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med-1911fh
Alternative names:
1.patient
age: 3.5
gender: female
location: cerebellum
diagnosis: medulloblastoma, anaplastic large cell
pre-treatment: none
source: surgery
stage: m3
treatment_follow_up:
efs_(months): >60
os_(months): >60
consent:
Explore Histology

pathology_of_human_tumor: the malignant hypercellular tumor is comprised of sheets of small to intermediate sized cells that are regionally heterogeneous, partly due to cellular disassociation and geographic necrosis that includes prominent apoptosis. in many areas the neoplastic cells are small, with round to angular nuclei that contain stippled chromatin, indiscrete nucleoli and little cytoplasm in a few foci intervening neuropil is appreciated. however, in multiple regions, including perivascular accentuation, the tumor cells are enlarged and have ovoid to angular nuclei with cleared chromatin and prominent nucleoli. some cells in these foci have eccentric nuclei and a moderate amount of eosinophilic cytoplasm. nuclear molding and cellular "cannibalism" is apparent in these regions as well as increased mitotic activity. immunoperoxidase staining shows retained expression of ini-1.
2.model
mouse_strain: nod scid gamma (nsg)
site_of_transplantation: cerebellum
protocol: olson lab pdox protocol
days_to_p0_p1_p2: 128 55 78
pi: james m. olson
contact: http://www.btrl.org/product/med-1911fh/

3.molecular
entity: medulloblastoma
subgroup: grp3
curated_lesions: myc (amplification), kbtbd4 (missense mutation, probably rare snp, not in hotspot!)

View karyo in GenomeBrowser

plot: med-1911fh_p2
AMC: OncogenomicsGo to: Main | Pediatric PDX (Olson) portalOpen access