2 induces SPRY1 expression via NF-kappaB signaling pathway in glioblastoma multiforme (GBM). Eur Rev Med Pharmacol Sci 21:5072-5080.
612Tummler C et.al. (2017). Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo. Oncotarget 8:95135-95151.
611Sun W et.al. (2017). EWS-FLI1 and RNA helicase A interaction inhibitor YK-4-279 inhibits growth of neuroblastoma. Oncotarget 8:94780-94792.
610Linares-Clemente P et.al. (2017). Neural crest derived progenitor cells contribute to tumor stroma and aggressiveness in stage 4/M neuroblastoma. Oncotarget 8:89775-89792.
609Villasante A et.al. (2017). Vascularized Tissue-Engineered Model for Studying Drug Resistance in Neuroblastoma. Theranostics 7:4099-4117.
608Jongen JMJ et.al. (2017). Downregulation of DNA repair proteins and increased DNA damage in hypoxic colon cancer cells is a therapeutically exploitable vulnerability. Oncotarget 8:86296-86311.
607Bustos V et.al. (2017). GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions. Oncotarget 8:84258-84275.
606Paul P et.al. (2017). Elevated TIMP-1 expression is associated with a prometastatic phenotype, disease relapse, and poor survival in neuroblastoma. Oncotarget 8:82609-82620.
605Hurst CD et.al. (2017). Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency. Cancer Cell 32:701-715.e7.
604Savci-Heijink CD et.al. (2017). Association between gene expression profile of the primary tumor and chemotherapy response of metastatic breast cancer. BMC Cancer 17:755.
603Chang W et.al. (2017). Immature colon carcinoma transcript-1 promotes cell growth of hepatocellular carcinoma via facilitating cell cycle progression and apoptosis resistance. Oncol Rep 38:3489-3496.
602Zhang D et.al. (2017). Down-regulation of CHERP inhibits neuroblastoma cell proliferation and induces apoptosis through ER stress induction. Oncotarget 8:80956-80970.
601Mir SE et.al. (2017). Trimethylation of H3K27 during human cerebellar development in relation to medulloblastoma. Oncotarget 8:78978-78988.
600Zhou G et.al. (2017). Homeobox B4 inhibits breast cancer cell migration by directly binding to StAR-related lipid transfer domain protein 13. Oncol Lett 14:4625-4632.
599Hong L et.al. (2017). Downregulation of miR-16 via URGCP pathway contributes to glioma growth. Sci Rep 7:13470.
598Yang Z et.al. (2017). Reprogramming of stromal fibroblasts by SNAI2 contributes to tumor desmoplasia and ovarian cancer progression. Mol Cancer 16:163.
597Xu L et.al. (2017). YBX1 promotes tumor growth by elevating glycolysis in human bladder cancer. Oncotarget 8:65946-65956.
596Delloye-Bourgeois C et.al. (2017). Microenvironment-Driven Shift of Cohesion/Detachment Balance within Tumors Induces a Switch toward Metastasis in Neuroblastoma. Cancer Cell 32:427-443.e8.
595Tao Y et.al. (2017). miR-205 regulation of ICT1 has an oncogenic potential via promoting the migration and invasion of gastric cancer cells. Biomed Pharmacother 96:191-197.
594Mahmud H et.al. (2017). Peptide microarray profiling identifies phospholipase C gamma 1 (PLC-gamma1) as a potential target for t(8;21) AML. Oncotarget 8:67344-67354.
593Lobbardi R et.al. (2017). TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia. Cancer Discov 7:1336-1353.
592van Attekum MHA et.al. (2017). CD40 signaling instructs chronic lymphocytic leukemia cells to attract monocytes via the CCR2 axis. Haematologica 102:2069-2076.
591Vardon A et.al. (2017). Arginine auxotrophic gene signature in paediatric sarcomas and brain tumours provides a viable target for arginine depletion therapies. Oncotarget 8:63506-63517.
590Kumar SS et.al. (2017). BMI-1 is a potential therapeutic target in diffuse intrinsic pontine glioma. Oncotarget 8:62962-62975.
589Russo R et.al. (2017). Kinome expression profiling of human neuroblastoma tumors identifies potential drug targets for ultra high-risk patients. Carcinogenesis 38:1011-1020.
588Kumar SA et.al. (2017). Pathological and prognostic role of mdig in pancreatic cancer. Genes Cancer 8:650-658.
587Meel MH et.al. (2017). Culture methods of diffuse intrinsic pontine glioma cells determine response to targeted therapies. Exp Cell Res 360:397-403.
586Yue C et.al. (2017). High expression of Brutons tyrosine kinase (BTK) is required for EGFR-induced NF-kappaB activation and predicts poor prognosis in human glioma. J Exp Clin Cancer Res 36:132.
585Wu X et.al. (2017). Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor. Nat Cell Biol 19:1226-1236.
584Guadagno E et.al. (2017). PATZ1 is a new prognostic marker of glioblastoma associated with the stem-like phenotype and enriched in the proneural subtype. Oncotarget 8:59282-59300.
583Canovas V et.al. (2017). Prostate Tumor Overexpressed-1 (PTOV1) promotes docetaxel-resistance and survival of castration resistant prostate cancer cells. Oncotarget 8:59165-59180.
582Jimenez-Garcia MP et.al. (2017). Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus. Oncotarget 8:58872-58886.
581Wang S et.al. (2017). BMPR2 promotes invasion and metastasis via the RhoA-ROCK-LIMK2 pathway in human osteosarcoma cells. Oncotarget 8:58625-58641.
580Villa E et.al. (2017). Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells. Cell Rep 20:2846-2859.
579Li Y et.al. (2017). Genomic analysis-integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway. Oncotarget 8:56684-56697.
578Bosse KR et.al. (2017). Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma. Cancer Cell 32:295-309.e12.
577Erdreich-Epstein A et.al. (2017). Association of high microvessel alphavbeta3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126. Oncotarget 8:52193-52210.
576Strobel T et.al. (2017). Ape1 guides DNA repair pathway choice that is associated with drug tolerance in glioblastoma. Sci Rep 7:9674.
575Ryl T et.al. (2017). Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug. Cell Syst 5:237-250.e8.
574Bingel C et.al. (2017). Three-dimensional tumor cell growth stimulates autophagic flux and recapitulates chemotherapy resistance. Cell Death Dis 8:e3013.
573Jeanne A et.al. (2017). Lumican delays melanoma growth in mice and drives tumor molecular assembly as well as response to matrix-targeted TAX2 therapeutic peptide. Sci Rep 7:7700.
572Li Y et.al. (2017). CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells. EMBO Rep 18:1646-1659.
571Watanabe Y et.al. (2017). ZAR1 knockdown promotes the differentiation of human neuroblastoma cells by suppression of MYCN expression. Med Oncol 34:158.
570Ambrosio S et.al. (2017). Lysine-specific demethylase LSD1 regulates autophagy in neuroblastoma through SESN2-dependent pathway. Oncogene 36:6701-6711.
569Calero R et.al. (2017). Synergistic anti-tumor effect of 17AAG with the PI3K/mTOR inhibitor NVP-BEZ235 on human melanoma. Cancer Lett 406:1-11.
568Roy R et.al. (2017). ADAM12 Is a Novel Regulator of Tumor Angiogenesis via STAT3 Signaling. Mol Cancer Res 15:1608-1622.
567Xie Y et.al. (2017). Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma. Gastroenterology 153:1429-1443.e5.
566Bloemendaal FM et.al. (2017). Anti-Tumor Necrosis Factor With a Glyco-Engineered Fc-Region Has Increased Efficacy in Mice With Colitis. Gastroenterology 153:1351-1362.e4.
565Satterfield L et.al. (2017). miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma. Int J Cancer 141:2062-2075.
564Vellinga TT et.al. (2017). Lymphangiogenic Gene Expression Is Associated With Lymph Node Recurrence and Poor Prognosis After Partial Hepatectomy for Colorectal Liver Metastasis. Ann Surg 266:765-771.
563Li N et.al. (2017). Therapeutically targeting glypican-2 via single-domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastoma. Proc Natl Acad Sci U S A 114:E6623-E6631.
562Dyberg C et.al. (2017). Rho-associated kinase is a therapeutic target in neuroblastoma. Proc Natl Acad Sci U S A 114:E6603-E6612.
561Brauss TF et.al. (2017). The RNA-binding protein HuR inhibits expression of CCL5 and limits recruitment of macrophages into tumors. Mol Carcinog 56:2620-2629.
560Northcott PA et.al. (2017). The whole-genome landscape of medulloblastoma subtypes. Nature 547:311-317.
559Wang Y et.al. (2017). Long non-coding RNA CASC2 suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells through CASC2/miR-367/FBXW7 axis. Mol Cancer 16:123.
558Park NI et.al. (2017). ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells. Cell Stem Cell 21:209-224.e7.
557Westerlund I et.al. (2017). Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2alpha to tumor suppression. Proc Natl Acad Sci U S A 114:E6137-E6146.
556Friedrich C et.al. (2017). Tropomyosin receptor kinase C (TrkC) expression in medulloblastoma: relation to the molecular subgroups and impact on treatment response. Childs Nerv Syst 33:1463-1471.
555Trumpi K et.al. (2017). Neoadjuvant chemotherapy affects molecular classification of colorectal tumors. Oncogenesis 6:e357.
554Neto M et.al. (2017). Nuclear receptors connect progenitor transcription factors to cell cycle control. Sci Rep 7:4845.
553Sun Y et.al. (2017). Upregulation of LYAR induces neuroblastoma cell proliferation and survival. Cell Death Differ 24:1645-1654.
552Ma X et.al. (2017). CXCR4 expression varies significantly among different subtypes of glioblastoma multiforme (GBM) and its low expression or hypermethylation might predict favorable overall survival. Expert Rev Neurother 17:941-946.
551Yang J et.al. (2017). Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox. Cancer Res 77:4626-4638.
550Layer JP et.al. (2017). Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression. Oncoimmunology 6:e1320626.
549Lennicke C et.al. (2017). Modulation of MHC class I surface expression in B16F10 melanoma cells by methylseleninic acid. Oncoimmunology 6:e1259049.
548Capasso M et.al. (2017). The functional variant rs34330 of CDKN1B is associated with risk of neuroblastoma. J Cell Mol Med 21:3224-3230.
547van Groningen T et.al. (2017). Neuroblastoma is composed of two super-enhancer-associated differentiation states. Nat Genet 49:1261-1266.
546Conduit SE et.al. (2017). A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma. Oncogene 36:5969-5984.
545Fell SM et.al. (2017). Neuroblast differentiation during development and in neuroblastoma requires KIF1Bbeta-mediated transport of TRKA. Genes Dev 31:1036-1053.
544Rodriguez-Hernandez G et.al. (2017). Infection Exposure Promotes ETV6-RUNX1 Precursor B-cell Leukemia via Impaired H3K4 Demethylases. Cancer Res 77:4365-4377.
543Chikaraishi K et.al. (2017). CFC1 is a cancer stemness-regulating factor in neuroblastoma. Oncotarget 8:45046-45059.
