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Alternative names:
age: 2.8
gender: male
location: cerebellum
diagnosis: medulloblastoma, classic
pre-treatment: none
source: surgery
stage: m0
efs_(months): >60
os_(months): >60
Explore Histology

pathology_of_human_tumor: h&e stained sections show a heterogeneous "small round blue cell" neoplasm. in many areas the cells have dense, hyperchromatic, irregularly shaped nuclei with scant amounts of light pink cytoplasm. there is moderate mitotic activity. focally, the neoplasm is growing in sheets and small nests. much of the tumor contains a rich neuropil background and ganglion cell differentiation is easily identified occasionally binucleated ganglion cells are noted. only very focal frank nodule formation is apparent. immunoperoxidase staining for ini-1 shows diffuse nuclear expression. some areas of the tumor have marked neuronal differentiation with easily identified ganglion cells. neuropil is moderately abundant.
mouse_strain: nod scid gamma (nsg)
site_of_transplantation: cerebellum
protocol: olson lab pdox protocol
days_to_p0_p1_p2: 64 49 42
pi: james m. olson
contact: http://www.btrl.org/product/med-211fh/

entity: medulloblastoma
subgroup: grp3
curated_lesions: myc amplification, gfi1b activation (structural rearrangement + overexpression)

View karyo in GenomeBrowser

plot: med-211fh_p2
AMC: OncogenomicsGo to: Main | Pediatric PDX (Olson) portalOpen access