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age: 11.3
gender: male
location: cortex, left temporal lobe
diagnosis: glioblastoma multiforme
pre-treatment: radiation and chemotherapy
source: recurrent, autopsy
stage: metastatic at time of autopsy
efs_(months): 4.3 from diagnosis
os_(months): 5.5 from diagnosis
Explore Histology

pathology_of_human_tumor: the post-treatment autopsy sample showed a pleomorphic population of malignant cells, but the small cell component was much more prominent in the limited sample obtained. the tumor displayed predominantly leptomeningeal involvement with extension along virchow-robin spaces and only focal direct infiltration of normal brain. immunohistochemical synaptophysin stains again showed weak cytoplasmic immunoreactivity in some cells, with interpretation again varying as to whether this should be called "positive" or "negative". gfap staining was less intense than the original, but many of the giant malignant cells had variable gfap positivity.
mouse_strain: nod scid gamma (nsg)
site_of_transplantation: cortex
protocol: olson lab pdox protocol
days_to_p0_p1_p2: 128 86 79
pi: james m. olson
contact: http://www.btrl.org/product/gbm-611fh/

entity: high-grade glioma
subgroup: pedrtk1
curated_lesions: hypermutator, msh2 (stopgain + splicing mutation), atrx (missense mutation), tp53 (missense mutation)

View karyo in GenomeBrowser

plot: gbm-611fh_p1
AMC: OncogenomicsGo to: Main | Pediatric PDX (Olson) portalOpen access