542de Rooij B et.al. (2017). Acute lymphoblastic leukemia cells create a leukemic niche without affecting the CXCR4/CXCL12 axis. Haematologica 102:e389-e393.
541Mu P et.al. (2017). A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-kappaB degradation and cell growth suppression in neuroblastoma. Oncogene 36:5745-5756.
540Su YK et.al. (2017). Antrodia cinnamomea sensitizes radio-/chemo-therapy of cancer stem-like cells by modulating microRNA expression. J Ethnopharmacol 207:47-56.
539Gao S et.al. (2017). Overexpression of RASD1 inhibits glioma cell migration/invasion and inactivates the AKT/mTOR signaling pathway. Sci Rep 7:3202.
538Dong X et.al. (2017). RSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt pathway. Cancer Lett 402:153-165.
537Seifert A et.al. (2017). Tightly controlled MRTF-A activity regulates epithelial differentiation during formation of mammary acini. Breast Cancer Res 19:68.
536Delaidelli A et.al. (2017). MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation. Cell Death Differ 24:1564-1576.
535Maciaczyk D et.al. (2017). CBF1 is clinically prognostic and serves as a target to block cellular invasion and chemoresistance of EMT-like glioblastoma cells. Br J Cancer 117:102-112.
534Liu H et.al. (2017). MELK and EZH2 Cooperate to Regulate Medulloblastoma Cancer Stem-like Cell Proliferation and Differentiation. Mol Cancer Res 15:1275-1286.
533Stiegelbauer V et.al. (2017). miR-196b-5p Regulates Colorectal Cancer Cell Migration and Metastases through Interaction with HOXB7 and GALNT5. Clin Cancer Res 23:5255-5266.
532Kawauchi D et.al. (2017). Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells. Oncogene 36:5231-5242.
531Henssen AG et.al. (2017). PGBD5 promotes site-specific oncogenic mutations in human tumors. Nat Genet 49:1005-1014.
530Veenstra VL et.al. (2017). Stromal SPOCK1 supports invasive pancreatic cancer growth. Mol Oncol 11:1050-1064.
529Schmidt C et.al. (2017). Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients. Neuro Oncol 19:1607-1617.
528Silginer M et.al. (2017). Autocrine activation of the IFN signaling pathway may promote immune escape in glioblastoma. Neuro Oncol 19:1338-1349.
527Chen NP et.al. (2017). Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm. Proc Natl Acad Sci U S A 114:5201-5206.
526Roy A et.al. (2017). Serglycin as a potential biomarker for glioma: association of serglycin expression, extent of mast cell recruitment and glioblastoma progression. Oncotarget 8:24815-24827.
525Duong C et.al. (2017). Novel targeted therapy for neuroblastoma: silencing the MXD3 gene using siRNA. Pediatr Res 82:527-535.
524Sanden E et.al. (2017). Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation. Sci Rep 7:46366.
523Yurugi H et.al. (2017). Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours. Oncogene 36:4778-4789.
522Kanska J et.al. (2017). Glucose deprivation elicits phenotypic plasticity via ZEB1-mediated expression of NNMT. Oncotarget 8:26200-26220.
521Pezzolo A et.al. (2017). Constitutional 3p26.3 terminal microdeletion in an adolescent with neuroblastoma. Cancer Biol Ther 18:285-289.
520Xu J et.al. (2017). PID1 increases chemotherapy-induced apoptosis in medulloblastoma and glioblastoma cells in a manner that involves NFkappaB. Sci Rep 7:835.
519Colicchia V et.al. (2017). PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma. Oncogene 36:4682-4691.
518Deivendran S et.al. (2017). Metastasis-associated protein 1 is an upstream regulator of DNMT3a and stimulator of insulin-growth factor binding protein-3 in breast cancer. Sci Rep 7:44225.
517Thompson EM et.al. (2017). The role of angiogenesis in Group 3 medulloblastoma pathogenesis and survival. Neuro Oncol 19:1217-1227.
516Seystahl K et.al. (2017). Biological Role and Therapeutic Targeting of TGF-beta3 in Glioblastoma. Mol Cancer Ther 16:1177-1186.
515Rapetti-Mauss R et.al. (2017). Bidirectional KCNQ1:beta-catenin interaction drives colorectal cancer cell differentiation. Proc Natl Acad Sci U S A 114:4159-4164.
514Pang Z et.al. (2017). Expressions of insulin-like growth factor receptor-1 and cezanne-1 in lung adenocarcinoma. Med Oncol 34:78.
513Bhatia S et.al. (2017). Combined EphB2 receptor knockdown with radiation decreases cell viability and invasion in medulloblastoma. Cancer Cell Int 17:41.
512Kaluski S et.al. (2017). Neuroprotective Functions for the Histone Deacetylase SIRT6. Cell Rep 18:3052-3062.
511Dewi DL et.al. (2017). Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer. Oncoimmunology 6:e1274477.
510Zhang S et.al. (2017). m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. Cancer Cell 31:591-606.e6.
509Wang K et.al. (2017). The noncoding RNA linc-ADAMTS5 cooperates with RREB1 to protect from intervertebral disc degeneration through inhibiting ADAMTS5 expression. Clin Sci (Lond) 131:965-979.
508Guo P et.al. (2017). A quantitative method for screening and identifying molecular targets for nanomedicine. J Control Release 263:57-67.
507Zhang X et.al. (2017). Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation. Cell Rep 18:2932-2942.
506Thewes V et.al. (2017). The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERalpha-negative breast cancer. Oncogene 36:4124-4134.
505Raats DA et.al. (2017). CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage. Cell Death Dis 8:e2669.
504Zhang D et.al. (2017). ALG2 regulates glioblastoma cell proliferation, migration and tumorigenicity. Biochem Biophys Res Commun 486:300-306.
503Gholamin S et.al. (2017). Disrupting the CD47-SIRPalpha anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors. Sci Transl Med 9:.
502Sewing ACP et.al. (2017). Preclinical evaluation of convection-enhanced delivery of liposomal doxorubicin to treat pediatric diffuse intrinsic pontine glioma and thalamic high-grade glioma. J Neurosurg Pediatr 19:518-530.
501Zhou F et.al. (2017). Jab1/Csn5-Thioredoxin Signaling in Relapsed Acute Monocytic Leukemia under Oxidative Stress. Clin Cancer Res 23:4450-4461.
500Tao T et.al. (2017). The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma. Oncogene 36:3852-3867.
499Abbasi MR et.al. (2017). Impact of Disseminated Neuroblastoma Cells on the Identification of the Relapse-Seeding Clone. Clin Cancer Res 23:4224-4232.
498An T et.al. (2017). USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth. Biochem Pharmacol 131:29-39.
497Bate-Eya LT et.al. (2017). Enhancer of zeste homologue 2 plays an important role in neuroblastoma cell survival independent of its histone methyltransferase activity. Eur J Cancer 75:63-72.
496Wong M et.al. (2017). The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription. Cancer Res 77:2522-2533.
495Tu Y et.al. (2017). Smoothened is a poor prognosis factor and a potential therapeutic target in glioma. Sci Rep 7:42630.
494Bi G et.al. (2017). PRRT2 inhibits the proliferation of glioma cells by modulating unfolded protein response pathway. Biochem Biophys Res Commun 485:454-460.
493Cheng F et.al. (2017). RNA-Binding Protein Dnd1 Promotes Breast Cancer Apoptosis by Stabilizing the Bim mRNA in a miR-221 Binding Site. Biomed Res Int 2017:9596152.
492Duffy DJ et.al. (2017). Retinoic acid and TGF-beta signalling cooperate to overcome MYCN-induced retinoid resistance. Genome Med 9:15.
491Gaviglio AL et.al. (2017). Heparin-binding epidermal growth factor-like growth factor promotes neuroblastoma differentiation. FASEB J 31:1903-1915.
490Lin C et.al. (2017). Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer. BMC Cancer 17:113.
489Kakumu T et.al. (2017). Identification of proteasomal catalytic subunit PSMA6 as a therapeutic target for lung cancer. Cancer Sci 108:732-743.
488Garcia-Heredia JM et.al. (2017). The Cargo Protein MAP17 (PDZK1IP1) Regulates the Cancer Stem Cell Pool Activating the Notch Pathway by Abducting NUMB. Clin Cancer Res 23:3871-3883.
487Chanakira A et.al. (2017). Tissue factor-factor VIIa complex triggers protease activated receptor 2-dependent growth factor release and migration in ovarian cancer. Gynecol Oncol 145:167-175.
486Wang D et.al. (2017). Aberrant activation of hedgehog signaling promotes cell proliferation via the transcriptional activation of forkhead Box M1 in colorectal cancer cells. J Exp Clin Cancer Res 36:23.
485Fancello L et.al. (2017). The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types. Oncotarget 8:14462-14478.
484Chung ST et.al. (2017). Osteoprotegerin mediates tumor-promoting effects of Interleukin-1beta in breast cancer cells. Mol Cancer 16:27.
483Carpi S et.al. (2017). Tumor-promoting effects of cannabinoid receptor type 1 in human melanoma cells. Toxicol In Vitro 40:272-279.
482Xu M et.al. (2017). Interactions between interleukin-6 and myeloid-derived suppressor cells drive the chemoresistant phenotype of hepatocellular cancer. Exp Cell Res 351:142-149.
481Jeibmann A et.al. (2017). SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors. J Neurooncol 131:477-484.
480Veschi V et.al. (2017). Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma. Cancer Cell 31:50-63.
479Baglio SR et.al. (2017). Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression. Clin Cancer Res 23:3721-3733.
478Busiello T et.al. (2017). Role of ZNF224 in cell growth and chemoresistance of chronic lymphocitic leukemia. Hum Mol Genet 26:344-353.
477Villanueva AA et.al. (2017). The Netrin-4/ Neogenin-1 axis promotes neuroblastoma cell survival and migration. Oncotarget 8:9767-9782.
476El-Habr EA et.al. (2017). A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma. Acta Neuropathol 133:645-660.
475Jung M et.al. (2017). A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers. Cancer Res 77:971-981.
474Hofman IJF et.al. (2017). RPL5 on 1p22.1 is recurrently deleted in multiple myeloma and its expression is linked to bortezomib response. Leukemia 31:1706-1714.
473van Keimpema M et.al. (2017). The small FOXP1 isoform predominantly expressed in activated B cell-like diffuse large B-cell lymphoma and full-length FOXP1 exert similar oncogenic and transcriptional activity in human B cells. Haematologica 102:573-583.
472Bieerkehazhi S et.al. (2017). Novel Src/Abl tyrosine kinase inhibitor bosutinib suppresses neuroblastoma growth via inhibiting Src/Abl signaling. Oncotarget 8:1469-1480.
471Mao X et.al. (2017). Novel multi-targeted ErbB family inhibitor afatinib blocks EGF-induced signaling and induces apoptosis in neuroblastoma. Oncotarget 8:1555-1568.
470Seong BK et.al. (2017). A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis. Cancer Res 77:696-706.
