pathology_of_human_tumor:at original diagnosis: high grade neoplastic population of cells. these have small, moderately pleomorphic round to oval and often angulated dark blue nuclei with small blue nucleoli. the cells have a small amount of pink cytoplasm. there is a background of pink neuropil, and in areas the nuclei palisade in a striped pattern along the pink neuropil. there are individual apoptotic cells as well as field necrosis, and mitoses are plentiful. the neoplastic cells infiltrate adjacent brain tissue. at recurrence: predominant features of a glioblastoma multiforme with pseudo-palisading necrosis, vascular proliferation and immunoreactivity for gfap supporting glial astrocytic differentiation.