age: 11.3 gender: male location: cortex, left temporal lobe diagnosis: glioblastoma multiforme pre-treatment: radiation and chemotherapy source: recurrent, autopsy stage: metastatic at time of autopsy treatment_follow_up: efs_(months): 4.3 from diagnosis os_(months): 5.5 from diagnosis consent:
pathology_of_human_tumor:the post-treatment autopsy sample showed a pleomorphic population of malignant cells, but the small cell component was much more prominent in the limited sample obtained. the tumor displayed predominantly leptomeningeal involvement with extension along virchow-robin spaces and only focal direct infiltration of normal brain. immunohistochemical synaptophysin stains again showed weak cytoplasmic immunoreactivity in some cells, with interpretation again varying as to whether this should be called "positive" or "negative". gfap staining was less intense than the original, but many of the giant malignant cells had variable gfap positivity.