469Ambrosio S et.al. (2017). LSD1 mediates MYCN control of epithelial-mesenchymal transition through silencing of metastatic suppressor NDRG1 gene. Oncotarget 8:3854-3869.
468Charlet J et.al. (2017). Genome-wide DNA methylation analysis identifies MEGF10 as a novel epigenetically repressed candidate tumor suppressor gene in neuroblastoma. Mol Carcinog 56:1290-1301.
467Zhang H et.al. (2017). STARD13 promotes hepatocellular carcinoma apoptosis by acting as a ceRNA for Fas. Biotechnol Lett 39:207-217.
466Jeanne A et.al. (2017). Thrombospondin-targeting TAX2 peptide impairs tumor growth in preclinical mouse models of childhood neuroblastoma. Pediatr Res 81:480-488.
465McManus M et.al. (2017). Hes4: A potential prognostic biomarker for newly diagnosed patients with high-grade osteosarcoma. Pediatr Blood Cancer 64:.
464Xiong N et.al. (2017). Involvement of caveolin-1 in low shear stress-induced breast cancer cell motility and adhesion: Roles of FAK/Src and ROCK/p-MLC pathways. Biochim Biophys Acta Mol Cell Res 1864:12-22.
463Jan A et.al. (2017). eEF2K inhibition blocks Abeta42 neurotoxicity by promoting an NRF2 antioxidant response. Acta Neuropathol 133:101-119.
462Borovski T et.al. (2017). Inhibition of RAF1 kinase activity restores apicobasal polarity and impairs tumour growth in human colorectal cancer. Gut 66:1106-1115.
461Hou J et.al. (2017). CSN6 controls the proliferation and metastasis of glioblastoma by CHIP-mediated degradation of EGFR. Oncogene 36:1134-1144.
460Pan Y et.al. (2017). Stat3 contributes to cancer progression by regulating Jab1/Csn5 expression. Oncogene 36:1069-1079.
459Huang MY et.al. (2017). MINA controls proliferation and tumorigenesis of glioblastoma by epigenetically regulating cyclins and CDKs via H3K9me3 demethylation. Oncogene 36:387-396.
458Li C et.al. (2017). Elevated AQP1 Expression Is Associated With Unfavorable Oncologic Outcome in Patients With Hilar Cholangiocarcinoma. Technol Cancer Res Treat 16:421-427.
2016 (n=142)
457Hansen JN et.al. (2016). EYA1 expression and subcellular localization in neuroblastoma and its association with prognostic markers. J Cancer Res Ther (Manch) 4:11-18.
456Cangelosi D et.al. (2016). Artificial neural network classifier predicts neuroblastoma patients outcome. BMC Bioinformatics 17:347.
455Eissler N et.al. (2016). Regulation of myeloid cells by activated T cells determines the efficacy of PD-1 blockade. Oncoimmunology 5:e1232222.
454Kasim M et.al. (2016). Achaete-Scute Homolog 1 Expression Controls Cellular Differentiation of Neuroblastoma. Front Mol Neurosci 9:156.
453Salazar BM et.al. (2016). Neuroblastoma, a Paradigm for Big Data Science in Pediatric Oncology. Int J Mol Sci 18:.
452Mooberry LK et.al. (2016). Targeting the SR-B1 Receptor as a Gateway for Cancer Therapy and Imaging. Front Pharmacol 7:466.
451Chen Z et.al. (2016). Wip1 inhibitor GSK2830371 inhibits neuroblastoma growth by inducing Chk2/p53-mediated apoptosis. Sci Rep 6:38011.
450Ma W et.al. (2016). Human Papillomavirus Downregulates the Expression of IFITM1 and RIPK3 to Escape from IFNgamma Front Immunol 7:496.
449Jimenez-Garcia MP et.al. (2016). The role of PIM1/PIM2 kinases in tumors of the male reproductive system. Sci Rep 6:38079.
448Vella S et.al. (2016). Targeting CDKs with Roscovitine Increases Sensitivity to DNA Damaging Drugs of Human Osteosarcoma Cells. PLoS One 11:e0166233.
447Gao S et.al. (2016). Low Expression of CAPON in Glioma Contributes to Cell Proliferation via the Akt Signaling Pathway. Int J Mol Sci 17:.
446den Uil SH et.al. (2016). Loss of KCNQ1 expression in stage II and stage III colon cancer is a strong prognostic factor for disease recurrence. Br J Cancer 115:1565-1574.
445Qiu X et.al. (2016). Overexpression of FZD7 promotes glioma cell proliferation by upregulating TAZ. Oncotarget 7:85987-85999.
444Augustin I et.al. (2016). Immune cell recruitment in teratomas is impaired by increased Wnt secretion. Stem Cell Res 17:607-615.
443Stankovic ND et.al. (2016). No role of IFITM3 in brain tumor formation in vivo. Oncotarget 7:86388-86405.
442Maugeri M et.al. (2016). Altered expression of miRNAs and methylation of their promoters are correlated in neuroblastoma. Oncotarget 7:83330-83341.
441Sulzmaier FJ et.al. (2016). RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics. Oncotarget 7:79869-79884.
440Bassett EA et.al. (2016). Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation. Elife 5:.
439Techavichit P et.al. (2016). Secreted Frizzled-Related Protein 2 (sFRP2) promotes osteosarcoma invasion and metastatic potential. BMC Cancer 16:869.
438Trypsteen W et.al. (2016). Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay. Sci Rep 6:36111.
437Xiao D et.al. (2016). Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival. Mol Cell 64:493-506.
436Zhao Z et.al. (2016). A combined gene expression and functional study reveals the crosstalk between N-Myc and differentiation-inducing microRNAs in neuroblastoma cells. Oncotarget 7:79372-79387.
435Liu PY et.al. (2016). NCYM is upregulated by lncUSMycN and modulates N-Myc expression. Int J Oncol 49:2464-2470.
434Liu X et.al. (2016). CRM1/XPO1 is associated with clinical outcome in glioma and represents a therapeutic target by perturbing multiple core pathways. J Hematol Oncol 9:108.
433Flahaut M et.al. (2016). Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma. BMC Cancer 16:781.
432Zhang H et.al. (2016). Expression and significance of Hippo/YAP signaling in glioma progression. Tumour Biol :.
431Liu M et.al. (2016). Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells. Cell Rep 17:609-623.
430Matas-Rico E et.al. (2016). Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome. Cancer Cell 30:548-562.
429Catena V et.al. (2016). Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells. Oncotarget 7:70546-70558.
428Brand A et.al. (2016). LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells. Cell Metab 24:657-671.
427Henrich KO et.al. (2016). Integrative Genome-Scale Analysis Identifies Epigenetic Mechanisms of Transcriptional Deregulation in Unfavorable Neuroblastomas. Cancer Res 76:5523-37.
426Wang LY et.al. (2016). KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis. Cell Rep 16:3016-3027.
425Suryo Rahmanto A et.al. (2016). FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma. EMBO J 35:2192-2212.
424Tavana O et.al. (2016). HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma. Nat Med 22:1180-1186.
423Garcia-Heredia JM et.al. (2016). Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy. Oncotarget 7:63611-63628.
422Ubink I et.al. (2016). A potential role for CCN2/CTGF in aggressive colorectal cancer. J Cell Commun Signal 10:223-227.
421Jia D et.al. (2016). A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets. Cancer Lett 382:203-214.
420Cimmino F et.al. (2016). Proteomic Alterations in Response to Hypoxia Inducible Factor 2alpha in Normoxic Neuroblastoma Cells. J Proteome Res 15:3643-3655.
419Qu H et.al. (2016). Smad4 suppresses the tumorigenesis and aggressiveness of neuroblastoma through repressing the expression of heparanase. Sci Rep 6:32628.
418Chakrabarti A et.al. (2016). Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases. Future Med Chem 8:1609-34.
417Fabian J et.al. (2016). MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma. Oncotarget 7:66344-66359.
416Eberhardt A et.al. (2016). Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma. Oncotarget 7:63629-63639.
415Wang Z et.al. (2016). CD151-mediated adhesion is crucial to osteosarcoma pulmonary metastasis. Oncotarget 7:60623-60638.
414Murakami-Tonami Y et.al. (2016). SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells. Sci Rep 6:31615.
413Montalban Del Barrio I et.al. (2016). Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages J Immunother Cancer 4:49.
412Duffy DJ et.al. (2016). Wnt signalling is a bi-directional vulnerability of cancer cells. Oncotarget 7:60310-60331.
411Buren S et.al. (2016). Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms. Cancer Cell 30:290-307.
410Franco R et.al. (2016). PATZ1 expression correlates positively with BAX and negatively with BCL6 and survival in human diffuse large B cell lymphomas. Oncotarget 7:59158-59172.
409Worst BC et.al. (2016). Next-generation personalised medicine for high-risk paediatric cancer patients Eur J Cancer 65:91-101.
408Kritikou JS et.al. (2016). IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo. Sci Rep 6:30636.
407Lu F et.al. (2016). Downregulation of CREB Promotes Cell Proliferation by Mediating G1/S Phase Transition in Hodgkin Lymphoma. Oncol Res 24:171-9.
406Prince EW et.al. (2016). Checkpoint kinase 1 expression is an adverse prognostic marker and therapeutic target in MYC-driven medulloblastoma. Oncotarget 7:53881-53894.
405Snapkov I et.al. (2016). The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis. BMC Cancer 16:490.
404Thimsen V et.al. (2016). EpCAM (CD326) is differentially expressed in craniopharyngioma subtypes and Rathkes cleft cysts. Sci Rep 6:29731.
403Madan M et.al. (2016). ATP13A3 and caveolin-1 as potential biomarkers for difluoromethylornithine-based therapies in pancreatic cancers. Am J Cancer Res 6:1231-52.
402van Engen CE et.al. (2016). CYP4F2 affects phenotypic outcome in adrenoleukodystrophy by modulating the clearance of very long-chain fatty acids. Biochim Biophys Acta 1862:1861-70.
401Somarelli JA et.al. (2016). Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2. Mol Cell Biol 36:2503-13.
400Middelbeek J et.al. (2016). The TRPM7 interactome defines a cytoskeletal complex linked to neuroblastoma progression. Eur J Cell Biol 95:465-474.
399Powers JT et.al. (2016). Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma. Nature 535:246-51.
398Taminiau A et.al. (2016). HOXA1 binds RBCK1/HOIL-1 and TRAF2 and modulates the TNF/NF-kappaB pathway in a transcription-independent manner. Nucleic Acids Res 44:7331-49.
397Chen Z et.al. (2016). Multiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activity. Sci Rep 6:29090.
396Sheikh A et.al. (2016). Unfavorable neuroblastoma prognostic factor NLRR2 inhibits cell differentiation by transcriptional induction through JNK pathway. Cancer Sci 107:1223-32.
395Gramatzki D et.al. (2016). Interleukin-33 in human gliomas: Expression and prognostic significance. Oncol Lett 12:445-452.
394Wang Y et.al. (2016). TP53INP1 3-UTR functions as a ceRNA in repressing the metastasis of glioma cells by regulating miRNA activity. Biotechnol Lett 38:1699-707.
393Jansen MH et.al. (2016). Bevacizumab Targeting Diffuse Intrinsic Pontine Glioma: Results of 89Zr-Bevacizumab PET Imaging in Brain Tumor Models. Mol Cancer Ther 15:2166-74.
392Agnihotri S et.al. (2016). PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma. Cancer Res 76:4708-19.
391Joosten M et.al. (2016). A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma. Mol Oncol 10:1232-44.
390Shackleford GM et.al. (2016). BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma. PLoS One 11:e0156907.
389Phillips E et.al. (2016). Targeting atypical protein kinase C iota reduces viability in glioblastoma stem-like cells via a notch signaling mechanism. Int J Cancer 139:1776-87.
388Blaeschke F et.al. (2016). Human HLA-A*02:01/CHM1+ allo-restricted T cell receptor transgenic CD8+ T cells specifically inhibit Ewing sarcoma growth in vitro and in vivo. Oncotarget 7:43267-43280.
387Villasante A et.al. (2016). Recapitulating the Size and Cargo of Tumor Exosomes in a Tissue-Engineered Model. Theranostics 6:1119-30.
386Qu H et.al. (2016). microRNA-558 facilitates the expression of hypoxia-inducible factor 2 alpha through binding to 5-untranslated region in neuroblastoma. Oncotarget 7:40657-40673.
385Garcia-Ramirez I et.al. (2016). Could Vitamin D Analogues Be Used to Target Leukemia Stem Cells? Int J Mol Sci 17:.
384Han X et.al. (2016). Microfluidic Cell Deformability Assay for Rapid and Efficient Kinase Screening with the CRISPR-Cas9 System. Angew Chem Int Ed Engl 55:8561-5.
383Yogev O et.al. (2016). p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance. Cancer Res 76:3025-35.
382Formicola D et.al. (2016). An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma. J Transl Med 14:142.
381Faouzi M et.al. (2016). Functional cooperation between KCa3.1 and TRPC1 channels in human breast cancer: Role in cell proliferation and patient prognosis. Oncotarget 7:36419-36435.
380Fletcher JI et.al. (2016). ABC transporters as mediators of drug resistance and contributors to cancer cell biology. Drug Resist Updat 26:1-9.
379Folgiero V et.al. (2016). IDO1 involvement in mTOR pathway: a molecular mechanism of resistance to mTOR targeting in medulloblastoma. Oncotarget 7:52900-52911.
378Hsu CL et.al. (2016). Unveiling MYCN regulatory networks in neuroblastoma via integrative analysis of heterogeneous genomics data. Oncotarget 7:36293-36310.
377Yang R et.al. (2016). The Hippo transducer TAZ promotes cell proliferation and tumor formation of glioblastoma cells through EGFR pathway. Oncotarget 7:36255-36265.
376Berlanga P et.al. (2016). miR-200c and phospho-AKT as prognostic factors and mediators of osteosarcoma progression and lung metastasis. Mol Oncol 10:1043-53.
375Weeks A et.al. (2016). Epithelial Cell Transforming 2 and Aurora Kinase B Modulate Formation of Stress Granule-Containing Transcripts from Diverse Cellular Pathways in Astrocytoma Cells. Am J Pathol 186:1674-87.
374Fuady JH et.al. (2016). Estrogen-dependent downregulation of hypoxia-inducible factor (HIF)-2alpha in invasive breast cancer cells. Oncotarget 7:31153-65.
373Bate-Eya LT et.al. (2016). High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition. Oncotarget 7:27946-58.
372Kloepper J et.al. (2016). Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival. Proc Natl Acad Sci U S A 113:4476-81.
371Cimmino F et.al. (2016). CD55 is a HIF-2alpha marker with anti-adhesive and pro-invading properties in neuroblastoma. Oncogenesis 5:e212.
370Dyberg C et.al. (2016). Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma. BMC Cancer 16:259.
369Woodfield SE et.al. (2016). Neuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B. Genes Cancer 7:13-26.
368Lasorsa VA et.al. (2016). Exome and deep sequencing of clinically aggressive neuroblastoma reveal somatic mutations that affect key pathways involved in cancer progression. Oncotarget 7:21840-52.
367Szabo E et.al. (2016). Autocrine VEGFR1 and VEGFR2 signaling promotes survival in human glioblastoma models in vitro and in vivo. Neuro Oncol 18:1242-52.
366Vellinga TT et.al. (2016). Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion. Oncogene 35:5263-5271.
365Agarwal S et.al. (2016). Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma. Oncotarget 7:24018-26.
364Casey SC et.al. (2016). MYC regulates the antitumor immune response through CD47 and PD-L1. Science 352:227-31.
363Savci-Heijink CD et.al. (2016). A novel gene expression signature for bone metastasis in breast carcinomas. Breast Cancer Res Treat 156:249-59.
362Aykul S et.al. (2016). Transforming Growth Factor-beta Family Ligands Can Function as Antagonists by Competing for Type II Receptor Binding. J Biol Chem 291:10792-804.
361Mao Y et.al. (2016). Targeting Suppressive Myeloid Cells Potentiates Checkpoint Inhibitors to Control Spontaneous Neuroblastoma. Clin Cancer Res 22:3849-59.
360Dondero A et.al. (2016). PD-L1 expression in metastatic neuroblastoma as an additional mechanism for limiting immune surveillance. Oncoimmunology 5:e1064578.
359Lee D et.al. (2016). Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy. J Clin Invest 126:1300-10.
358Holsken A et.al. (2016). Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles. Acta Neuropathol Commun 4:20.
357Woodfield SE et.al. (2016). Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression. BMC Cancer 16:172.
356Johann PD et.al. (2016). Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes. Cancer Cell 29:379-393.
355Panosyan EH et.al. (2016). Clinical aggressiveness of malignant gliomas is linked to augmented metabolism of amino acids. J Neurooncol 128:57-66.
354Sturm D et.al. (2016). New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs. Cell 164:1060-1072.
353Bijnsdorp IV et.al. (2016). miR-129-3p controls centrosome number in metastatic prostate cancer cells by repressing CP110. Oncotarget 7:16676-87.
352Busch B et.al. (2016). The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family. Nucleic Acids Res 44:3845-64.
351Yang L et.al. (2016). PHOX2B Is Associated with Neuroblastoma Cell Differentiation. Cancer Biother Radiopharm 31:44-51.
350Huang S et.al. (2016). Impact of S100A4 Expression on Clinicopathological Characteristics and Prognosis in Pancreatic Cancer: A Meta-Analysis. Dis Markers 2016:8137378.
349Kim PY et.al. (2016). High TDP43 expression is required for TRIM16-induced inhibition of cancer cell growth and correlated with good prognosis of neuroblastoma and breast cancer patients. Cancer Lett 374:315-23.
348Stojcheva N et.al. (2016). MicroRNA-138 promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM. Oncotarget 7:12937-50.
347Abbou S et.al. (2016). Polo-like Kinase Inhibitor Volasertib Exhibits Antitumor Activity and Synergy with Vincristine in Pediatric Malignancies. Anticancer Res 36:599-609.
346Tetteh PW et.al. (2016). Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters. Cell Stem Cell 18:203-13.
345Soriano A et.al. (2016). MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes. Oncotarget 7:9271-87.
344Li S et.al. (2016). The 1p36 Tumor Suppressor KIF 1Bbeta Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis. Dev Cell 36:164-78.
343Olsson M et.al. (2016). Genome-wide methylation profiling identifies novel methylated genes in neuroblastoma tumors. Epigenetics 11:74-84.
342Morrissy AS et.al. (2016). Divergent clonal selection dominates medulloblastoma at recurrence. Nature 529:351-7.
341Sanchez-Osuna M et.al. (2016). An intrinsic DFF40/CAD endonuclease deficiency impairs oligonucleosomal DNA hydrolysis during caspase-dependent cell death: a common trait in human glioblastoma cells. Neuro Oncol 18:950-61.
340Than BL et.al. (2016). CFTR is a tumor suppressor gene in murine and human intestinal cancer. Oncogene 35:4179-87.
339Chen NP et.al. (2016). Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion. Proc Natl Acad Sci U S A 113:990-5.
338Codo P et.al. (2016). Control of glioma cell migration and invasiveness by GDF-15. Oncotarget 7:7732-46.
337Flori M et.al. (2016). The hematopoietic oncoprotein FOXP1 promotes tumor cell survival in diffuse large B-cell lymphoma by repressing S1PR2 signaling. Blood 127:1438-48.
336Dey A et.al. (2016). YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells. Oncogene 35:4256-68.
335Beach JA et.al. (2016). Sphingosine kinase 1 is required for TGF-beta mediated fibroblastto Oncotarget 7:4167-82.
334Roth SA et.al. (2016). Next generation sequencing of microRNAs from isogenic neuroblastoma cell lines isolated before and after treatment. Cancer Lett 372:128-36.
333Ochs K et.al. (2016). Tryptophan-2,3-dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor-4. J Neurochem 136:1142-1154.
332Bedekovics T et.al. (2016). UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma. Blood 127:1564-74.
331DAsti E et.al. (2016). Tissue Factor Regulation by miR-520g in Primitive Neuronal Brain Tumor Cells: A Possible Link between Oncomirs and the Vascular Tumor Microenvironment. Am J Pathol 186:446-59.
330Shen B et.al. (2016). Upregulated SMYD3 promotes bladder cancer progression by targeting BCLAF1 and activating autophagy. Tumour Biol 37:7371-81.
329Henssen A et.al. (2016). Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition. Clin Cancer Res 22:2470-81.
328Fest S et.al. (2016). Targeting of heme oxygenase-1 as a novel immune regulator of neuroblastoma. Int J Cancer 138:2030-42.
327Xuan F et.al. (2016). Homeobox C9 suppresses Beclin1-mediated autophagy in glioblastoma by directly inhibiting the transcription of death-associated protein kinase 1. Neuro Oncol 18:819-29.
326Martins-Neves SR et.al. (2016). Chemotherapy induces stemness in osteosarcoma cells through activation of Wnt/beta-catenin signaling. Cancer Lett 370:286-95.
325Zhao X et.al. (2016). CTCF cooperates with noncoding RNA MYCNOS to promote neuroblastoma progression through facilitating MYCN expression. Oncogene 35:3565-76.
324Silginer M et.al. (2016). The aryl hydrocarbon receptor links integrin signaling to the TGF-beta pathway. Oncogene 35:3260-71.
323Masserot C et.al. (2016). WT1 expression is inversely correlated with MYCN amplification or expression and associated with poor survival in non-MYCN-amplified neuroblastoma. Mol Oncol 10:240-52.
322Jin Y et.al. (2016). Single nucleotide polymorphism rs11669203 in TGFBR3L is associated with the risk of neuroblastoma in a Chinese population. Tumour Biol 37:3739-47.
321Godin-Heymann N et.al. (2016). Tumour-suppression function of KLF12 through regulation of anoikis. Oncogene 35:3324-34.
320Guo ST et.al. (2016). INPP4B is an oncogenic regulator in human colon cancer. Oncogene 35:3049-61.
319Martins-Neves SR et.al. (2016). Osteosarcoma Stem Cells Have Active Wnt/beta-catenin and Overexpress SOX2 and KLF4. J Cell Physiol 231:876-86.
318Rad A et.al. (2016). Predicting the molecular role of MEIS1 in esophageal squamous cell carcinoma. Tumour Biol 37:1715-25.
317Rogers MA et.al. (2016). CITED4 gene silencing in colorectal cancer cells modulates adherens/tight junction gene expression and reduces cell proliferation. J Cancer Res Clin Oncol 142:225-37.
316Heim S et.al. (2016). Papillary Tumor of the Pineal Region: A Distinct Molecular Entity. Brain Pathol 26:199-205.
2015 (n=123)
315Dolman ME et.al. (2015). DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells. PLoS One 10:e0145744.
314Forgham H et.al. (2015). Stem Cell Markers in Neuroblastoma-An Emerging Role for LGR5. Front Cell Dev Biol 3:77.
313Ordonez-Moran P et.al. (2015). HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer. Cancer Cell 28:815-829.
312Giachino C et.al. (2015). A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes. Cancer Cell 28:730-742.
311Wickstrom M et.al. (2015). Wnt/beta-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance. Nat Commun 6:8904.
310Carter DR et.al. (2015). Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma. Sci Transl Med 7:312ra176.
309Xiao D et.al. (2015). Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2. Oncotarget 6:40655-66.
308Best MG et.al. (2015). RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics. Cancer Cell 28:666-676.
307Valentijn LJ et.al. (2015). TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors. Nat Genet 47:1411-4.
306Vieira GC et.al. (2015). LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/beta-catenin signalling in neuroblastoma. Oncotarget 6:40053-67.
305Trumpi K et.al. (2015). ABC-Transporter Expression Does Not Correlate with Response to Irinotecan in Patients with Metastatic Colorectal Cancer. J Cancer 6:1079-86.
304Hussain S et.al. (2015). UCHL1 is a biomarker of aggressive multiple myeloma required for disease progression. Oncotarget 6:40704-18.
303Bogen D et.al. (2015). Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma. Oncotarget 6:35247-62.
302Raman P et.al. (2015). FXYD5 is a Marker for Poor Prognosis and a Potential Driver for Metastasis in Ovarian Carcinomas. Cancer Inform 14:113-9.
301Sun Y et.al. (2015). WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma. Cancer Res 75:5143-54.
300Park SY et.al. (2015). Combinatorial TGF-beta attenuation with paclitaxel inhibits the epithelial-to-mesenchymal transition and breast cancer stem-like cells. Oncotarget 6:37526-43.
299Wielenga MCB et.al. (2015). ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy. Cell Rep 13:489-494.
298Bergenfelz C et.al. (2015). S100A9 expressed in ER(-)PgR(-) breast cancers induces inflammatory cytokines and is associated with an impaired overall survival. Br J Cancer 113:1234-43.
297Mohlin S et.al. (2015). PI3K-mTORC2 but not PI3K-mTORC1 regulates transcription of HIF2A/EPAS1 and vascularization in neuroblastoma. Cancer Res 75:4617-28.
296Baranski Z et.al. (2015). Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin. Oncotarget 6:36113-25.
295Shchors K et.al. (2015). Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit. Cancer Cell 28:456-471.
294Dassi E et.al. (2015). Translational compensation of genomic instability in neuroblastoma. Sci Rep 5:14364.
293Mehmeti M et.al. (2015). Expression of functional toll like receptor 4 in estrogen receptor/progesterone receptor-negative breast cancer. Breast Cancer Res 17:130.
292Fontebasso AM et.al. (2015). Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age. Oncotarget 6:31844-56.
291Khan FH et.al. (2015). RD3 loss dictates high-risk aggressive neuroblastoma and poor clinical outcomes. Oncotarget 6:36522-34.
290Liu Z et.al. (2015). Suboptimal cytoreduction in ovarian carcinoma is associated with molecular pathways characteristic of increased stromal activation. Gynecol Oncol 139:394-400.
289Li C et.al. (2015). Identification and characterization of ANO9 in stage II and III colorectal carcinoma. Oncotarget 6:29324-34.
288De Mariano M et.al. (2015). Identification of GALNT14 as a novel neuroblastoma predisposition gene. Oncotarget 6:26335-46.
287Bartolini A et.al. (2015). The Neuronal Pentraxin-2 Pathway Is an Unrecognized Target in Human Neuroblastoma, Which Also Offers Prognostic Value in Patients. Cancer Res 75:4265-71.
286Zheng Y et.al. (2015). FoxM1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion. BMC Med Genomics 8:49.
285Choe SC et.al. (2015). Autophagy capacity and sub-mitochondrial heterogeneity shape Bnip3-induced mitophagy regulation of apoptosis. Cell Commun Signal 13:37.
284Lee EJ et.al. (2015). Identification of Global DNA Methylation Signatures in Glioblastoma-Derived Cancer Stem Cells. J Genet Genomics 42:355-71.
283Ramani P et.al. (2015). High proliferation index, as determined by immunohistochemical expression of Aurora kinase B and geminin, indicates poor prognosis in neuroblastomas. Virchows Arch 467:319-27.
282Stigliani S et.al. (2015). Expression of FOXP3, CD14, and ARG1 in Neuroblastoma Tumor Tissue from High-Risk Patients Predicts Event-Free and Overall Survival. Biomed Res Int 2015:347867.
281Khan FH et.al. (2015). Acquired genetic alterations in tumor cells dictate the development of high-risk neuroblastoma and clinical outcomes. BMC Cancer 15:514.
280Ochodnicka-Mackovicova K et.al. (2015). NF-kappaB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity. Blood 126:1324-35.
279Khan FH et.al. (2015). Reorganization of metastamiRs in the evolution of metastatic aggressive neuroblastoma cells. BMC Genomics 16:501.
278Eleveld TF et.al. (2015). Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations. Nat Genet 47:864-71.
277Sahay D et.al. (2015). The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer. Oncotarget 6:20604-20.
276Eling N et.al. (2015). Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells. Oncoscience 2:517-32.
275Yco LP et.al. (2015). Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target. BMC Cancer 15:477.
274Larsson K et.al. (2015). COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset. Proc Natl Acad Sci U S A 112:8070-5.
273Stermann A et.al. (2015). Targeting of MYCN by means of DNA vaccination is effective against neuroblastoma in mice. Cancer Immunol Immunother 64:1215-27.
272Cimmino F et.al. (2015). Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells. Sci Rep 5:11158.
271Tummers B et.al. (2015). The interferon-related developmental regulator 1 is used by human papillomavirus to suppress NFkappaB activation. Nat Commun 6:6537.
270Mussai F et.al. (2015). Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity. Cancer Res 75:3043-53.
269Mandriota SJ et.al. (2015). Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism. Oncotarget 6:18558-76.
268Xiang X et.al. (2015). miRNA-584-5p exerts tumor suppressive functions in human neuroblastoma through repressing transcription of matrix metalloproteinase 14. Biochim Biophys Acta 1852:1743-54.
267Boer JM et.al. (2015). BCR-ABL1-like cases in pediatric acute lymphoblastic leukemia: a comparison between DCOG/Erasmus MC and COG/St. Jude signatures. Haematologica 100:e354-7.
266Tian T et.al. (2015). TAZ promotes temozolomide resistance by upregulating MCL-1 in human glioma cells. Biochem Biophys Res Commun 463:638-43.
265Schwermer M et.al. (2015). Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors. Oncotarget 6:15425-35.
264Bunt J et.al. (2015). PAX6 does not regulate Nfia and Nfib expression during neocortical development. Sci Rep 5:10668.
263Young SA et.al. (2015). Integrin alpha4 Enhances Metastasis and May Be Associated with Poor Prognosis in MYCN-low Neuroblastoma. PLoS One 10:e0120815.
262Challagundla KB et.al. (2015). Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy. J Natl Cancer Inst 107:.
261Liu CY et.al. (2015). Vimentin contributes to epithelial-mesenchymal transition cancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation. Oncotarget 6:15966-83.
260Pajtler KW et.al. (2015). Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups. Cancer Cell 27:728-43.
259Cheung BB et.al. (2015). Thymosin-beta4 is a determinant of drug sensitivity for Fenretinide and Vorinostat combination therapy in neuroblastoma. Mol Oncol 9:1484-500.
258Fatrai S et.al. (2015). Maintenance of Clonogenic KIT(+) Human Colon Tumor Cells Requires Secretion of Stem Cell Factor by Differentiated Tumor Cells. Gastroenterology 149:692-704.
257van de Wetering M et.al. (2015). Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell 161:933-45.
256Kuo YT et.al. (2015). JARID1B Expression Plays a Critical Role in Chemoresistance and Stem Cell-Like Phenotype of Neuroblastoma Cells. PLoS One 10:e0125343.
255Wang M et.al. (2015). Transcriptional co-activator TAZ sustains proliferation and tumorigenicity of neuroblastoma by targeting CTGF and PDGF-beta. Oncotarget 6:9517-30.
254Delic S et.al. (2015). Systematic investigation of CMTM family genes suggests relevance to glioblastoma pathogenesis and CMTM1 and CMTM3 as priority targets. Genes Chromosomes Cancer 54:433-43.
253Cheon DJ et.al. (2015). ADAM12 is a prognostic factor associated with an aggressive molecular subtype of high-grade serous ovarian carcinoma. Carcinogenesis 36:739-47.
252Yang J et.al. (2015). The role of histone demethylase KDM4B in Myc signaling in neuroblastoma. J Natl Cancer Inst 107:djv080.
251Cheng P et.al. (2015). Kinome-wide shRNA screen identifies the receptor tyrosine kinase AXL as a key regulator for mesenchymal glioblastoma stem-like cells. Stem Cell Reports 4:899-913.
250Salm F et.al. (2015). The Phosphoinositide 3-Kinase p110alpha Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma. PLoS One 10:e0123958.
249Hamidian A et.al. (2015). Differential regulation of HIF-1alpha and HIF-2alpha in neuroblastoma: Estrogen-related receptor alpha (ERRalpha) regulates HIF2A transcription and correlates to poor outcome. Biochem Biophys Res Commun 461:560-7.
248Vaillant C et.al. (2015). Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma. PLoS One 10:e0124870.
247Li D et.al. (2015). Intelectin 1 suppresses the growth, invasion and metastasis of neuroblastoma cells through up-regulation of N-myc downstream regulated gene 2. Mol Cancer 14:47.
246Bui TT et.al. (2015). gamma-Glutamyl transferase 7 is a novel regulator of glioblastoma growth. BMC Cancer 15:225.
245Chakrabarti G et.al. (2015). Expanding antitumor therapeutic windows by targeting cancer-specific nicotinamide adenine dinucleotide phosphate-biogenesis pathways. Clin Pharmacol 7:57-68.
244Sousa SF et.al. (2015). Defects of the Carney complex gene (PRKAR1A) in odontogenic tumors. Endocr Relat Cancer 22:399-408.
243Perez-Gomez E et.al. (2015). Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer. 107:djv077.
242Ecker J et.al. (2015). Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma. Acta Neuropathol Commun 3:22.
241Frei K et.al. (2015). Transforming growth factor-beta pathway activity in glioblastoma. Oncotarget 6:5963-77.
240Schmid CA et.al. (2015). DUSP4 deficiency caused by promoter hypermethylation drives JNK signaling and tumor cell survival in diffuse large B cell lymphoma. J Exp Med 212:775-92.
239Evans L et.al. (2015). SKP2 is a direct transcriptional target of MYCN and a potential therapeutic target in neuroblastoma. Cancer Lett 363:37-45.
238Sanden E et.al. (2015). Aberrant immunostaining pattern of the CD24 glycoprotein in clinical samples and experimental models of pediatric medulloblastomas. J Neurooncol 123:1-13.
237Pahl JH et.al. (2015). Expression of the immune regulation antigen CD70 in osteosarcoma. Cancer Cell Int 15:31.
236Wylie LA et.al. (2015). Ascl1 phospho-status regulates neuronal differentiation in a Xenopus developmental model of neuroblastoma. Dis Model Mech 8:429-41.
235Vellinga TT et.al. (2015). SIRT1/PGC1alpha-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer. Clin Cancer Res 21:2870-9.
234Yanez Y et.al. (2015). Two independent epigenetic biomarkers predict survival in neuroblastoma. Clin Epigenetics 7:16.
233Zhao Z et.al. (2015). microRNA-449a functions as a tumor suppressor in neuroblastoma through inducing cell differentiation and cell cycle arrest. RNA Biol 12:538-54.
232Yang R et.al. (2015). HDAC9 promotes glioblastoma growth via TAZ-mediated EGFR pathway activation. Oncotarget 6:7644-56.
231Baranski Z et.al. (2015). Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma. J Pathol 236:348-59.
230Bell JL et.al. (2015). IGF2BP1 harbors prognostic significance by gene gain and diverse expression in neuroblastoma. J Clin Oncol 33:1285-93.
229Zhang Y et.al. (2015). miR-182 promotes cell growth and invasion by targeting forkhead box F2 transcription factor in colorectal cancer. Oncol Rep 33:2592-8.
228Mussai F et.al. (2015). Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target. Blood 125:2386-96.
227Song R et.al. (2015). Connecting rules from paired miRNA and mRNA expression data sets of HCV patients to detect both inverse and positive regulatory relationships. BMC Genomics 16 Suppl 2:S11.
226Rettig I et.al. (2015). Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation. Cell Death Dis 6:e1657.
225Wegert J et.al. (2015). Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors. Cancer Cell 27:298-311.
224Richter M et.al. (2015). WIP1 phosphatase as a potential therapeutic target in neuroblastoma. PLoS One 10:e0115635.
223von Stedingk K et.al. (2015). Individual patient risk stratification of high-risk neuroblastomas using a two-gene score suited for clinical use. Int J Cancer 137:868-77.
222Ouyang Q et.al. (2015). Neurotensin promotes the progression of malignant glioma through NTSR1 and impacts the prognosis of glioma patients. Mol Cancer 14:21.
221Chen J et.al. (2015). The genetics of splicing in neuroblastoma. Cancer Discov 5:380-95.
220Santhana Kumar K et.al. (2015). The Ser/Thr kinase MAP4K4 drives c-Met-induced motility and invasiveness in a cell-based model of SHH medulloblastoma. Springerplus 4:19.
219Amoroso F et.al. (2015). The P2X7 receptor is a key modulator of the PI3K/GSK3beta/VEGF signaling network: evidence in experimental neuroblastoma. Oncogene 34:5240-51.
218Qu H et.al. (2015). miRNA-558 promotes tumorigenesis and aggressiveness of neuroblastoma cells through activating the transcription of heparanase. Hum Mol Genet 24:2539-51.
217Xiang X et.al. (2015). Hepatocyte nuclear factor 4 alpha promotes the invasion, metastasis and angiogenesis of neuroblastoma cells via targeting matrix metalloproteinase 14. Cancer Lett 359:187-97.
216Zhao S et.al. (2015). NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma. Oncogene 34:5069-79.
215Wang F et.al. (2015). A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma. Oncotarget 6:2709-24.
214Nasser MW et.al. (2015). RAGE mediates S100A7-induced breast cancer growth and metastasis by modulating the tumor microenvironment. Cancer Res 75:974-85.
213Newman EA et.al. (2015). Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma. Mol Cancer Res 13:470-82.
212Nakaguro M et.al. (2015). Nucleolar protein PES1 is a marker of neuroblastoma outcome and is associated with neuroblastoma differentiation. Cancer Sci 106:237-43.
211Hartomo TB et.al. (2015). Involvement of aldehyde dehydrogenase 1A2 in the regulation of cancer stem cell properties in neuroblastoma. Int J Oncol 46:1089-98.
210Ren X et.al. (2015). Quantitative nuclear proteomics identifies that miR-137-mediated EZH2 reduction regulates resveratrol-induced apoptosis of neuroblastoma cells. Mol Cell Proteomics 14:316-28.
209Park JH et.al. (2015). Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cells. Mol Oncol 9:617-27.
208Yang HW et.al. (2015). A small subunit processome protein promotes cancer by altering translation. Oncogene 34:4471-81.
207Ryland KE et.al. (2015). Polycomb-dependent repression of the potassium channel-encoding gene KCNA5 promotes cancer cell survival under conditions of stress. Oncogene 34:4591-600.
206Krause S et.al. (2015). Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphoblastic leukemia (ALL) in the central nervous system (CNS). Blood 125:820-30.
205Unland R et.al. (2015). Analysis of the antiproliferative effects of 3-deazaneoplanocin A in combination with standard anticancer agents in rhabdoid tumor cell lines. Anticancer Drugs 26:301-11.
204Cwiek P et.al. (2015). RNA interference screening identifies a novel role for PCTK1/CDK16 in medulloblastoma with c-Myc amplification. Oncotarget 6:116-29.
203Bartfeld S et.al. (2015). In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology 148:126-136.e6.
202Beckers A et.al. (2015). MYCN-targeting miRNAs are predominantly downregulated during MYCNdriven neuroblastoma tumor formation. Oncotarget 6:5204-16.
201Harter PN et.al. (2015). Paired box gene 8 (PAX8) expression is associated with sonic hedgehog (SHH)/wingless int (WNT) subtypes, desmoplastic histology and patient survival in human medulloblastomas. Neuropathol Appl Neurobiol 41:165-79.
200Nitta RT et.al. (2015). Casein kinase 2alpha regulates glioblastoma brain tumor-initiating cell growth through the beta-catenin pathway. Oncogene 34:3688-99.
199Zeiner PS et.al. (2015). MIF Receptor CD74 is Restricted to Microglia/Macrophages, Associated with a M1-Polarized Immune Milieu and Prolonged Patient Survival in Gliomas. Brain Pathol 25:491-504.
198Fernandez S et.al. (2015). miR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer. Oncogene 34:3240-50.
197Harvey H et.al. (2015). Modulation of chemotherapeutic drug resistance in neuroblastoma SK-N-AS cells by the neural apoptosis inhibitory protein and miR-520f. Int J Cancer 136:1579-88.
196Ott M et.al. (2015). Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway. Glia 63:78-90.
195Kobayashi T et.al. (2015). Deubiquitinating activity of CYLD is impaired by SUMOylation in neuroblastoma cells. Oncogene 34:2251-60.
194Shimozato O et.al. (2015). Receptor-type protein tyrosine phosphatase kappa directly dephosphorylates CD133 and regulates downstream AKT activation. Oncogene 34:1949-60.
193Buss MC et.al. (2015). The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants. Oncogene 34:1126-40.
2014 (n=62)
192Pandey GK et.al. (2014). The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation. Cancer Cell 26:722-37.
191Simmini S et.al. (2014). Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2. Nat Commun 5:5728.
190Saini RK et.al. (2014). Proteomics of dedifferentiation of SK-N-BE2 neuroblastoma cells. Biochem Biophys Res Commun 454:202-9.
189Pajtler KW et.al. (2014). Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells. Oncotarget 5:11180-92.
188Chavali PL et.al. (2014). TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival. Cell Death Dis 5:e1502.
187Bandino A et.al. (2014). Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients. Cell Oncol (Dordr) 37:387-98.
186Lee S et.al. (2014). Robust selection of cancer survival signatures from high-throughput genomic data using two-fold subsampling. PLoS One 9:e108818.
185Zhang Z et.al. (2014). N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation. Oncotarget 5:7625-34.
184van Keimpema M et.al. (2014). FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-kappaB to promote survival of human B cells. Blood 124:3431-40.
183Emmink BL et.al. (2014). GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer. Cancer Res 74:6717-30.
182Jasinski-Bergner S et.al. (2014). Identification of 14-3-3beta gene as a novel miR-152 target using a proteome-based approach. J Biol Chem 289:31121-35.
181Ke XX et.al. (2014). Inhibition of H3K9 methyltransferase G9a repressed cell proliferation and induced autophagy in neuroblastoma cells. PLoS One 9:e106962.
180Sero V et.al. (2014). Targeting polo-like kinase 1 by NMS-P937 in osteosarcoma cell lines inhibits tumor cell growth and partially overcomes drug resistance. Invest New Drugs 32:1167-80.
179DAsti E et.al. (2014). Coagulation and angiogenic gene expression profiles are defined by molecular subgroups of medulloblastoma: evidence for growth factor-thrombin cross-talk. J Thromb Haemost 12:1838-49.
178Izumi H et.al. (2014). Trim32 facilitates degradation of MYCN on spindle poles and induces asymmetric cell division in human neuroblastoma cells. Cancer Res 74:5620-30.
177Basak O et.al. (2014). Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele. EMBO J 33:2057-68.
176Cangelosi D et.al. (2014). Use of Attribute Driven Incremental Discretization and Logic Learning Machine to build a prognostic classifier for neuroblastoma patients. BMC Bioinformatics 15 Suppl 5:S4.
175Rack PG et.al. (2014). Arhgap36-dependent activation of Gli transcription factors. Proc Natl Acad Sci U S A 111:11061-6.
174Rutten MJ et.al. (2014). HLA-G expression is an independent predictor for improved survival in high grade ovarian carcinomas. J Immunol Res 2014:274584.
173Weichhaus M et.al. (2014). Osteoprotegerin expression in triple-negative breast cancer cells promotes metastasis. Cancer Med 3:1112-25.
172Forget A et.al. (2014). Shh signaling protects Atoh1 from degradation mediated by the E3 ubiquitin ligase Huwe1 in neural precursors. Dev Cell 29:649-61.
171Shahbazi J et.al. (2014). Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1. Oncotarget 5:4257-68.
170Tummers B et.al. (2014). CD40-mediated amplification of local immunity by epithelial cells is impaired by HPV. J Invest Dermatol 134:2918-2927.
169Hiddingh L et.al. (2014). Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis. Sci Rep 4:5260.
168De Antonellis P et.al. (2014). Early targets of miR-34a in neuroblastoma. Mol Cell Proteomics 13:2114-31.
167Liu PY et.al. (2014). Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression. J Natl Cancer Inst 106:.
166Jeibmann A et.al. (2014). Identification of genes involved in the biology of atypical teratoid/rhabdoid tumours using Drosophila melanogaster. Nat Commun 5:4005.
165Quandt D et.al. (2014). Synergistic effects of IL-4 and TNFalpha on the induction of B7-H1 in renal cell carcinoma cells inhibiting allogeneic T cell proliferation. J Transl Med 12:151.
164Wille C et.al. (2014). Protein Kinase D family kinases: roads start to segregate. Bioarchitecture 4:111-5.
163Hovestadt V et.al. (2014). Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature 510:537-41.
162Zhu Z et.al. (2014). Targeting self-renewal in high-grade brain tumors leads to loss of brain tumor stem cells and prolonged survival. Cell Stem Cell 15:185-98.
161Tomiyama A et.al. (2014). Flotillin-1 regulates oncogenic signaling in neuroblastoma cells by regulating ALK membrane association. Cancer Res 74:3790-801.
160David M et.al. (2014). Identification of heparin-binding EGF-like growth factor (HB-EGF) as a biomarker for lysophosphatidic acid receptor type 1 (LPA1) activation in human breast and prostate cancers. PLoS One 9:e97771.
159Venkataraman S et.al. (2014). Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget 5:2355-71.
158Fiaschetti G et.al. (2014). NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma. Acta Neuropathol Commun 2:39.
157Litzenburger UM et.al. (2014). Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR. Oncotarget 5:1038-51.
156Kool M et.al. (2014). Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer Cell 25:393-405.
155Kerami Z et.al. (2014). Effect of interleukin-17 on gene expression profile of fibroblasts from Crohns disease patients. J Crohns Colitis 8:1208-16.
154van Buul JD et.al. (2014). Rho GAPs and GEFs: controling switches in endothelial cell adhesion. Cell Adh Migr 8:108-24.
153Koso H et.al. (2014). Identification of FoxR2 as an oncogene in medulloblastoma. Cancer Res 74:2351-61.
152Yamaguchi Y et.al. (2014). Novel 1p tumour suppressor Dnmt1-associated protein 1 regulates MYCN/ataxia telangiectasia mutated/p53 pathway. Eur J Cancer 50:1555-65.
151Laetsch TW et.al. (2014). Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma. Cell Death Dis 5:e1072.
150Murakami-Tonami Y et.al. (2014). Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells. Cell Cycle 13:1115-31.
149Xu B et.al. (2014). Regulation of endometrial receptivity by the highly expressed HOXA9, HOXA11 and HOXD10 HOX-class homeobox genes. Hum Reprod 29:781-90.
148Bageritz J et.al. (2014). Stem cell characteristics in glioblastoma are maintained by the ecto-nucleotidase E-NPP1. Cell Death Differ 21:929-40.
147Hiddingh L et.al. (2014). EFEMP1 induces gamma-secretase/Notch-mediated temozolomide resistance in glioblastoma. Oncotarget 5:363-74.
146van Vuurden DG et.al. (2014). Pre-B-cell leukemia homeobox interacting protein 1 is overexpressed in astrocytoma and promotes tumor cell growth and migration. Neuro Oncol 16:946-59.
145Chen ZX et.al. (2014). RNA helicase A is a downstream mediator of KIF1Bbeta tumor-suppressor function in neuroblastoma. Cancer Discov 4:434-51.
144Kerl K et.al. (2014). Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1. Int J Cancer 135:989-95.
143Fabian J et.al. (2014). GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3. Cancer Res 74:2604-16.
142Wolter JK et.al. (2014). Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma. Oncotarget 5:161-72.
141Wirsching HG et.al. (2014). Thymosin beta 4 gene silencing decreases stemness and invasiveness in glioblastoma. Brain 137:433-48.
140Fiaschetti G et.al. (2014). Epigenetic silencing of miRNA-9 is associated with HES1 oncogenic activity and poor prognosis of medulloblastoma. Br J Cancer 110:636-47.
139Fryer LG et.al. (2014). The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis. J Biol Chem 289:4244-61.
138Wille C et.al. (2014). Protein kinase D2 induces invasion of pancreatic cancer cells by regulating matrix metalloproteinases. Mol Biol Cell 25:324-36.
137Barbieri E et.al. (2014). Histone chaperone CHAF1A inhibits differentiation and promotes aggressive neuroblastoma. Cancer Res 74:765-74.
136Bate-Eya LT et.al. (2014). Newly-derived neuroblastoma cell lines propagated in serum-free media recapitulate the genotype and phenotype of primary neuroblastoma tumours. Eur J Cancer 50:628-37.
135Erdreich-Epstein A et.al. (2014). PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas. Clin Cancer Res 20:827-36.
134Ciarapica R et.al. (2014). The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx). Oncogene 33:4173-84.
133Sengupta S et.al. (2014). alpha5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth. Acta Neuropathol 127:593-603.
132Lange I et.al. (2014). Novel interaction of ornithine decarboxylase with sepiapterin reductase regulates neuroblastoma cell proliferation. J Mol Biol 426:332-46.
131Milla LA et.al. (2014). Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression. Int J Cancer 134:21-31.
2013 (n=56)
130Ecker J et.al. (2013). Targeting of histone deacetylases in brain tumors. CNS Oncol 2:359-76.
129Barbieri E et.al. (2013). A p53 drug response signature identifies prognostic genes in high-risk neuroblastoma. PLoS One 8:e79843.
128Ding J et.al. (2013). The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation. Cell Metab 18:896-907.
127Li D et.al. (2013). FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma. Oncotarget 4:2021-44.
126Pajtler KW et.al. (2013). The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma. Acta Neuropathol Commun 1:19.
125Whittier KL et.al. (2013). G-protein coupled receptor expression patterns delineate medulloblastoma subgroups. Acta Neuropathol Commun 1:66.
124Bergiers I et.al. (2013). The homeodomain transcription factor Hoxa2 interacts with and promotes the proteasomal degradation of the E3 ubiquitin protein ligase RCHY1. PLoS One 8:e80387.
123Henssen A et.al. (2013). BET bromodomain protein inhibition is a therapeutic option for medulloblastoma. Oncotarget 4:2080-95.
122Ingram WJ et.al. (2013). ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma. Exp Hematol Oncol 2:26.
121Totaro F et.al. (2013). Impact of interleukin-6 -174 G>C gene promoter polymorphism on neuroblastoma. PLoS One 8:e76810.
120Remke M et.al. (2013). TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma. Acta Neuropathol 126:917-29.
119Jager N et.al. (2013). Hypermutation of the inactive X chromosome is a frequent event in cancer. Cell 155:567-81.
118Fan YH et.al. (2013). USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis. Cell Death Dis 4:e867.
117Tavanti E et.al. (2013). Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma. Br J Cancer 109:2607-18.
116Stange DE et.al. (2013). Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell 155:357-68.
115Djos A et.al. (2013). Aneuploidy in neuroblastoma tumors is not associated with inactivating point mutations in the STAG2 gene. BMC Med Genet 14:102.
114Pascutti MF et.al. (2013). IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells. Blood 122:3010-9.
113Tan F et.al. (2013). Dihydropyrimidinase-like protein 3 expression is negatively regulated by MYCN and associated with clinical outcome in neuroblastoma. Cancer Sci 104:1586-92.
112Zeilstra J et.al. (2013). CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status. PLoS One 8:e72849.
111Snoeren N et.al. (2013). Maspin is a marker for early recurrence in primary stage III and IV colorectal cancer. Br J Cancer 109:1636-47.
110Tannous BA et.al. (2013). Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs. J Natl Cancer Inst 105:1322-31.
109Spina R et.al. (2013). Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells. Oncotarget 4:1280-92.
108Shi K et.al. (2013). Protease-activated receptor-2 induces migration of pancreatic cancer cells in an extracellular ATP-dependent manner. J Thromb Haemost 11:1892-902.
107Wilzen A et.al. (2013). ERBB3 is a marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile in neuroblastic tumours. Mol Cancer 12:70.
106Feng W et.al. (2013). The chromatin remodeler CHD7 regulates adult neurogenesis via activation of SoxC transcription factors. Cell Stem Cell 13:62-72.
105Jones DT et.al. (2013). Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nat Genet 45:927-32.
104Cangelosi D et.al. (2013). Logic Learning Machine creates explicit and stable rules stratifying neuroblastoma patients. BMC Bioinformatics 14 Suppl 7:S12.
103Oehme I et.al. (2013). Histone deacetylase 10 promotes autophagy-mediated cell survival. Proc Natl Acad Sci U S A 110:E2592-601.
102Abba M et.al. (2013). Unraveling the role of FOXQ1 in colorectal cancer metastasis. Mol Cancer Res 11:1017-28.
101Kaaij LT et.al. (2013). DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus. Genome Biol 14:R50.
100Leprivier G et.al. (2013). The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell 153:1064-79.
99Tomaselli S et.al. (2013). ADAR2 editing activity in newly diagnosed versus relapsed pediatric high-grade astrocytomas. BMC Cancer 13:255.
98Remke M et.al. (2013). Somatostatin receptor subtype 2 (sst(2)) is a potential prognostic marker and a therapeutic target in medulloblastoma. Childs Nerv Syst 29:1253-62.
97Gramatzki D et.al. (2013). Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway. PLoS One 8:e63527.
96van Nes J et.al. (2013). A NOTCH3 transcriptional module induces cell motility in neuroblastoma. Clin Cancer Res 19:3485-94.
95Veringa SJ et.al. (2013). In vitro drug response and efflux transporters associated with drug resistance in pediatric high grade glioma and diffuse intrinsic pontine glioma. PLoS One 8:e61512.
94Fransson S et.al. (2013). Aggressive neuroblastomas have high p110alpha but low p110delta and p55alpha/p50alpha protein levels compared to low stage neuroblastomas. J Mol Signal 8:4.
93Valdora F et.al. (2013). Epigenetic Silencing of DKK3 in medulloblastoma. Int J Mol Sci 14:7492-505.
92Lundberg G et.al. (2013). Intratumour diversity of chromosome copy numbers in neuroblastoma mediated by on-going chromosome loss from a polyploid state. PLoS One 8:e59268.
91Sahm F et.al. (2013). The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress. Cancer Res 73:3225-34.
90Creevey L et.al. (2013). MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1. Mol Cancer 12:23.
89Damon M et.al. (2013). Associations between muscle gene expression pattern and technological and sensory meat traits highlight new biomarkers for pork quality assessment. Meat Sci 95:744-54.
88Mohlin S et.al. (2013). HIF2A and IGF2 expression correlates in human neuroblastoma cells and normal immature sympathetic neuroblasts. Neoplasia 15:328-34.
87Carotenuto M et.al. (2013). Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction. Sci Rep 3:1351.
86Pettersen I et.al. (2013). Expression of TWEAK/Fn14 in neuroblastoma: implications in tumorigenesis. Int J Oncol 42:1239-48.
85Steller EJ et.al. (2013). PDGFRB promotes liver metastasis formation of mesenchymal-like colorectal tumor cells. Neoplasia 15:204-17.
84Yco LP et.al. (2013). PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma. Int J Oncol 42:1408-16.
83Koomoa DL et.al. (2013). DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma. Int J Oncol 42:1219-28.
82Pajtler KW et.al. (2013). Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma cells. Int J Cancer 133:908-19.
81Santo EE et.al. (2013). FOXO3a is a major target of inactivation by PI3K/AKT signaling in aggressive neuroblastoma. Cancer Res 73:2189-98.
80Caretti V et.al. (2013). WEE1 kinase inhibition enhances the radiation response of diffuse intrinsic pontine gliomas. Mol Cancer Ther 12:141-50.
79Zhu Y et.al. (2013). Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. J Biol Chem 288:1099-113.
78Wickstrom M et.al. (2013). Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo. Int J Cancer 132:1516-24.
77Sung PJ et.al. (2013). Identification and characterisation of STMN4 and ROBO2 gene involvement in neuroblastoma cell differentiation. Cancer Lett 328:168-75.
76Nakata S et.al. (2013). LGR5 is a marker of poor prognosis in glioblastoma and is required for survival of brain cancer stem-like cells. Brain Pathol 23:60-72.
75Das S et.al. (2013). Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs. Oncogene 32:2927-36.
2012 (n=39)
74Salih DA et.al. (2012). FoxO6 regulates memory consolidation and synaptic function. Genes Dev 26:2780-801.
73Le DT et.al. (2012). Differential gene expression in soybean leaf tissues at late developmental stages under drought stress revealed by genome-wide transcriptome analysis. PLoS One 7:e49522.
72Korshunov A et.al. (2012). LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR). Acta Neuropathol 124:875-81.
71Valentijn LJ et.al. (2012). Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification. Proc Natl Acad Sci U S A 109:19190-5.
70Sturm D et.al. (2012). Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 22:425-37.
69Schramm A et.al. (2012). Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome. Br J Cancer 107:1409-17.
68Molenaar JJ et.al. (2012). LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. Nat Genet 44:1199-206.
67von Bueren AO et.al. (2012). Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours. Br J Cancer 107:1399-408.
66Diskin SJ et.al. (2012). Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. Nat Genet 44:1126-30.
65Liu XY et.al. (2012). Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations. Acta Neuropathol 124:615-25.
64Jones DT et.al. (2012). Dissecting the genomic complexity underlying medulloblastoma. Nature 488:100-5.
63Grunewald TG et.al. (2012). The STEAP protein family: versatile oxidoreductases and targets for cancer immunotherapy with overlapping and distinct cellular functions. Biol Cell 104:641-57.
62Lamers F et.al. (2012). Identification of BIRC6 as a novel intervention target for neuroblastoma therapy. BMC Cancer 12:285.
61Wernicke CM et.al. (2012). MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival. Leuk Res 36:1185-92.
60Smits M et.al. (2012). EZH2-regulated DAB2IP is a medulloblastoma tumor suppressor and a positive marker for survival. Clin Cancer Res 18:4048-58.
59Geurts van Kessel A et.al. (2012). New insights and clinical advancements in cellular oncology. Cell Oncol (Dordr) 35:139-47.
58Munoz J et.al. (2012). The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent +4 cell markers. EMBO J 31:3079-91.
57Kunkele A et.al. (2012). Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas. Neuro Oncol 14:859-69.
56Lawlor ER et.al. (2012). Epigenetic changes in pediatric solid tumors: promising new targets. Clin Cancer Res 18:2768-79.
55Milde T et.al. (2012). Nestin expression identifies ependymoma patients with poor outcome. Brain Pathol 22:848-60.
54Lee MJ et.al. (2012). Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model. Proc Natl Acad Sci U S A 109:7859-64.
53Cornero A et.al. (2012). Design of a multi-signature ensemble classifier predicting neuroblastoma patients outcome. BMC Bioinformatics 13 Suppl 4:S13.
52Kemper K et.al. (2012). Mutations in the Ras-Raf Axis underlie the prognostic value of CD133 in colorectal cancer. Clin Cancer Res 18:3132-41.
51Lynch J et.al. (2012). MiRNA-335 suppresses neuroblastoma cell invasiveness by direct targeting of multiple genes from the non-canonical TGF-beta signalling pathway. Carcinogenesis 33:976-85.
50Molenaar JJ et.al. (2012). Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes. Nature 483:589-93.
49Lamers F et.al. (2012). Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth. Eur J Cancer 48:3093-103.
48Kool M et.al. (2012). Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol 123:473-84.
47Grammel D et.al. (2012). Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem. Acta Neuropathol 123:601-14.
46Meehan M et.al. (2012). Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase A oncogene. Mol Cancer 11:6.
45Rasmuson A et.al. (2012). Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma. PLoS One 7:e29331.
44Gawecka JE et.al. (2012). PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma. Int J Cancer 131:1556-68.
43Dittmann LM et.al. (2012). Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio Oncogene 31:3409-18.
42Hoogewijs D et.al. (2012). Androglobin: a chimeric globin in metazoans that is preferentially expressed in Mammalian testes. Mol Biol Evol 29:1105-14.
41Sulzmaier FJ et.al. (2012). PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D. Oncogene 31:3547-60.
40Lamers F et.al. (2012). Targeted BIRC5 silencing using YM155 causes cell death in neuroblastoma cells with low ABCB1 expression. Eur J Cancer 48:763-71.
39Wang C et.al. (2012). EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR. Cancer Res 72:315-24.
38Molenaar JJ et.al. (2012). Copy number defects of G1-cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis. Genes Chromosomes Cancer 51:10-9.
37Bunt J et.al. (2012). OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells. Int J Cancer 131:E21-32.
36Santo EE et.al. (2012). Oncogenic activation of FOXR1 by 11q23 intrachromosomal deletion-fusions in neuroblastoma. Oncogene 31:1571-81.
2011 (n=10)
35Thomas DM et.al. (2011). Workshop Report on the European Bone Sarcoma Networking Meeting: Integration of Clinical Trials with Tumor Biology. J Adolesc Young Adult Oncol 1:118-23.
34van Vuurden DG et.al. (2011). PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation. Oncotarget 2:984-96.
33de Sousa E Melo F et.al. (2011). Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. Cell Stem Cell 9:476-85.
32Bunt J et.al. (2011). Joint binding of OTX2 and MYC in promotor regions is associated with high gene expression in medulloblastoma. PLoS One 6:e26058.
31Lamers F et.al. (2011). Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe. Endocr Relat Cancer 18:657-68.
30Haug BH et.al. (2011). MYCN-regulated miRNA-92 inhibits secretion of the tumor suppressor DICKKOPF-3 (DKK3) in neuroblastoma. Carcinogenesis 32:1005-12.
29Murphy DM et.al. (2011). Dissection of the oncogenic MYCN transcriptional network reveals a large set of clinically relevant cell cycle genes as drivers of neuroblastoma tumorigenesis. Mol Carcinog 50:403-11.
28PosthumaDeBoer J et.al. (2011). WEE1 inhibition sensitizes osteosarcoma to radiotherapy. BMC Cancer 11:156.
27Liu Z et.al. (2011). CASZ1, a candidate tumor-suppressor gene, suppresses neuroblastoma tumor growth through reprogramming gene expression. Cell Death Differ 18:1174-83.
26Buckley PG et.al. (2011). Genome-wide DNA methylation analysis of neuroblastic tumors reveals clinically relevant epigenetic events and large-scale epigenomic alterations localized to telomeric regions. Int J Cancer 128:2296-305.
2010 (n=8)
25Bunt J et.al. (2010). Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines. Mol Cancer Res 8:1344-57.
24Mergui X et.al. (2010). p21Waf1 expression is regulated by nuclear intermediate filament vimentin in neuroblastoma. BMC Cancer 10:473.
23Holzel M et.al. (2010). NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome. Cell 142:218-29.
22Borsics T et.al. (2010). Subcellular distribution and expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in malignant glioma: Influence on cell survival and migration. Cancer Sci 101:1624-31.
21Verissimo CS et.al. (2010). Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells. Endocr Relat Cancer 17:399-414.
20Molenaar JJ et.al. (2010). Cyclin D1 is a direct transcriptional target of GATA3 in neuroblastoma tumor cells. Oncogene 29:2739-45.
19Geerts D et.al. (2010). The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification. Int J Cancer 126:2012-24.
18Revet I et.al. (2010). MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3. Cancer Lett 289:195-207.
2009 (n=7)
17Molenaar JJ et.al. (2009). Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells. Proc Natl Acad Sci U S A 106:12968-73.
16Cimmino F et.al. (2009). Galectin-1 is a major effector of TrkB-mediated neuroblastoma aggressiveness. Oncogene 28:2015-23.
15Huang S et.al. (2009). ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. Cancer Cell 15:328-40.
14van Hooff SR et.al. (2009). The construction of genome-based transcriptional units. OMICS 13:105-14.
13Missiaglia E et.al. (2009). Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: an approach to identify candidate genes involved in tumor development. Genes Chromosomes Cancer 48:455-67.
12Schulte JH et.al. (2009). Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. Cancer Res 69:2065-71.
11Schulte JH et.al. (2009). The low-affinity neurotrophin receptor, p75, is upregulated in ganglioneuroblastoma/ganglioneuroma and reduces tumorigenicity of neuroblastoma cells in vivo. Int J Cancer 124:2488-94.
2008 (n=5)
10Kool M et.al. (2008). Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One 3:e3088.
9Molenaar JJ et.al. (2008). Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma. Cancer Res 68:2599-609.
8Revet I et.al. (2008). The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma. Exp Cell Res 314:707-19.
7Merks JH et.al. (2008). Prevalence and patterns of morphological abnormalities in patients with childhood cancer. JAMA 299:61-9.
6Koppen A et.al. (2008). Dickkopf-3 expression is a marker for neuroblastic tumor maturation and is down-regulated by MYCN. Int J Cancer 122:1455-64.
2007 (n=4)
5Geerts D et.al. (2007). Expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in neuroblastoma: correlation with clinical features, cellular localization, and cerulenin-mediated apoptosis regulation. Clin Cancer Res 13:6312-9.
4Koppen A et.al. (2007). Direct regulation of the minichromosome maintenance complex by MYCN in neuroblastoma. Eur J Cancer 43:2413-22.
3Koppen A et.al. (2007). Dickkopf-1 is down-regulated by MYCN and inhibits neuroblastoma cell proliferation. Cancer Lett 256:218-28.
2Mainguy G et.al. (2007). Extensive polycistronism and antisense transcription in the mammalian Hox clusters. PLoS One 2:e356.
2006 (n=1)
1Valentijn LJ et.al. (2006). Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV. Genomics 87:483-9.
AMC: OncogenomicsGo to: MainOpen access